5
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35423 |
7-oxo Staurosporine
|
||
7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits gr... | |||
T69476 |
5'-Hydroxy-staurosporine
|
||
5'-Hydroxy-staurosporine is an AMPK inhibitor with selective toxicity toward human colon tumor cells. | |||
T70683 |
NA 382
|
||
NA 382 is a staurosporine derivative that inhibits multidrug resistance. | |||
T69812 |
AFN941
|
||
AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor. | |||
T24027 |
EM20-25
EM2025,EM20 25 |
||
EM20-25 is a novel BCL-2 inhibitor. It also neutralizes the antiapoptotic activity of overexpressed BCL-2 toward staurosporine. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6680 |
Staurosporine
Antibiotic AM-2282,星形孢菌素,AM-2282,CGP 41251,星孢菌素 |
Apoptosis; PKA; Antibacterial; Antibiotic; Src; PKC; Antifungal | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Staurosporine (AM-2282) 是一种蛋白激酶抑制剂,对 PKC、PKA、c-Fgr、Phosphorylase kinase 和 TAOK2 均有抑制活性 (IC50=6/15/2/3/3000 nM),具有 ATP 竞争性和非选择性。Staurosporine 也可以诱导凋亡。 | |||
T6S1740 |
Nardosinone
苷松新酮,甘松新酮 |
Others | Others |
Nardosinone 是一个 dbcAMP 和 staurosporine 的神经生成作用增强剂,分离自Nardostachys chinensis 中。Nardosinone 可能成为一种有用的药理学工具,不仅可用于研究神经生长因子 (NGF) 的作用机理,而且可用于研究神经毒性物质的作用机理。 | |||
T2787 |
Picroside I
6'-Cinnamoylcatalpol,胡黄连苦苷I |
MMP; STAT | JAK/STAT signaling; Proteases/Proteasome; Stem Cells |
Picroside I (6'-Cinnamoylcatalpol) 是胡黄连的一种天然产物,是有肝脏保护作用的代谢成分,可用于哮喘研究,有减轻炎症作用,还下调 pSTAT6 和 GATA3 表达。 | |||
TN2257 |
Tanshinone IIB
丹参酮ⅡB |
BCL; Caspase; P-gp | Apoptosis; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome |
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the elevated Bax protein and decreased bc | |||
T15636 |
K-252a
Antibiotic K 252a,Antibiotic SF 2370,SF2370 |
Others | Others |
K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively). | |||
T15638 |
K-252c
|
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 μM). K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase. K-252c causes apoptosis in human chronic myelogenous leukemia cancer cells. |