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Cat. No. | Product Name | Target | Signaling Pathways |
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T24557 |
NSC756093
NSC-756093,NSC 756093 |
Others | Others |
NSC756093 可能抑制 GBP1:PIM1 相互作用。 NSC756093 可用于卵巢癌研究。 | |||
T17842 |
DOTA-NHS-ester
|
Others | Others |
DOTA-NHS-ester 是 affibody 分子的接头,应用于小动物 PET、SPECT 和 CT。 它可用于标记放射治疗剂或成像探针以检测肿瘤。 | |||
T13224 |
Tubulin inhibitor 6
iHAP1 |
Microtubule Associated | Cytoskeletal Signaling |
Tubulin inhibitor 6 (iHAP1) 是一种微管蛋白抑制剂,抑制微管蛋白聚合,IC50为 0.87 μM。它抑制多种癌细胞系,抑制 K562 细胞生长,IC50为 840 nM。 | |||
T6909 |
NSC348884
N1,N1,N2,N2-四[(6-甲基-1H-苯并咪唑-2-基)甲基]-1,2-乙二胺 |
Apoptosis; p53 | Apoptosis |
NSC348884 是一种核磷蛋白抑制剂,可破坏寡聚体形成并诱导细胞凋亡,在不同的癌细胞系中以 IC50 为 1.7-4.0 μM 抑制细胞增殖。 | |||
T6690 |
T0901317
N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺 |
Apoptosis; FXR; Liver X Receptor; ROR | Apoptosis; Metabolism |
T0901317 是一种口服有效且高度选择性的LXR 激动剂,对 LXRα 的EC50为 20 nM。它激活FXR,EC50为 5 μM。它是RORα和RORγ双重反向激动剂,Ki 值分别为 132 nM 和 51 nM。它诱导细胞凋亡,并抑制低密度脂蛋白受体缺失小鼠动脉粥样硬化的发展。 | |||
T10761 |
Ceranib-2
3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one |
Apoptosis; S1P Receptor | Apoptosis; GPCR/G Protein |
Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) 是一种神经酰胺酶抑制剂,在 SKOV3 细胞中的 IC50 为 28 μM。 Ceranib-2 降低鞘氨醇和 S1P 的水平,诱导细胞凋亡并表现出抗癌活性。 | |||
T39888 |
IDO1-IN-7
IDO1-IN-7 |
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IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research. | |||
T63668 | Anticancer agent 16 | ||
Anticancer agent 16 对 HCT-116 细胞系 (IC50: 8.55 μM)、NCI-H460 细胞系 (IC50: 5.41 μM) 和 SKOV3 细胞系 (IC50: 6.4 μM)表现出良好的细胞毒效果。 | |||
T36645 |
CAY10763
CAY10763 |
||
CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM... | |||
T70792 |
SPR519
|
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SPR519 is a potent dual inhibitor of PI3Kα and mTOR kinases with IC50 (PI3Kalpha) = 30 nM and IC50 (mTOR) = 10 nM. SPR519 exhibits an EC50 of low sub-micromolar range among various tested cancer cell lines such as A2780 (0.23 μM), PC3 (0.48 μM), and SKOV3 (0.50 μM). |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5755 |
Aloesin
|
Tyrosinase | Proteases/Proteasome |
Aloesin 是芦荟的活性成分之一,能够通过 MAPK 信号通路发挥抗癌作用,并具有抗炎、紫外线保护和抗菌作用。 | |||
T3923 |
Calycosin
Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮 |
Apoptosis; Tyrosinase | Apoptosis; Proteases/Proteasome |
Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。 | |||
T37543 |
Anhydroepiophiobolin A
|
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Anhydroepiophiobolin A is a sesterterpenoid fungal metabolite that has been found in B. oryzae. It is cytotoxic to HepG2 and K562 cells (IC50s = 47.1 and 35.6 μM, respectively) as well as A549, SKOV3, SK-MEL-2, XF498, and HCT15 cells (IC50s = 1.6-1.9 μg/ml). Anhydroepiophiobolin A is phytotoxic to S. viridis and D. erucoides in a leaf puncture assay. | |||
T35483 |
19,20-Epoxycytochalasin D
|
||
19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM. | |||
T37552 |
(+)-Macrosphelide A
|
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(+)-Macrosphelide A is a fungal metabolite originally isolated from Microsphaeropsis. It inhibits adhesion of HL-60 human leukemia cells to human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. It also inhibits the growth of SKOV3 ovarian cancer cells in a concentration-dependent manner. (+)-Macrosphelide A inhibits the growth of Gram-positive bacteria, including B. subtilis, M. luteus, B. thuringiensis, and S. aureus (MICs = 143, 143, 57, and 57 μg/ml, respectivel... |