Cat. No. | Product Name | Target | Signaling Pathways |
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T1829 |
Ruxolitinib
芦可替尼,INCB018424,鲁索替尼,(R)-Ruxolitinib |
Apoptosis; Mitophagy; Tyrosine Kinases; JAK; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Ruxolitinib (INCB018424) 是一种 JAK1/2 抑制剂 (IC50=3.3/2.8 nM),具有有效性和选择性。Ruxolitinib 具有抗肿瘤活性,可以诱导细胞自噬和凋亡。 | |||
T6156 |
Ruxolitinib (S enantiomer)
S-Ruxolitinib,环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯,Ruxolitinib S enantiomer,INCB018424,INCB18424 |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Ruxolitinib S enantiomer (INCB18424) 是 Ruxolitinib 的 S 型对映体,是一种JAK 抑制剂。 | |||
T3043 |
Ruxolitinib phosphate
INC424,INCB018424,INC 424 phosphate,Ruxolitinib (INCB-18424) phosphate,INCB018424 phosphate,磷酸鲁索利替尼 |
Mitophagy; JAK; Autophagy | Angiogenesis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Ruxolitinib phosphate (INCB018424) 是一种 JAK1/2抑制剂,IC50分别为3.3 nM/2.8 nM,对 JAK1/2 的选择性是 JAK3 的 130 倍以上。 | |||
T61988 |
Ruxolitinib sulfate
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Ruxolitinib sulfate (INCB018424 sulfate) 是一种有效的JAK1/2抑制剂。Ruxolitinib sulfate 抑制JAK1/2的IC50为 3.3 nM/2.8 nM,高于 JAK3 130 倍。 | |||
T2476 |
INCB032304
4-(1H-吡唑-4-基)-7-((2-(三甲基硅烷基)乙氧基)-甲基)-7H-吡咯并[2,3-D]嘧啶,4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)-methyl)-7H-pyrrolo[2,3-d]pyrimidine |
Others | Others |
INCB032304是一种重要的医药中间体。可用于制备janus 激酶抑制剂Ruxolitinib phosphate(I008849),也可于制备Barretinib。 | |||
T74994 | SJ988497 | ||
SJ988497是一种PROTACJAK2降解剂,有效地抑制CRLF2重排(CRLF2r)细胞增殖并降解CRBN新底物GSPT1。该化合物由Ruxolitinib衍生物、连接子以及CRBN配体Pomalidomide构成,可作为急性淋巴细胞白血病(ALL)研究用途。 | |||
T38158 |
StA-IFN-1
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StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective f... |