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Targets Recommended: S6 Kinase

6

抑制剂 & 化合物

2

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T6878 LJI308

S6 Kinase MAPK; PI3K/Akt/mTOR signaling
LJI308 是泛RSK 抑制剂,对 RSK1、RSK2 和 RSK3 的IC50分别为 6、4 和 13 nM。它抑制辐照、EGF 处理和表达 KRAS 突变的细胞中 RSK (T359/S363) 和 YB-1 (S102) 的磷酸化。
T14779 BRD7389

SGK; FLT; Pim; CDK; S6 Kinase; DAPK Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
BRD7389 是一种 RSK 家族激酶抑制剂,对 RSK1、RSK2 和 RSK3 的 IC50 分别为 1.5 μM、2.4 μM 和 1.2 μM。
T6171 BI-D1870

S6 Kinase; Autophagy Autophagy; MAPK; PI3K/Akt/mTOR signaling
BI-D1870 是一种可渗透细胞和透过血脑屏障的的 ATP 竞争性核糖体 S6 激酶抑制剂,抑制 RSK1、RSK2、RSK3RSK4 的 IC50值分别为 31 nM、24 nM、18 nM 和15 nM。
T6948 Pluripotin

SC1

ERK; Raf; S6 Kinase MAPK; PI3K/Akt/mTOR signaling
Pluripotin (SC1) 是ERK1和RasGAP 的双重抑制剂,KD 分别为 98 和 212 nM。它还抑制RSK1、RSK2、RSK3RSK4,IC50分别为 0.5、2.5、3.3 和 10.0 μM。
T60585 RSK2-IN-2

RSK2-IN-2 (Compound 25) 是 RPS6KA3 (RSK2) 激酶的可逆共价抑制剂,它也能抑制MSK1、MSK2和RSK3
T6877 LJH685

Apoptosis; S6 Kinase Apoptosis; MAPK; PI3K/Akt/mTOR signaling
LJH685 是一种选择性,ATP-竞争性的RSK 抑制剂, 抑制 RSK1/2/3 生物活性,IC50为 6、5、4 nM。

化合物

LJI308
Cat.No: T6878
Synonym:
Target: S6 Kinase
BRD7389
Cat.No: T14779
Synonym:
Target: SGK, FLT, Pim, CDK, S6 Kinase, DAPK
BI-D1870
Cat.No: T6171
Synonym:
Target: S6 Kinase, Autophagy
Pluripotin
Cat.No: T6948
Synonym: SC1
Target: ERK, Raf, S6 Kinase
RSK2-IN-2
Cat.No: T60585
Synonym:
Target:
LJH685
Cat.No: T6877
Synonym:
Target: Apoptosis, S6 Kinase
Cat. No. Product Name Species Expression System
TMPY-04392 RSK3 Protein, Human, Recombinant (GST)

HU-2,ribosomal protein S6 kinase, 90kDa, polypeptide 2,S6K-α...

Human Baculovirus Insect Cells
Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 a...
TMPH-01692 MAPK3 Protein, Human, Recombinant (His)

Human E. coli
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...

重组蛋白

RSK3 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04392
Species: Human
Expression System: Baculovirus Insect Cells
MAPK3 Protein, Human, Recombinant (His)
Cat.No: TMPH-01692
Species: Human
Expression System: E. coli
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