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Search Results for " rcc "

11

抑制剂 & 化合物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T71029	RCC-36 HCl
	Rcc 36 is an active metabolite of temiverine that has inhibitory actions toward the atropine-resistant part of contractions, which may be related to the calcium antagonistic actions of these compounds.
T26046	Razoxane	Topoisomerase	DNA Damage/DNA Repair
	Razoxane 是拓扑异构酶 II 的有效抑制剂，具有抗血管生成的作用，在肾细胞癌中具有研究价值。
T6683	STF-62247 STF 62247	Estrogen/progestogen Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	STF-62247 是一种自噬诱导剂，在 RCC4 和 RCC4/VHL 细胞中的IC50分别为 0.625 μM 和 16 μM。它对 VHL 缺陷型肾细胞癌有选择性的细胞毒性。
T9698	UC2288	Mdm2; p53	Apoptosis
	UC2288 是新型的、细胞通透性、口服有效的p21衰减试剂，基于索拉非尼的结构合成。在不依赖于p53的情况下，它可以下调 p21 mRNA 的表达，降低 p21 蛋白水平，对 p21 蛋白的稳定性影响很小。它对VEGFR2 和 Raf 激酶没有抑制作用，即使在 10 μM。
T71027	KDI-792 hydrochloride
	KDI-792 hydrochloride is a thromboxane dual blocker.
T60904	ERCC1-XPF-IN-2	Others	Others
	ERCC1-XPF-IN-2 在核苷酸切除修复、顺铂增强和 γH2AX 测定中具有活性。ERCC1-XPF-IN-2 是 ERCC1-XPF 核酸内切酶的有效抑制剂，IC50值为 0.6 μM。
T41227	ARCC 4 negative control
	ARCC 4 negative control is a negative control for ARCC 4. Binds androgen receptors (AR) without inducing degradation.
T14318	ARCC-4	Others	Others
	ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide and it is a low-nanomolar androgen receptor (AR) degrader based on PROTAC, with a DC50 of 5 nM. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy[1].
T63464	ERCC1-XPF-IN-1
	ERCC1-XPF-IN-1 是有效的、高亲和力的 ERCC1-XPF 抑制剂 (IC50: 0.49 μM)。ERCC1-XPF-IN-1 能够抑制 CPDs 的去除，降低环磷酰胺对结直肠癌细胞的毒性，提高了 UV 辐射的细胞毒性作用，阻碍 DNA 修复。
T63505	Tivozanib hydrochloride hydrate AV-951 hydrochloride hydrate,KRN951 hydrochloride hydrate	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Tivozanib hydrochloride hydrate (AV-951 hydrochloride hydrate) 是一种具有口服活性、选择性和高效性的血管内皮生长因子受体（VEGFR）酪氨酸激酶抑制剂，抑制 VEGFR-1、VEGFR-2、VEGFR-3 ,可用于研究转移性肾细胞癌 (RCC)和乳腺癌等实体肿瘤疾病。
T76723	Tilvestamab
	Tilvestamab (BGB149) 是一种人源化抗AXL 抗体，阻断AXL 介导的细胞信号传导。Tilvestamab 在体外能显著抑制Gas6刺激诱导的AXL 激活，并抑制 786-0-Luc RCC 细胞中下游AXL 的磷酸化。Tilvestamab 可用于癌症，尤其是AXL 过度表达肾细胞癌的研究。

化合物

Cat.No: T71029

Cat.No: T26046

Target: Topoisomerase

Cat.No: T6683

Synonym: STF 62247

Target: Estrogen/progestogen Receptor, Autophagy

Cat.No: T9698

Target: Mdm2, p53

KDI-792 hydrochloride

Cat.No: T71027

Cat.No: T60904

Target: Others

ARCC 4 negative control

Cat.No: T41227

Cat.No: T14318

Target: Others

Cat.No: T63464

Tivozanib hydrochloride hydrate

Cat.No: T63505

Synonym: AV-951 hydrochloride hydrate,KRN951 hydrochloride hydrate

Target: VEGFR

Cat.No: T76723

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00283	Carbonic Anhydrase 9 Protein, Human, Recombinant (Avi & His), Biotinylated G250,P54/58N,Carbonic Anhydrase IX,CA9,Carbonate dehydratase...	Human	HEK293 Cells
	Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA9 is a transmembrane enzyme expressed primarily in carcinoma cells. It is one of the best markers for hypoxia and for RCC...
TMPK-00283	CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi) RCC,EC 4.2.1.1,CA9,P54/58N,MN,CA-IX,CAIX,G250,PMW1	Human	HEK293 Cells
	CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The...
TMPK-00524	CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His) CAIX,CA9,P54/58N,RCC,G250,EC 4.2.1.1,PMW1,CA-IX,MN	Cynomolgus	HEK293 Cells
	CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The pred...
TMPK-00478	Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His) CA12,CAXII,Carbonic anhydrase,CA-XII,Tumor antigen HOM-R...	Cynomolgus	HEK293 Cells
	Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Carbonic anhydrase XII (CA XII) is a key mediator of several signaling pathways that are involved in cancer development.
TMPH-02159	SMARCC1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	SMARCC1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.5 kDa and the accession number is Q92922.
TMPH-01380	ERCC3 Protein, Human, Recombinant (GST)	Human	E. coli
	ERCC3 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 115.6 kDa and the accession number is P19447.
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus Insect Cells
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...
TMPH-01621	BRCC3 Protein, Human, Recombinant (His & SUMO) BRCC36,CXorf53,C6.1A,BRCC3,BRCA1/BRCA2-con...	Human	E. coli
	Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, anta...
TMPY-01763	Cadherin 16/CDH16 Protein, Human, Recombinant (His) UNQ695/PRO1340,cadherin 16	Human	HEK293 Cells
	KSP-Cadherin/Cadherin-16 is a member of the cadherin superfamily, calcium-dependent, membrane-associated glycoproteins. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playi...

重组蛋白

Carbonic Anhydrase 9 Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00283

Species: Human

Expression System: HEK293 Cells

CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00283

Species: Human

Expression System: HEK293 Cells

CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00524

Species: Cynomolgus

Expression System: HEK293 Cells

Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00478

Species: Cynomolgus

Expression System: HEK293 Cells

SMARCC1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02159

Species: Human

Expression System: E. coli

ERCC3 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01380

Species: Human

Expression System: E. coli

XRCC5 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPH-02314

Species: Human

Expression System: Baculovirus Insect Cells

XRCC5 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02315

Species: Human

Expression System: E. coli

BRCC3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01621

Species: Human

Expression System: E. coli

Cadherin 16/CDH16 Protein, Human, Recombinant (His)

Cat.No: TMPY-01763

Species: Human

Expression System: HEK293 Cells

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