7
4
37
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62189 |
sRANKL-IN-1
|
||
sRANKL-IN-1 (compound S3) 是一种 sRANKL (soluble RANKL) 的抑制剂。sRANKL-IN-1 能够较强的抑制破骨细胞 (IC50: 0.096 μM,Kd: 34.80 μM)。sRANKL-IN-1 能够用于研究骨质疏松症。 | |||
T25859 |
Necrostatin-7
Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7 |
Apoptosis | Apoptosis |
Necrostatin-7 (Necrostatin 7) 是一种坏死性凋亡抑制剂,具有心脏保护作用,可抑制 RANK-NFATc1 信号传导并减弱巨噬细胞向破骨细胞的分化。 | |||
T9917 |
Denosumab
|
RANKL/RANK | NF-κB |
Denosumab 是能够结合并抑制RANKL 受体激活因子的人单克隆抗体。它具有抗癌活性,可降髋部、低椎骨以及非椎骨骨折的风险。 | |||
T38129 |
Leukotriene F4
LTF4 |
||
LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle. [1] The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4. [1] [2] | |||
T36127 |
TNF-α Antagonist
|
||
TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destr... | |||
T70049 |
Ro 04-5595 free base
|
||
Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol/L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific binding, defined with a new NR2B-specific antagonist Ro 04-5595 at 10 microM was fully inhibited by several compounds with the following rank order of affinities--Ro 25-6981 > CP-101,606 > Ro 04-5595 = ifenprodil >> eliprodil > haloperidol > spermine > spermidine > MgCl2 > CaCl2--and... | |||
T80195 |
Garvicin KS, GakB
|
||
Garvicin KS(GakB)是由34个氨基酸组成的肽,与GakA和GakC共同构成细菌素GarKS。该肽不仅能抑制成纤维细胞活力和增殖,还表现出与GakA组合时的优异稳定性、抗菌效能以及对成纤维细胞作用。针对MSSA的抑制,Garvicin KS肽的MIC值显示GakB的活性最强,其次为GakC,GakA活性最低。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5528 |
Cyanidin Chloride
|
Antioxidant | oxidation-reduction |
Cyanidin Chloride 是一种花青素的亚类,具有抗氧化和抗癌活性。它能够抑制破骨细胞形成,羟基磷灰石吸收和 NF-κB 配体 (RANKL) 诱导的破骨细胞标记基因表达的受体激活。 | |||
TN2586 | 11-Hydroxyrankinidine | Others | Others |
11-Hydroxyrankinidine 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2586,CAS号为 122590-03-8。 | |||
T34259 |
Rankinidine
|
||
Rankinidine, as an oxindole alkaloid, is isolated from Gelsemium rankinii. | |||
T5720 |
Boldine
1,10-Dimethoxy-2,9-dihydroxyaporphine,波尔定碱,波尔定,ex Peumus boldus |
RANKL/RANK | NF-κB |
Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) 是一种阿扑吗啡异喹啉生物碱,从山苍子根中提取获得,具有抗氧化、抗炎和细胞保护的活性。它能够抑制破骨细胞生成,并利用下调 OPG/RANKL/RANK 信号途径,改善骨破坏。它可用于研究类风湿性关节炎。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04142 |
RANK/TNFRSF11A Protein, Human, Recombinant (hFc)
OPTB7,OFE,OSTS,LOH18CR1,FEO,TRANCER,tumor necrosis factor re... |
Human | HEK293 |
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this recep... | |||
TMPY-05514 |
RANK/TNFRSF11A Protein, Human, Recombinant (mFc)
OFE,RANK,OPTB7,FEO,tumor necrosis factor receptor s... |
Human | HEK293 |
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this recep... | |||
TMPK-00723 |
RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc)
CD265,Rank,FEO,ODFR,NF-KB,OSTS,TNFRSF11A,OPTB7,NFKB... |
Mouse | HEK293 |
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. | |||
TMPY-04157 |
RANK/TNFRSF11A Protein, Human, Recombinant (His)
ODFR,OFE,CD265,PDB2,RANK,tumor necrosis factor rece... |
Human | HEK293 |
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this recep... | |||
TMPK-00351 |
RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc)
NF-KB,ODFR,PDB2,Rank,OSTS,NFKB,OPTB7,TNFRSF11A,LOH1... |
Human | HEK293 |
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. | |||
TMPJ-00662 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
Receptor activator of nuclear factor kappa-B ligand,Receptor... |
Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog... | |||
TMPJ-00349 |
RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)
CD265 antigen,FEO,TRANCER,ODFR,ODFROSTS,TRANCE R,TNFRSF11A,O... |
Human | Human Cells |
Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutive... | |||
TMPY-03026 |
RANK/TNFRSF11A Protein, Rat, Recombinant (hFc)
TNFRSF11A,tumor necrosis factor receptor superfamily member ... |
Rat | HEK293 |
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this recep... | |||
TMPJ-00674 |
RANK/TNFRSF11A Protein, Mouse, Recombinant (His)
Receptor activator of NF-KB,TNFRSF11A,Osteoclast differentia... |
Mouse | Human Cells |
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br... | |||
TMPY-02851 |
RANK/TNFRSF11A Protein, Rat, Recombinant (His)
tumor necrosis factor receptor superfamily member 11a,TNFRSF... |
Rat | HEK293 |
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this recep... | |||
TMPY-03364 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant
sOdf,OPTB2,TNFSF11,TRANCE,hRANKL2,ODF,OPGL,RANK... |
Human | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane protein that belongs to the tumor necrosis factor family. The receptor activator of nuclear factor-kappaB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. R... | |||
TMPY-03674 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc)
sOdf,tumor necrosis factor (ligand) superfamily, member 11,T... |
Human | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane protein that belongs to the tumor necrosis factor family. The receptor activator of nuclear factor-kappaB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. R... | |||
TMPY-02726 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)
RANKL,OPGL,Trance,OPG,tumor necrosis factor (ligand... |
Mouse | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane protein that belongs to the tumor necrosis factor family. The receptor activator of nuclear factor-kappaB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. R... | |||
TMPJ-00607 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)
Receptor activator of nuclear factor κ-B ligand,Osteoprotege... |
Mouse | Human Cells |
Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This cytokine can bind to TNFRSF11B/OPG andTNFRSF11A/RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune respo... | |||
TMPK-00591 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (aa 70-316, His)
CD254,OPGL,TNFSF11,TRANCE,ODF,sOdf,OPTB2,RANKL |
Mouse | HEK293 |
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL and RANK are under the tight control of the female sex hormones estradiol and progesterone. | |||
TMPK-00716 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244)
OPGL,TRANCE,OPTB2,TNFSF11,ODF,sOdf,RANKL,CD254 |
Human | HEK293 |
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL and RANK are under the tight control of the female sex hormones estradiol and progesterone. | |||
TMPK-00717 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag)
OPGL,CD254,TRANCE,ODF,RANKL,TNFSF11,OPTB2,sOdf |
Human | HEK293 |
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL and RANK are under the tight control of the female sex hormones estradiol and progesterone. | |||
TMPY-00537 |
RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc)
tumor necrosis factor (ligand) superfamily, member 11 |
Cynomolgus | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane protein that belongs to the tumor necrosis factor family. The receptor activator of nuclear factor-kappaB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. R... | |||
TMPY-06561 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (rFc)
OPTB2,OPGL,hRANKL2,CD254,sOdf,tumor necrosis factor... |
Human | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane protein that belongs to the tumor necrosis factor family. The receptor activator of nuclear factor-kappaB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. R... | |||
TMPY-01471 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (hFc)
TRANCE,sOdf,CD254,hRANKL2,TNFSF11,ODF,OPTB2,tumor n... |
Human | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane protein that belongs to the tumor necrosis factor family. The receptor activator of nuclear factor-kappaB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. R... | |||
TMPY-03527 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc)
CD254,tumor necrosis factor (ligand) superfamily, member 11,... |
Human | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane protein that belongs to the tumor necrosis factor family. The receptor activator of nuclear factor-kappaB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. R... | |||
TMPJ-01472 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)
|
Mouse | Human Cells |
Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This cytokine can bind to TNFRSF11B/OPG andTNFRSF11A/RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune respo... | |||
TMPJ-01466 |
Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
OPG,Tumor Necrosis Factor Receptor Superfamily Member 11B,OC... |
Human | Human Cells |
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF... | |||
TMPH-01294 |
EDNRA Protein, Human, Recombinant (His)
ET-A,Endothelin-1 receptor,hET-AR,ETA-R,ETRA,EDNRA,ETA |
Human | Yeast |
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. | |||
TMPH-02147 |
TACR1 Protein, Human, Recombinant (GST)
|
Human | E. coli |
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. | |||
TMPH-01767 |
NPY2R Protein, Human, Recombinant (His)
|
Human | in vitro E. coli expression system |
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. | |||
TMPH-03749 |
CYSLTR1 Protein, Human, Recombinant (His)
Cysteinyl leukotriene receptor 1,G-protein coupled receptor ... |
Human | in vitro E. coli expression system |
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. | |||
TMPJ-00434 |
Siglec-15 Protein, Cynomolgus, Recombinant (His)
Siglec-15,CD33L3,Sialic acid-binding Ig-like lectin 15,CD33 ... |
Cynomolgus | Human Cells |
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type I... | |||
TMPH-02960 |
TNFSF11 Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multipl... | |||
TMPH-02210 |
TRAF6 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to... | |||
TMPJ-00217 |
Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated
CD33L3,Siglec-15,Sialic acid-binding Ig-like lectin 15,CD33 ... |
Human | Human Cells |
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type I... | |||
TMPH-02264 |
TNFSF11 Protein, Human, Recombinant (His)
|
Human | HEK293 |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multipl... | |||
TMPJ-00253 |
OPG Protein, Mouse, Recombinant (His)
Opg,Ocif,Tnfrsf11b,Osteoclastogenesis inhibitory factor,Oste... |
Mouse | Human Cells |
Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG ... | |||
TMPH-02417 |
Albumin Protein, Cynomolgus, Recombinant (His & Myc)
ALB |
Cynomolgus | HEK293 |
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site b... | |||
TMPH-00301 |
Serum albumin Protein, Bovine, Recombinant (His & Myc)
|
Bovine | Yeast |
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared bin... | |||
TMPJ-00225 |
Siglec-15 Protein, Mouse, Recombinant (His)
Siglec-15,Sialic acid-binding Ig-like lectin 15,CD33L3,CD33 ... |
Mouse | Human Cells |
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type I... | |||
TMPH-02416 |
Albumin Protein, Macaca fascicularis, Recombinant (Yeast, His)
ALB |
Cynomolgus | Yeast |
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site b... |