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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8871	C/EBPα inducer 1 4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-	Others	Others
	C/EBPα inducer 1 (4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-) 是一种C/EBPα和骨髓细胞分化的诱导剂。
T24879	Thioxodihydroquinazolinone-19 Thioxodihydroquinazolinone19
	In platinum-resistant A2780cis human ovarian cancer cells, thioxodihydroquinazolinone-19 is an inducer of apoptotic cell death. It acts by exhibiting a strong inhibitory effect in ovarian CSC-LCs in combination with cisplatin.
T2103	Ispinesib 伊匹尼塞,伊斯平斯,CK0238273,SB-715992	Apoptosis; Kinesin; KSP	Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling
	Ispinesib (SB-715992) 是一种选择性可逆的驱动蛋白纺锤体蛋白抑制剂，具有抗肿瘤特性。
T8785	HALOFUGINONE LACTATE	DNA/RNA Synthesis; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Stem Cells
	HALOFUGINONE LACTATE 是 febrifugine 的卤化衍生物，它是一种天然的含有喹唑啉酮的化合物，存在于中草药 D. febrifuga 中。Halofuginone 以 ATP 依赖性方式抑制脯氨酰-tRNA 合成酶，Ki 为 18.3 nM。 Halofuginone 是 I 型胶原合成的特异性抑制剂，通过抑制 TGF-β 活性来减轻骨关节炎 (OA)
T25431	Fluproquazone Tormosyl,46 790,46-790
	Fluproquazone is a quinazolinone derivative with potent antipyretic, analgesic, and anti-inflammatory effects. However, it was withdrawn during development due to liver toxicity.
T71574	Mci 176
	Mci 176 is a quinazolinone calcium antagonist.
T83074	Anticancer agent 95
	Anticancer agent 95（compound 24）为一类具抗癌活性的喹唑啉酮化合物。
T4993	Afloqualone 氟喹酮,HQ-495	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Afloqualone (HQ-495) 是一种 GABA 受体激动剂。靶点:体外 GABA 受体:Afloqualone 是一种喹唑啉酮家族 GABA 能药物。由于其在 GABAa 受体β亚型的激动剂活性，它具有镇静和肌肉松弛作用。

化合物

C/EBPα inducer 1

Cat.No: T8871

Synonym: 4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-

Target: Others

Thioxodihydroquinazolinone-19

Cat.No: T24879

Synonym: Thioxodihydroquinazolinone19

Target:

Ispinesib

Cat.No: T2103

Synonym: 伊匹尼塞,伊斯平斯,CK0238273,SB-715992

Target: Apoptosis, Kinesin, KSP

HALOFUGINONE LACTATE

Cat.No: T8785

Synonym:

Target: DNA/RNA Synthesis, TGF-beta/Smad

Fluproquazone

Cat.No: T25431

Synonym: Tormosyl,46 790,46-790

Synonym: 氟喹酮,HQ-495

Target: GABA Receptor

Cat. No.	Product Name	Target	Signaling Pathways
TMO2713	4(3H)-Quinazolinone Quinazolin-4-ol,4-Hydroxyquinazoline,4-羟基喹唑啉,4-Quinazolinol,4-Quinazolone,4-Quinazolinone	Antibacterial; Platelet aggregation	Microbiology/Virology; Others
	4(3H)-Quinazolinone (4-Hydroxyquinazoline) 是化学合成中的砌块，是一种生物活性氮杂环化合物。它具有多种生物学特性，如抗菌，抗真菌，抗惊厥，抗炎，抗 HIV，抗癌和缓解疼痛活性。
TN1012	Febrifugine	IL Receptor; Anti-infection; Parasite	Immunology/Inflammation; Microbiology/Virology
	Febrifugine 是存在于常山的根和叶中的一种喹唑啉酮类生物碱，有抗疟活性。它是一种有效的抗球虫药，具有杀灭裂殖体的作用。
TN1012L	Febrifugine dihydrochloride ISF-2123,Propyldazine hydrochloride,Atensil,(+)-Febrifugine dihydrochloride,常山乙素二盐酸盐,Pildralazine dihydrochloride	Parasite	Microbiology/Virology
	Febrifugine dihydrochloride (Propyldazine hydrochloride) 是存在于常山的根和叶中的一种喹唑啉酮类生物碱，具有治疗疟疾、癌症、纤维化和炎症性疾病的活性。
T3524	Halofuginone hydrobromide 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐	Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells
	Halofuginone hydrobromid 是Febrifugine 的衍生物，是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂，并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。