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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T24654	PPT
	PPT is a modulator of water-heme interactions of CYP2C9d and CYP125A1 in low-spin P450 complexes.
T16566	Propyl pyrazole triol PPT	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Propyl pyrazole triol (PPT) 是雌激素受体 α(ERα)选择性激动剂。它对 ERα 的相对结合亲和力 (ERα: 49%) 比雌激素受体 β (ERβ: 0.12%) 高 410 倍。
T63534	PPTN hydrochloride	P2Y Receptor	GPCR/G Protein; Neuroscience
	PPTN hydrochloride 是有效的、高亲和力的、竞争性的、高度选择性的P2Y14受体拮抗剂 (KB: 434 pM)，但 P2Y1，P2Y2，P2Y4，P2Y6，P2Y11，P2Y12 或 P2Y13 受体无激动剂或拮抗剂活性，表现出抗炎和抗免疫作用。
T78714	PptT-IN-4	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	PptT-IN-4 (Compound 3a) 为PptT抑制剂，IC50为0.71 μM。其对MtbH37Rv的MIC值为42 μM，并且还能抑制hERG、hCav1.2和hNav1.5通道，对应IC50s分别为11 μM、8.1 μM、6.9 μM。
T12530	PPTN	P2Y Receptor	GPCR/G Protein; Neuroscience
	PPTN 是一种有效，高亲和力，竞争性和高选择性的 P2Y14 受体拮抗剂，KB 为 434 pM。PPTN 对 P2Y1，P2Y2，P2Y4，P2Y6，P2Y11，P2Y12 或 P2Y13 受体无激动剂或拮抗剂作用。具有抗炎和免疫活性。
T24655	PPTN Mesylate PPTN Mesylate salt
	PPTN Mesylate is an effective and highly selective antagonist of the P2Y14 receptor.
T61847	PptT-IN-2
	PptT-IN-2 (compound 5k) is a highly effective inhibitor of phosphopantetheinyl phosphoryl transferase (PptT), with an IC50 of 2.5 μM. PptT is an indispensable enzyme crucial for synthesizing cellular lipids and virulence factors in Mycobacterium tuberculosis. Therefore, PptT-IN-2 holds great promise for further investigations into tuberculosis research [1].
T31550	DMA-CPPTL DMACPPTL,DMA CPPTL
	DMA-CPPTL is a prodrug of CPPTL which induces apoptosis in a dose-dependent manner via the ROS/JNK pathway in acute myeloid leukemia.
T61466	PptT-IN-3
	PptT-IN-3 (compound 5p) is a powerful inhibitor (IC 50 = 3.5 μM) of phosphopantetheinyl phosphoryl transferase (PptT), an indispensable enzyme involved in the synthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. This compound, PptT-IN-3, holds promise for tuberculosis research [1].
T61167	PptT-IN-1
	PptT-IN-1 (compound 5j) is a highly potent inhibitor (IC50: 2.8 μM) of phosphopantetheinyl phosphoryl transferase (PptT), a crucial enzyme involved in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. This compound shows considerable potential for tuberculosis research [1].
T37191	Mu-6S-Palm-β-Glc
	Mu-6S-Palm-β-Glc is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. Mu-6S-Palm-β-Glc is cleaved by PPT/CLN1 to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM...

化合物

Propyl pyrazole triol

Cat.No: T16566

Synonym: PPT

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

PPTN hydrochloride

Cat.No: T63534

Synonym:

Target: P2Y Receptor

PptT-IN-4

Cat.No: T78714

Synonym:

Target: Calcium Channel

PPTN

Cat.No: T12530

Synonym:

Target: P2Y Receptor

PPTN Mesylate

Cat.No: T24655

Synonym: PPTN Mesylate salt

Synonym: DMACPPTL,DMA CPPTL

Cat. No.	Product Name	Target	Signaling Pathways
T2810	(20S)-Protopanaxatriol 原人参三醇,20(S)-APPT,20 (S)-原人参三醇,g-PPT	Apoptosis; Estrogen Receptor/ERR; Glucocorticoid Receptor; Estrogen/progestogen Receptor; Liver X Receptor	Apoptosis; Endocrinology/Hormones; Metabolism
	(20S)-Protopanaxatriol (g-PPT) 是人参皂苷的代谢物，通过糖皮质激素受体和雌激素受体起作用，同时为LXRα的抑制剂，具有广泛的抗癌活性。

天然产物

(20S)-Protopanaxatriol

Cat.No: T2810

Synonym: 原人参三醇,20(S)-APPT,20 (S)-原人参三醇,g-PPT

Target: Apoptosis, Estrogen Receptor/ERR, Glucocorticoid Receptor, Estrogen/progestogen Receptor, Liver X Receptor

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