Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71993 |
PKC-9
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PKC-9 is a PKC-zeta inhibitor 9. | |||
T71401 | Oxaliplatin-d10 | ||
Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.... | |||
T16104 |
ML-9
|
Myosin; Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
ML-9 是 Akt 激酶的一种选择性强效抑制剂,可抑制肌球蛋白轻链激酶 (MLCK) 和基质相互作用分子1(STIM1) 活性。它通过刺激自噬小体的形成并抑制其降解来诱导自噬。它抑制 MLCK,PKA 和 PKC 活性,Ki 值分别为 4、32 和 54 μM。 | |||
T6285 |
GSK-690693
GSK690693 |
Serine Protease; Akt; PKC; AMPK; Autophagy | Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
GSK-690693 是一种泛 Akt 抑制剂,对 Akt1、Akt2和 Akt3的 IC50分别为 2 nM、13 nM 和9 nM。它也是一种 AMPK 的抑制剂,影响 ULK1 的活性,并能显著抑制 STING 依赖的 IRF3 的激活。 | |||
T6458 |
CYC-116
噻氯匹定 |
VEGFR; FLT; CDK; S6 Kinase; Aurora Kinase | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
CYC116是一种有效的极光激酶 A 和 B 的抑制剂,Ki 值分别为8和9 nM。 | |||
T16103 |
ML-9 Free Base
|
Others | Others |
ML-9 (free base) suppresses MLCK, PKA, and PKC activity (Ki: 4, 32, and 54 μM, respectively). ML-9 (free base) is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) acti | |||
T36228 |
Bisindolylmaleimide XI hydrochloride
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Bisindolylmaleimide XI hydrochloride 是一种具有口服活性的 PKC 抑制剂,对 PKCα、PKCβI、PKCβII、PKCγ 具有抑制作用(IC50s 分别为 9 nM、28 nM、31 nM、37 nM 和 108 nM)。 | |||
T35423 |
7-oxo Staurosporine
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7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits gr... |