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Search Results for " pcs "

Targets Recommended: Others

19

抑制剂 & 化合物

2

天然产物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16443	PCS1055 dihydrochloride	Others	Others
	PCS1055 dihydrochloride is an effective, selective, and competitive muscarinic M4 receptor antagonist (IC50: 18.1 nM and a Kd: 5.72 nM). PCS1055 dihydrochloride is also a potent AChE inhibitor (IC50 s: 22 nM and 120 nM for electric eel and human AChE, res
T67776	PCSK9-IN-11	Others	Others
	PCSK9-IN-11 (compound 5r) 是口服有效的 PCSK9 抑制剂。 PCSK9-IN-11 在 HepG2 细胞中抑制 PCSK9 转录活性 (IC50= 5.7 μM)。 PCSK9-IN-11 可以增加 LDL 受体 (LDLR) 蛋白水平，可用于动脉粥样硬化研究。
T72025	PCSK9-IN-10	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	PCSK9-IN-10 是一种有效的，具有口服活性的PCSK9抑制剂，IC50值为 6.4 µM。PCSK9-IN-10 增加LDLR 蛋白的表达并降低 PCSK9 的表达。PCSK9-IN-10 可减缓动脉粥样硬化进展。PCSK9-IN-10 具有研究高脂血症的潜力。
T60646	PCSK9 modulator-3
	PCSK9 modulator-3 (Compound 13) 是PCSK9的有效调节剂，EC50值为 2.46 nM，在高脂血症研究中具有潜力。PCSK9 是已证实的降低低密度脂蛋白胆固醇 (LDL-C) 的靶点。
T73008	PCSK9-IN-13
	PCSK9-IN-13 是一种有效的PCSK9抑制剂，可通过与 PCSK9 结合作用来拮抗低密度脂蛋白(LDL) 受体结合，其IC50值为 537 nM。
T81535	PCSK9-IN-20
	PCSK9-IN-20（Compound 3i）作为一种PCSK9抑制剂，具有IC50为 3.96 µM，能有效降低体外PCSK9水平并提升LDLR蛋白表达。
T39528	PCSK9-IN-2 PCSK9-IN-2
	PCSK9-IN-2 is a newly developed small molecule that effectively inhibits the protein-protein interaction (PPI) between PCSK9 and LDLR. It has been found to have a potent inhibitory activity with an IC50 value of 7.57 μM.
T13813	PCSK9 ligand 1	Others	Others
	PCSK9 ligand 1 is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9(Ki of 107 nM).
T79052	PCSK9-IN-16
	PCSK9-IN-16，有效的PCSK9抑制剂，用于治疗高胆固醇血症及其他心血管疾病。
T79239	PCSK9-IN-19
	PCSK9-IN-19 (Compound 1)作为一种PCSK9抑制剂，用于研究高LDL胆固醇水平及预防冠状动脉疾病。
T60541	PCSK9 modulator-2
	PCSK9 modulator-2 (Compound 1) 是一种有效的PCSK9调节剂（EC50 = 202 nM），具有用于高脂血症的研究潜力。PCSK9 是降低低密度脂蛋白胆固醇 (LDL-C) 的靶点。
T74167	PCSK9-IN-3
	PCSK9-IN-3为新一代口服高效三环肽类PCSK9抑制剂，特征为新型化合物。
T29890	AlPcS4 Aluminum phthalocyanine tetrasulfonate tetrasodium,Chloroaluminum tetrasulfophthalocyanine
	AlPcS4 , also known as aluminum phthalocyanine tetrasulfonate Chloroaluminum tetrasulfophthalocyanine; or AlS4Pc, AlPcS4(a), is a potent photosensitizer, and is potentially useful in cancer sonodynamic therapy and cancer photodynamic therapy. Aluminum pht
T79030	PCSK9-IN-14
	PCSK9-IN-14 (compound Ia-8)为高效的PCSK9抑制剂。
T39685	PCSK9 degrader 1
	PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function.
T75147	PCSK9-IN-18
	PCSK9-IN-18 (compound 188)是一种有效的 PCSK9抑制剂，KD 值为 <200 nM[1]。
T79053	PCSK9-IN-17
	PCSK9-IN-17作为PCSK9抑制剂，主要应用于胆固醇代谢研究。
T79051	PCSK9-IN-15
	PCSK9-IN-15（化合物5）是一种高效PCSK9抑制剂，亲和力强（KD<200 nM）。该化合物与胆固醇代谢相关，可调控低密度脂蛋白胆固醇（LDL-C）水平，适用于研究降低胆固醇及血脂异常。
T60764	PCSK9 modulator-4
	PCSK9 modulator-4 (Compound 21) 是可以用于高血脂研究的，PCSK9的有效调节剂 (EC 50 = 0.15 nM)。PCSK9 是得到验证的一种降低低密度脂蛋白胆固醇 (LDL-C) 的靶标。

化合物

PCS1055 dihydrochloride

Cat.No: T16443

Target: Others

Cat.No: T67776

Target: Others

Cat.No: T72025

Target: Serine/threonin kinase

PCSK9 modulator-3

Cat.No: T60646

Cat.No: T73008

Cat.No: T81535

Cat.No: T39528

Synonym: PCSK9-IN-2

PCSK9 ligand 1

Cat.No: T13813

Target: Others

Cat.No: T79052

Cat.No: T79239

PCSK9 modulator-2

Cat.No: T60541

Cat.No: T74167

Cat.No: T29890

Synonym: Aluminum phthalocyanine tetrasulfonate tetrasodium,Chloroaluminum tetrasulfophthalocyanine

Cat.No: T79030

PCSK9 degrader 1

Cat.No: T39685

Cat.No: T75147

Cat.No: T79053

Cat.No: T79051

PCSK9 modulator-4

Cat.No: T60764

Cat. No.	Product Name	Target	Signaling Pathways
T75545	PCSK9-IN-9
	PCSK9-IN-9 是一种天然来源的异香豆素。PCSK9-IN-9 可抑制原蛋白转化酶枯草菌素 kexin 型 9 (PCSK9)、IDOL 和 SREBP2的 mRNA 表达水平。PCSK9-IN-9 抑制 PCSK9的 IC50为 11.9 μM。
T5692	Pyrroloquinoline quinone	Others; Endogenous Metabolite	Metabolism; Others
	Pyrroloquinoline quinone 是氧化还原辅助因子，一种阴离子型氧化还原循环原醌。它是哺乳动物的必需营养素，对免疫功能很重要。它是从嗜甲基细菌的培养物中分离的，也存在于哺乳动物的组织。

天然产物

Cat.No: T75545

Pyrroloquinoline quinone

Cat.No: T5692

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00722	Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, hFc) PCS,contactin 3 (plasmacytoma associated),BIG-1,PAN...	Human	HEK293 Cells
	Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 134.5 kDa and the accession number is Q9P232.
TMPY-00723	Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, His) BIG-1,PCS,contactin 3 (plasmacytoma associated),PAN...	Human	HEK293 Cells
	Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 109.2 kDa and the accession number is Q9P232.
TMPY-05131	PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated NARC-1,PC9,LDLCQ1,NARC1,FH3,proprotein convertase subtilisin...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 74.3 kDa and the accession number is Q8NBP7-1.
TMPY-00408	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) FH3,proprotein convertase subtilisin/kexin type 9,LDLCQ1,HCH...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is AAV67948.1.
TMPY-04966	PCSK9 Protein, Human, Recombinant (D374Y, His) LDLCQ1,NARC-1,PC9,NARC1,HCHOLA3,proprotein convertase subtil...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.5 kDa and the accession number is Q8NBP7-1.
TMPY-05270	PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated FH3,NARC-1,PC9,LDLCQ1,proprotein convertase subtilisin/kexin...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPJ-00368	PCSK9 Protein, Human, Recombinant (Avi), Biotinylated Subtilisin/Kexin-Like Protease PC9,PC9,NARC-1,Proprotein Con...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19&65 KDa and the accession number is Q8NBP7.
TMPY-01635	PCSK1 Protein, Human, Recombinant (His) proprotein convertase subtilisin/kexin type 1,SPC3,PC1,BMIQ1...	Human	HEK293 Cells
	Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleav...
TMPY-05217	PCSK9 Protein, Mouse, Recombinant (mFc) HCHOLA3,Narc1,AI415265,AI747682,FH3,proprotein convertase su...	Mouse	HEK293 Cells
	PCSK9 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.6 kDa and the accession number is Q80W65.
TMPY-01245	PCSK9 Protein, Mouse, Recombinant (His) proprotein convertase subtilisin/kexin type 9,AI747682,Narc1...	Mouse	HEK293 Cells
	PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65.
TMPY-01565	PCSK9 Protein, Rat, Recombinant (His) proprotein convertase subtilisin/kexin type 9	Rat	HEK293 Cells
	PCSK9 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.8 kDa and the accession number is A6JYM6.
TMPY-00995	PCSK9 Protein, Rhesus, Recombinant (His) proprotein convertase subtilisin/kexin type 9	Rhesus	HEK293 Cells
	PCSK9 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.7 kDa and the accession number is A8T666.
TMPY-05199	PCSK9 Protein, Human, Recombinant (D374Y, mFc) PC9,proprotein convertase subtilisin/kexin type 9,FH3,NARC1,...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPK-00483	PCSK9 Protein, Cynomolgus, Recombinant (His) PCSK9	Cynomolgus	HEK293 Cells
	Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated.
TMPY-05218	PCSK9 Protein, Human, Recombinant (mFc) HCHOLA3,PC9,proprotein convertase subtilisin/kexin type 9,FH...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.4 kDa and the accession number is Q8NBP7-1.
TMPJ-00369	PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated Subtilisin/Kexin-Like Protease PC9,PCSK9,NARC1,Prop...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-8xHis-HA-Avi tag. The predicted molecular weight is 18 and 58-70 and 90-150 KDa and the accession number is Q8NBP7.
TMPJ-00443	PCSK9 Protein, Macaca nemestrina, Recombinant (His) Proprotein Convertase Subtilisin/Kexin Type 9,PCSK9...	Macaca nemestrina	HEK293 Cells
	Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.
TMPY-05114	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated LDLCQ1,NARC-1,PC9,FH3,NARC1,HCHOLA3,proprotein convertase su...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q8NBP7-1.

重组蛋白

Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, hFc)

Cat.No: TMPY-00722

Species: Human

Expression System: HEK293 Cells

Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, His)

Cat.No: TMPY-00723

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05131

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His)

Cat.No: TMPY-00408

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y, His)

Cat.No: TMPY-04966

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated

Cat.No: TMPY-05270

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPJ-00368

Species: Human

Expression System: HEK293 Cells

PCSK1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01635

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Mouse, Recombinant (mFc)

Cat.No: TMPY-05217

Species: Mouse

Expression System: HEK293 Cells

PCSK9 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01245

Species: Mouse

Expression System: HEK293 Cells

PCSK9 Protein, Rat, Recombinant (His)

Cat.No: TMPY-01565

Species: Rat

Expression System: HEK293 Cells

PCSK9 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-00995

Species: Rhesus

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y, mFc)

Cat.No: TMPY-05199

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00483

Species: Cynomolgus

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05218

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated

Cat.No: TMPJ-00369

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Macaca nemestrina, Recombinant (His)

Cat.No: TMPJ-00443

Species: Macaca nemestrina

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated

Cat.No: TMPY-05114

Species: Human

Expression System: HEK293 Cells

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