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Search Results for " pc9 "

Targets Recommended: Others

10

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12376	PC945 Opelconazole	Others	Others
	PC945 (Opelconazole) 是一种有效的广谱抗真菌化合物，对烟曲霉甾醇 14α-去甲基酶 (CYP51A/CYP51B) 有抑制作用，可用于研究肺部真菌感染。
T15650	KDM5A-IN-1	Histone Demethylase	Chromatin/Epigenetic
	KDM5A-IN-1 是一种可口服且具有高效性和选择性的泛组氨酸赖氨酸脱甲基酶 5 KDM5 抑制剂，抑制 KDM5A，KDM5B，KDM5C，IC50 值分别为 45 nM，56 nM 和 55 nM。KDM5A-IN-1 抑制 PC9 H3K4Me3，可用于研究癌症。
T1600	Doxifluridine Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine,去氧氟尿苷	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Doxifluridine (AMC 0101) 是一种胸苷磷酸化酶活化剂，对 PC9-DPE2细胞的 IC50为0.62 μM。它是具有抗肿瘤活性的抗肿瘤剂 5-fluorouracil (5-FU) 的氟嘧啶衍生物和口服前药。
T15649	KDM5-IN-1	Histone Demethylase	Chromatin/Epigenetic
	KDM5-IN-1 是一种有效的特异性 KDM5 抑制剂，IC50 为 15.1 nM。
T79394	ALK/EGFR-IN-3
	ALK/EGFR-IN-3 为ALK与EGFR的强效双重抑制剂，有效遏制H1975、PC9以及Baf3-EML4-ALK癌细胞系的生长，其IC50值分别为0.1360、0.0332及0.0339 μM。
T62060	NF-κB-IN-5
	NF-κB-IN-5 (化合物 4d) 是口服有效的靶向 NF-κB 抑制剂。NF-κB-IN-5 具有明显的抗肿瘤活性，抑制人癌细胞株，包括 HCT116、U87-MG、HepG2、BGC823、PC9，IC50分别为 5.35、2.81、2.83、2.02 和 3.90 μM。
T79393	ALK/EGFR-IN-2
	ALK/EGFR-IN-2 是一种高效的 ALK 和 EGFR 双重抑制剂，能够诱导癌细胞凋亡及 G0/G1 细胞周期停滞。此化合物在 H1975、PC9 和 Baf3-EML4-ALK 癌熙胞株的增殖抑制实验中，其 IC50 值分别为0.0034、0.0065 和 0.0018 μM，表明其对这些癌熙胞系具有显著的抑制作用。
T63492	BI-1622
	BI-1622 是具有高度选择性的、口服具有活力的 HER2(ERBB2) 抑制剂 (IC50: 7 nM)。BI-1622对EGFR 的选择性大于 25 倍。在转染 H2170 和 PC9 细胞的移植瘤小鼠模型中，BI-1622 表现出较高的体内的抗肿瘤作用，具有良好的药物代谢和药代动力学特性。
T61574	PD-L1-IN-1
	PD-L1-IN-1, a powerful PD-L1 inhibitor, demonstrated an IC50 of 115 nM. By forming a robust bond with the PD-L1 protein, PD-L1-IN-1 effectively suppressed tumor growth by enhancing the antitumor immune activity of peripheral blood mononuclear cells in co-cultures with PD-L1 expressing cancer cells (PC9 and HCC827 cells). It significantly elevated the release of interferon γ and induced apoptosis in cancer cells, while exhibiting minimal cytotoxicity in healthy cells [1].
T6734	WZ8040	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	WZ8040 是一种新型突变选择性不可逆 EGFRT790M 抑制剂，可抑制EGFR 磷酸化。它对突变型EGFR 的活性是野生型EGFR 的100倍以上。

化合物

Cat.No: T12376

Synonym: Opelconazole

Target: Others

Cat.No: T15650

Target: Histone Demethylase

Cat.No: T1600

Synonym: Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine,去氧氟尿苷

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T15649

Target: Histone Demethylase

Cat.No: T79394

Cat.No: T62060

Cat.No: T79393

Cat.No: T63492

Cat.No: T61574

Cat.No: T6734

Target: EGFR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05131	PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated NARC-1,PC9,LDLCQ1,NARC1,FH3,proprotein con...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 74.3 kDa and the accession number is Q8NBP7-1.
TMPY-00408	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) FH3,proprotein convertase subtilisin/kexin type 9,L...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is AAV67948.1.
TMPY-04966	PCSK9 Protein, Human, Recombinant (D374Y, His) LDLCQ1,NARC-1,PC9,NARC1,HCHOLA3,proprotein...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.5 kDa and the accession number is Q8NBP7-1.
TMPJ-00443	PCSK9 Protein, Macaca nemestrina, Recombinant (His) Proprotein Convertase Subtilisin/Kexin Type 9,P...	Macaca nemestrina	HEK293 Cells
	Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.
TMPJ-00368	PCSK9 Protein, Human, Recombinant (Avi), Biotinylated Subtilisin/Kexin-Like Protease PC9,PC<...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19&65 KDa and the accession number is Q8NBP7.
TMPJ-00369	PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated Subtilisin/Kexin-Like Protease PC9,PC<...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-8xHis-HA-Avi tag. The predicted molecular weight is 18 and 58-70 and 90-150 KDa and the accession number is Q8NBP7.
TMPY-05270	PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated FH3,NARC-1,PC9,LDLCQ1,proprotein convertas...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPY-05217	PCSK9 Protein, Mouse, Recombinant (mFc) HCHOLA3,Narc1,AI415265,AI747682,FH3,proprotein convertase su...	Mouse	HEK293 Cells
	PCSK9 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.6 kDa and the accession number is Q80W65.
TMPY-01245	PCSK9 Protein, Mouse, Recombinant (His) proprotein convertase subtilisin/kexin type 9,AI747...	Mouse	HEK293 Cells
	PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65.
TMPY-05199	PCSK9 Protein, Human, Recombinant (D374Y, mFc) PC9,proprotein convertase subtilisin/kexin...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPY-05218	PCSK9 Protein, Human, Recombinant (mFc) HCHOLA3,PC9,proprotein convertase subtilis...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.4 kDa and the accession number is Q8NBP7-1.
TMPY-05114	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated LDLCQ1,NARC-1,PC9,FH3,NARC1,HCHOLA3,propro...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q8NBP7-1.

重组蛋白

PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05131

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His)

Cat.No: TMPY-00408

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y, His)

Cat.No: TMPY-04966

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Macaca nemestrina, Recombinant (His)

Cat.No: TMPJ-00443

Species: Macaca nemestrina

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPJ-00368

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated

Cat.No: TMPJ-00369

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated

Cat.No: TMPY-05270

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Mouse, Recombinant (mFc)

Cat.No: TMPY-05217

Species: Mouse

Expression System: HEK293 Cells

PCSK9 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01245

Species: Mouse

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y, mFc)

Cat.No: TMPY-05199

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05218

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated

Cat.No: TMPY-05114

Species: Human

Expression System: HEK293 Cells

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