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Search Results for " neurokinin antagonist 1 "

44

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10056	Neurokinin antagonist 1	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Neurokinin antagonist 1是一种有效的是神经肽拮抗剂，可用于研究神经系统疾病。
T29157	WIN 51,708 WIN51,708,WIN-51,708
	WIN 51,708 is an antagonist of neurokinin-1 receptor.
T17156	Tradipitant VLY-686,LY686017	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Tradipitant (VLY-686) 是一种有效的神经激肽-1 拮抗剂。
T1743	Aprepitant MK-869,MK-0869,阿瑞匹坦,L-754030,Aprepitant`	HIV Protease; Antibacterial; Antibiotic; Neurokinin receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Aprepitant (Aprepitant`) 是选择性和高亲和力的神经激肽1受体拮抗剂，Kd 值为86 pM。
T13306L	Vapreotide acetate RC-160 acetate,醋酸伐普肽,BMY-41606 acetate	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Vapreotide acetate (BMY-41606 acetate) 是神经激肽-1 (NK1) 受体拮抗剂，IC50值为 330 nM。
T68068	Ezlopitant CJ 11974,CJ-11974,CJ11974	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Ezlopitant (CJ-11974) 是一种基于喹啉的原型 NK1受体拮抗剂 CP-96345的衍生物。
T6905	Netupitant Ro 67-31898/000,奈妥吡坦,CID 6451149	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Netupitant (CID 6451149) 是一种高效选择性、可口服的神经激肽 1 受体 (NK1) 拮抗剂，具有止吐作用，在 CHO 细胞中对 hNK1的 Ki 值为 0.95 nM。
T38144	Elinzanetant	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Elizanetant 是有效的神经激肽受体拮抗剂，在精神分裂症研究中有价值。
T25616	Lanepitant 2HCl LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Lanepitant 2HCl 是一种非肽类神经激肽-1 受体拮抗剂，具有镇痛和抗炎活性。Lanepitant 2HCl 抑制 P 物质与神经激肽-1 受体的结合，抑制神经源性炎症和疼痛传递，可用于研究偏头痛等疼痛性神经病变类疾病。
T25615	Lanepitant LY303870,LY-303870,LY 303870	Others	Others
	Lanepitant (LY303870) 是一种非肽类神经激肽-1（NK-1）拮抗剂,具有镇痛活性，可抑制神经源性硬脑膜炎症,可用于预防偏头痛。
T69140	Burapitant SSR 240600	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Burapitant（SSR 240600）是一种新型非肽速激肽神经激肽 1 （NK）受体拮抗剂，具有抗焦炉和抗抑郁活性。
T8235	L-732138	Neurokinin receptor	GPCR/G Protein; Neuroscience
	L-732138 是选择性有效和竞争性神经激肽-1受体拮抗剂，IC50为 2.3 nM，可减轻痛觉过敏并具有抗肿瘤作用。它在克隆的人 NK-1受体中的效力比在克隆大鼠 NK-1受体中高 200 倍，比人类 NK-2 和 NK-3 受体高 1000 倍以上。
T3724	Rolapitant hydrochloride Rolapitant HCl,罗拉匹坦盐酸盐	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Rolapitant (SCH619734) hydrochloride 是一种高效选择性和具有口服活性的神经激肽 1 (NK1) 受体拮抗剂，Ki 值为 0.66 nM。Rolapitant hydrochloride (Rolapitant HCl) 不与 CYP3A4 产生互作。Rolapitant hydrochloride 在雪貂呕吐模型中显示出强效的中枢介导的止吐活性。
T3716	Rolapitant 罗拉吡坦,SCH619734,罗拉匹坦	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂，Ki 值为0.66 nM。
T29210	ZD6021 ZD-6021,ZD 6021
	ZD6021 is an antagonist of neurokinin 1 receptor.
T24357	L 741671 L741671,L 741,671,L741,671,L-741,671,L-741671
	L 741671 is an antagonist of the neurokinin-1 receptor.
T70455	Nolpitantium besilate
	Nolpitantium besilate is a neurokinin-1 receptor antagonist.
T13306	Vapreotide BMY 41606,RC160	Others	Others
	Vapreotide is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).
T69720	CJ-17493 (free base)
	CJ-17493 (free base) is a Neurokinin-1 Receptor Antagonist.
T69184	Figopitant
	Figopitant is a tachykinin neurokinin-1 antagonist.
T68556	GW679769
	GW679769 is a neurokinin-1 receptor antagonist.
T10026	Tachykinin angatonist 1 Tachykinin antagonist 1	Others	Others
	Tachykinin antagonist 1 is an antagonist of neurokinin receptors.
T26169	S 16474 S16474,S-16474
	S 16474 is an antagonist of Neurokinin-1 Receptor.
T24359	L 743310 L-743310,L743310,L743,310,L 743,310,L-743,310
	L 743310 is an antagonist of the neurokinin-1 receptor.
T76635	(Trp7,β-Ala8)-Neurokinin A (4-10)
	(Trp7,β-Ala8)-Neurokinin A (4-10) 是一种有效的neurokinin-3 (NK3)拮抗剂。
T16406	Orvepitant maleate GW823296 maleate	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatmen
T70587	CJ-12255
	CJ-12255 is a Neurokinin-1 Receptor Antagonist.
T69721	CJ-17493 dihydrochloride
	CJ-17493 dihydrochloride is the salt form of CJ-17493, an isochroman neurokinin-1 receptor antagonist
TQ0087	NKP608	Neurokinin receptor	GPCR/G Protein; Neuroscience
	NKP608 is a selective and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50: 2.6 nM) and in vivo.
T10688	Casopitant mesylate GW679769B	P450; Neurokinin receptor	GPCR/G Protein; Metabolism; Neuroscience
	Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of antiemetics.
T76427	(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B
	(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B 是 Neurokinin B(Neurokinin Receptor) 的竞争性拮抗剂，pA2 为 5.5，对 Substance P 或 Neurokinin A 没有影响。
T73705	Imnopitant dihydrochloride
	Imnopitant dihydrochloride 是一种神经激肽NK1受体拮抗剂。
T4533	Serlopitant
	Serlopitant 是神经激肽-1 (NK-1)受体的选择性拮抗剂。
T25617	Lanepitant HCl trihydrate Lanepitant dihydrochloride trihydrate
	Lanepitant HCl trihydrate is an effective non-peptide neurokinin-1 receptor antagonist, suppresses neurogenic dural inflammation, and may have a role in migraine therapy.
T12210	Netupitant D6 CID-6451149 D6	Others	Others
	Netupitant D6 is the deuterium labeled Netupitant, which is a selective and orally active antagonist of neurokinin-1 receptor.
T76405	[D-Trp2,7,9] Substance P
	[D-Trp2,7,9] Substance P 是一种速激肽 (Neurokinin Receptor) 拮抗剂，对 NK-1、NK-2和 NK-3受体的 Ki 值分别为 1 μM、1.3 μM 和 ~9 μM。
T66676	SCH619734 SCH-619734
	Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity.
T76431	GR 83074
	GR 83074 是一种有效的选择性 NK-2(Neurokinin Receptor) 拮抗剂，pKB 为 8.23。GR 83074 对 NK-3 没有活性，并表现出 340 倍的 NK-2/NK-1 选择性。
T71935	WIN 66306
	WIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner.
T81077	Substance P(1-4)
	Substance P(1-4)为一有效的神经激肽受体(NK-R)拮抗剂，具有调节正常造血功能并抑制内源性红细胞集落(EEC)形成的能力。
T38276	Benzomalvin C
	Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.
T76406	[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)
	[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) 为高效的神经激肽 NK1 拮抗剂，能够有效抑制金蛋白 P 物质 (GPSP) 与 P 物质 (SP) 的活性。
T68371	Rolapitant hydrochloride hydrate
	Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of ...
T70456	Nolpitantium Free Base
	Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal species, including humans. In vitro, it was a potent antagonist in functional assays for NK1 receptors such as [Sar9, Met(O2)11]substance P-induced endothelium-dependent relaxation of rabbit pulmonary artery and contraction of guinea-pig ileum. Up to 1 mkM, Nolpitantium had no eff...

化合物

Neurokinin antagonist 1

Cat.No: T10056

Target: Neuropeptide Y Receptor

Cat.No: T29157

Synonym: WIN51,708,WIN-51,708

Cat.No: T17156

Synonym: VLY-686,LY686017

Target: Neurokinin receptor

Cat.No: T1743

Synonym: MK-869,MK-0869,阿瑞匹坦,L-754030,Aprepitant`

Target: HIV Protease, Antibacterial, Antibiotic, Neurokinin receptor

Vapreotide acetate

Cat.No: T13306L

Synonym: RC-160 acetate,醋酸伐普肽,BMY-41606 acetate

Target: Neurokinin receptor

Cat.No: T68068

Synonym: CJ 11974,CJ-11974,CJ11974

Target: Neurokinin receptor

Cat.No: T6905

Synonym: Ro 67-31898/000,奈妥吡坦,CID 6451149

Target: Neurokinin receptor

Cat.No: T38144

Target: Neurokinin receptor

Lanepitant 2HCl

Cat.No: T25616

Synonym: LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride

Target: Neurokinin receptor

Cat.No: T25615

Synonym: LY303870,LY-303870,LY 303870

Target: Others

Cat.No: T69140

Synonym: SSR 240600

Target: Neurokinin receptor

Cat.No: T8235

Target: Neurokinin receptor

Rolapitant hydrochloride

Cat.No: T3724

Synonym: Rolapitant HCl,罗拉匹坦盐酸盐

Target: Neurokinin receptor

Cat.No: T3716

Synonym: 罗拉吡坦,SCH619734,罗拉匹坦

Target: Neurokinin receptor

Cat.No: T29210

Synonym: ZD-6021,ZD 6021

Cat.No: T24357

Synonym: L741671,L 741,671,L741,671,L-741,671,L-741671

Nolpitantium besilate

Cat.No: T70455

Cat.No: T13306

Synonym: BMY 41606,RC160

Target: Others

CJ-17493 (free base)

Cat.No: T69720

Cat.No: T69184

Cat.No: T68556

Tachykinin angatonist 1

Cat.No: T10026

Synonym: Tachykinin antagonist 1

Target: Others

Cat.No: T26169

Synonym: S16474,S-16474

Cat.No: T24359

Synonym: L-743310,L743310,L743,310,L 743,310,L-743,310

(Trp7,β-Ala8)-Neurokinin A (4-10)

Cat.No: T76635

Orvepitant maleate

Cat.No: T16406

Synonym: GW823296 maleate

Target: Neurokinin receptor

Cat.No: T70587

CJ-17493 dihydrochloride

Cat.No: T69721

Cat.No: TQ0087

Target: Neurokinin receptor

Casopitant mesylate

Cat.No: T10688

Synonym: GW679769B

Target: P450, Neurokinin receptor

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B

Cat.No: T76427

Imnopitant dihydrochloride

Cat.No: T73705

Cat.No: T4533

Lanepitant HCl trihydrate

Cat.No: T25617

Synonym: Lanepitant dihydrochloride trihydrate

Cat.No: T12210

Synonym: CID-6451149 D6

Target: Others

[D-Trp2,7,9] Substance P

Cat.No: T76405

SCH619734 SCH-619734

Cat.No: T66676

Cat.No: T76431

Cat.No: T71935

Substance P(1-4)

Cat.No: T81077

Cat.No: T38276

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)

Cat.No: T76406

Rolapitant hydrochloride hydrate

Cat.No: T68371

Nolpitantium Free Base

Cat.No: T70456

Cat. No.	Product Name	Target	Signaling Pathways
T71833	Acetylaszonalenin
	Acetylaszonalenin is a fungal metabolite that has been found in A. flavipes.1 It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P with a Ki value of 170 μM.
T38033	Benzomalvin B
	Benzomalvin B is a fungal metabolite originally isolated from Penicillium. It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P by 24% in vitro when used at a concentration of 100 μg/ml.

天然产物

Acetylaszonalenin

Cat.No: T71833

Cat.No: T38033

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