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16

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8526	Metformin 甲福明,二甲双胍,1,1-Dimethylbiguanide	Mitophagy; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Metformin (1,1-Dimethylbiguanide) 是一种 AMPK 激活剂，具有血脑屏障渗透性。Metformin 可通过提高胰岛素敏感性和减少肠道对葡萄糖的吸收来改善血糖控制，常用于 2 型糖尿病的研究。
T0740	Metformin hydrochloride Metformin HCl,盐酸二甲双胍,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride	Mitophagy; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) 是一种抗糖尿病药物，抑制结肠、前列腺等多种 Y 细胞的增殖，具有作为抗 Y 药物的潜在功能。它可以透过血脑屏障，诱导自噬。
T32758	Linagliptin mixture with metformin Jentadueto Xr,Linagliptin / metformin,Jentadueto
	Linagliptin mixture with metformin is used for the treatment of type 2 diabetes.
T73712	Metformin-d6 hydrochloride 1,1-Dimethylbiguanide-d6 hydrochloride	AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) 是 Metformin 的一种氘代化物，可用于研究 Metformin 在体内的代谢，常作为Metformin的内标。
T70806	Metformin icosapent
	Metformin icosapent is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
T71222	Metformin glycinate
	Metformin glycinate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
T69405	Metformin embonate
	Metformin embonate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
T69049	Metformin orotate
	Metformin orotate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
T20028	Janumet Efficib,Janumet XR,Metformin / sitagliptin,Metformin hydrochloride mixture with sitagliptin phosphate
	Metformin hydrochloride mixture with sitagliptin phosphate is an AMP-activated protein kinase stimulant. It is also a CD26 antigen inhibitor, Gluconeogenesis inhibitor, and Glucose modulator.
T70804	Itasetron hydrochloride monohydrate
	Itasetron hydrochloride monohydrate is a potent 5HT-3 receptor antagonist.
T8929	BC1618 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-	Mitophagy; Others; E1/E2/E3 Enzyme; AMPK	Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling; Ubiquitination
	BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) 是一种具有口服活性的 Fbxo48 抑制剂，可刺激 Ampk 依赖性信号传导。它促进线粒体分裂，促进自噬并提高肝脏胰岛素敏感性。
T83971L	LCC-12 FA	Antiviral; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	LCC-12 FA 是一种由二甲双胍组成的二聚体，通过靶向线粒体铜（ii）从而诱导 NAD（H）池减少。LCC-12 FA 可减少细菌和病毒感染小鼠模型中的炎症，可用于研究代谢疾病。
T8532	IM156	OXPHOS	Apoptosis
	IM156 (HL156A; HL271 acetate) 是衍生自二甲双胍的化合物，是一种强效的，具有口服活性的AMPK 激活剂。IM156 在动物模型中可缓解与年龄相关的认知下降。IM156 是一种有效的氧化磷酸化 (OXPHOS) 抑制剂，可用于实体肿瘤的研究。
T0242	Sitagliptin 西他列汀,MK0431,西格列汀	Proteasome; DPP-4; Autophagy	Autophagy; Proteases/Proteasome; Ubiquitination
	Sitagliptin (MK0431) 是一种有效的 DPP4抑制剂，在 Caco-2 细胞中，IC50值为 19 nM。它是一种新型口服降糖药，可单独使用或与二甲双胍或噻唑烷二酮联合用于治疗 2 型糖尿病。
T11570	HL271	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.
T83866	LCC-12 formate
	LCC-12是一种铜(II)螯合剂，为二甲双胍的衍生物。作为单体，它能结合铜(II)并在20 µM的浓度下减少氢过氧化物依赖的NADH向NAD+的氧化。在10 µM的浓度下，LCC-12降低一次性人类细胞因子激活的单核衍生的巨噬细胞(MDMs)中IL-1β、IL-2、IL-6、IL-8和TNF-α的细胞因子水平，以及JAK2、STAT2和IL-1受体相关激酶4(IRAK4)的水平。此外，同样浓度的LCC-12减少了细胞因子激活的MDMs中CD80+和CD86+的数量。每日0.3 mg/kg的剂量可提高LPS或盲肠结扎穿孔模型小鼠的存活率。

化合物

Cat.No: T8526

Synonym: 甲福明,二甲双胍,1,1-Dimethylbiguanide

Target: Mitophagy, AMPK, Autophagy

Metformin hydrochloride

Cat.No: T0740

Synonym: Metformin HCl,盐酸二甲双胍,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride

Target: Mitophagy, AMPK, Autophagy

Linagliptin mixture with metformin

Cat.No: T32758

Synonym: Jentadueto Xr,Linagliptin / metformin,Jentadueto

Metformin-d6 hydrochloride

Cat.No: T73712

Synonym: 1,1-Dimethylbiguanide-d6 hydrochloride

Target: AMPK, Autophagy

Metformin icosapent

Cat.No: T70806

Metformin glycinate

Cat.No: T71222

Metformin embonate

Cat.No: T69405

Metformin orotate

Cat.No: T69049

Cat.No: T20028

Synonym: Efficib,Janumet XR,Metformin / sitagliptin,Metformin hydrochloride mixture with sitagliptin phosphate

Itasetron hydrochloride monohydrate

Cat.No: T70804

Cat.No: T8929

Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK

Cat.No: T83971L

Target: Antiviral, Antibacterial

Cat.No: T8532

Target: OXPHOS

Cat.No: T0242

Synonym: 西他列汀,MK0431,西格列汀

Target: Proteasome, DPP-4, Autophagy

Cat.No: T11570

Target: AMPK

Cat.No: T83866

Cat. No.	Product Name	Target	Signaling Pathways
TN2252	Syrosingopine	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Syrosingopine 是 MCT1和 MCT4双重抑制剂，对 MCT4 的效力高 60 倍，可防止乳酸和 H+ 流出。它是可口服抗高血压药物，联合二甲双胍具有研究癌症疾病的潜力。
T35532	Galegine hydrochloride
	Galegine hydrochloride, a guanidine derivative derived from G. officinalis, plays a role in inducing weight loss in mice and has contributed to the development of biguanides, including metformin and phenformin. This compound stimulates AMPK activation in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cell lines. Additionally, galegine hydrochloride exhibits antibacterial properties, particularly demonstrating a minimum inhibitory concentration of 4 mg/L against Staph...

天然产物

Cat.No: TN2252

Target: Dopamine Receptor

Galegine hydrochloride

Cat.No: T35532

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