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Cat. No.	Product Name	Target	Signaling Pathways
T9399	Menin-MLL inhibitor 20	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	Menin-MLL inhibitor 20 是一种不可逆的menin-MLL 相互作用抑制剂，具有抗肿瘤活性。
T2649	Menin-MLL inhibitor MI-2 Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	Menin-MLL inhibitor MI-2 (MI2) 抑制Menin-MLL 相互作用，IC50为 446±28 nM。
T2643	MI-3 Menin-MLL Inhibitor,Menin-MLL inhibitor 3,MI 3	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	MI-3 (Menin-MLL Inhibitor)是一种有高亲和力的 menin-MLL 抑制剂，IC50值为 648 nM，Kd 值为 201 nM。
T12002	Menin-MLL inhibitor 4	Others	Others
	Menin-MLL inhibitor 4 has antitumor activity.Menin-MLL inhibitor 4 is an inhibitor of Menin- MLL (mixed-lineage leukemia protein) interaction .
T12943	SNDX-5613	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	SNDX-5613 是一种 Menin-MLL 特异性抑制剂，Ki 为 0.149 nM，IC50 为 10 在 20 nM 之间，可用于 MLL 基因重排的急性白血病研究。
T13336	VTP50469	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	VTP50469 是一种高选择性和口服活性的Menin-MLL 相互作用抑制剂，具有有效的抗白血病活性，Ki 为 104 pM。
T78151	Bleximenib oxalate Menin-MLL inhibitor 24 oxalate	Epigenetic Reader Domain	Chromatin/Epigenetic
	Bleximenib (Menin-MLL inhibitor 24) oxalate 是一种用于癌症研究的menin-mixed-lineage leukemia 1（menin-MLL）抑制剂。
T28036	MI-2-2 MI22,MI 2 2	Histone Methyltransferase	Chromatin/Epigenetic
	MI-2-2 是一种抑制 menin 和 MLL 之间二价蛋白质-蛋白质相互作用的抑制剂，IC50 为 46 nM。 MI-2-2 与 menin 结合，Kd 为 22 nM。
T72360	Menin-MLL inhibitor 26
	Menin-MLL inhibitor 26 是一种 Menin-MLL 抑制剂。Menin-MLL inhibitor 26 也是一个活性参照物。 Menin-MLL inhibitor 26 可以抑制细胞生长。Menin-MLL inhibitor 26 可用于白血病的研究。
T79117	Menin-MLL inhibitor 27	Epigenetic Reader Domain	Chromatin/Epigenetic
	Menin-MLL inhibitor 27 是一种化合物，它能有效抑制Menin-MLL之间的相互作用，对于研究癌症具有潜在价值，尤其是在急性骨髓性白血病方面。
T79737	Menin-MLL inhibitor 29	Epigenetic Reader Domain	Chromatin/Epigenetic
	Menin-MLL inhibitor 29（Compound C1）是一种选择性Menin-MLLPPI抑制剂。该化合物与Menin紧密结合，具有138 nM的KD值，并以46 nM的IC50值明显抑制Menin与MBM1（Menin结合motif 1）的相互作用。在体外条件下，Menin-MLL inhibitor 29对HepG2和Hep3B肝癌细胞系表现出抑制增殖的作用（IC50s分别为0.31 μM和0.71 μM），也能有效抑制肿瘤生长。
T69628	Iptacopan hydrochloride hydrate
	Iptacopan hydrochloride hydrate is a highly potent and highly selective factor B inhibitor.
T72135	(1s,4s)-Menin-MLL inhibitor-23
	(1s,4s)-Menin-MLL inhibitor-23 是Menin-MLL inhibitor-23 的对应异构体。Menin-MLL inhibitor-23 (Example 99A) 是一种menin-MLL 相互作用抑制剂。
TQ0069	MI-503	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-503 是一种高效且可口服的 menin-mLL 相互作用抑制剂。
TQ0058	MI-463	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-463 是一种有口服活性的menin-mLL 相互作用的高效小分子抑制剂，IC50为15.3 nM。
T16072	MI-538	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-538是一种menin 和MLL 融合蛋白相互作用的抑制剂，IC50值为 21 nM。
T39585	Ziftomenib KO-539	Histone Methyltransferase	Chromatin/Epigenetic
	Ziftomenib (KO-539) 是一种具有抗肿瘤活性的 menin-MLL 相互作用抑制剂，可以用于研究白血病。
T11925	M‑89	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	M-89 可抑制 Menin-MLL 蛋白之间的相互作用，有研究混合谱系白血病的潜力。它是一种强特异性 menin 抑制剂，结合到 menin 的Kd 值为 1.4 nM。
T22978	MI-2 (hydrochloride)	Others	Others
	MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor (IC50: 446 ± 28 nM).
T39938	M-1211
	M 1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.
T15831	M-525	Others	Others
	M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL
T27134	DCYM21 DC YM 21,DC-YM21,DCYM-21,DC_YM21,DC YM21
	DCYM21 is an inhibitor of menin-MLL interaction. DCYM21 demonstrates potent and selective blockage of proliferation and induces both cell cycle arrest and differentiation of leukemia cells harboring MLL translocations.
T24472	MIV-6R MIV6R,VU05163101,VU0516310-1,VU0516310 1,MIV 6R
	MIV-6R is an inhibitor of the menin- MLL interaction that acts by demonstrating strong and selective effects in MLL leukemia cells and validating specific mechanisms of action.
T24484	ML399 VU-0516340,VU 0516340,ML-399,VU0516340,ML 399
	ML399 is the menin-- MLL interaction inhibitor that acts by demonstrating strong and selective effects in MLL leukemia cells and validating specific mechanism of action.
T13336L	VTP50469 fumarate	Others	Others
	VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.
T69629	M‑89 MLL inhibitor
	M‑89 is a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein−Protein Interaction (Kd = 1.4 nM; IC50 = 25nM). M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular menin protein at low nanomolar concentrations. M-89 inhibits cell growth in the MV4;11 and MOLM-13 leukemia cell lines carrying MLL fusion with IC50 values of 25 and 55 nM, respectively, and demonstrates >100-fold selectivity over the HL-60 leukemia cell line lacking MLL fusion.
T24463	MI-1481 MI 1481
	MI-1481 is an effective MML1 inhibitor (IC50: 3.6 nM). MI-1481 showed very potent inhibition of the menin-MLL1 interaction (IC50: 3.6 nM). MI-1481 also demonstrates pronounced activity in MLL leukemia cells and in vivo in MLL leukemia models.
T39937	M-808
	M-808 is a potent and efficacious covalent inhibitor, targeting the interaction between Menin and MLL. It demonstrates a high binding affinity with an IC50 value of 2.6 nM.

化合物

Menin-MLL inhibitor 20

Cat.No: T9399

Target: Epigenetic Reader Domain, Histone Methyltransferase

Menin-MLL inhibitor MI-2

Cat.No: T2649

Synonym: Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T2643

Synonym: Menin-MLL Inhibitor,Menin-MLL inhibitor 3,MI 3

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

Menin-MLL inhibitor 4

Cat.No: T12002

Target: Others

Cat.No: T12943

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T13336

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

Bleximenib oxalate

Cat.No: T78151

Synonym: Menin-MLL inhibitor 24 oxalate

Target: Epigenetic Reader Domain

Cat.No: T28036

Synonym: MI22,MI 2 2

Target: Histone Methyltransferase

Menin-MLL inhibitor 26

Cat.No: T72360

Menin-MLL inhibitor 27

Cat.No: T79117

Target: Epigenetic Reader Domain

Menin-MLL inhibitor 29

Cat.No: T79737

Target: Epigenetic Reader Domain

Iptacopan hydrochloride hydrate

Cat.No: T69628

(1s,4s)-Menin-MLL inhibitor-23

Cat.No: T72135

Cat.No: TQ0069

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: TQ0058

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T16072

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T39585

Synonym: KO-539

Target: Histone Methyltransferase

Cat.No: T11925

Target: Epigenetic Reader Domain, Histone Methyltransferase

MI-2 (hydrochloride)

Cat.No: T22978

Target: Others

Cat.No: T39938

Cat.No: T15831

Target: Others

Cat.No: T27134

Synonym: DC YM 21,DC-YM21,DCYM-21,DC_YM21,DC YM21

Cat.No: T24472

Synonym: MIV6R,VU05163101,VU0516310-1,VU0516310 1,MIV 6R

Cat.No: T24484

Synonym: VU-0516340,VU 0516340,ML-399,VU0516340,ML 399

VTP50469 fumarate

Cat.No: T13336L

Target: Others

M‑89 MLL inhibitor

Cat.No: T69629

Cat.No: T24463

Synonym: MI 1481

Cat.No: T39937

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