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27

抑制剂 & 化合物

4

天然产物

1

同位素

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Cat. No.	Product Name	Target	Signaling Pathways
T18202	m-PEG4-SH 2,5,8,11-四氧杂十三烷-13-硫醇	Others; PROTAC Linker	Others; PROTAC
	m-PEG4-SH 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T19906	5'-O-Tritylthymidine M-13,M13,M 13,Monotritylthymidine	Others	Others
	5'-O-Tritylthymidine is a blocker of the formation of the FAK/Mdm-2 complex. 5'-O-Tritylthymidine activates p53 and caspase-8. It also leads to increase detachment and apoptosis in breast and colon cancers.
T15870	m-PEG4-azide 13-Azido-2,5,8,11-tetraoxatridecane	Others	Others
	m-PEG4-azide, also referred to as 13-Azido-2,5,8,11-tetraoxatridecane, functions as a PEG-based PROTAC linker suitable for PROTACs synthesis[1].
T18145	m-PEG13-Boc	Others	Others
	m-PEG13-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18146	m-PEG13-Hydrazide	Others	Others
	m-PEG13-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T10157	Regorafénib N-oxyde (M2) 瑞戈非尼杂质 13	Raf; VEGFR; c-RET; PDGFR; c-Kit; Drug Metabolite	Angiogenesis; Apoptosis; MAPK; Metabolism; Tyrosine Kinase/Adaptors
	Regorafénib N-oxyde M2 是 Regorafenib 的活性代谢物。Regorafenib 是多靶点抑制剂，包括VEGFR1/2/3，PDGFRβ，Kit，RET 和 Raf-1 ， IC50分别是 13/4.2/46，22，7，1.5 和 2.5 nM。
T18147	m-PEG13-NHS ester	Others	Others
	m-PEG13-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T39693	Polyketide synthase 13-IN-3	Others	Others
	Polyketide synthase 13-IN-3 (compound 41) is a potent inhibitor of polyketide synthase 13, demonstrating a minimum inhibitory concentration (MIC) range of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv.
T71973	Gilteritinib hemifumarate ASP2215 hemifumarate	FLT; TAM Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Gilteritinib hemifumarate (ASP2215 hemifumarate) 是一种高效的 ATP 竞争性 FLT3（IC50 ： 0.29 nM）和 AXL（IC50： 0.73 nM）双重抑制剂，可用于治疗复发或难治性 FLT3 突变的 AML。
T62796	VEGFR-2-IN-13	Others	Others
	VEGFR-2-IN-13 (Compound 19a) 是一种有效的 VEGFR-2 抑制剂 (IC50: 3.4 nM)。VEGFR-2-IN-13 能够将 HepG2 的细胞周期停滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。
T79463	Antitumor agent-110	Apoptosis	Apoptosis
	Antitumor agent-110 (compound 13) 是一种抗癌咪唑四嗪，具备良好的渗透性，能够阻滞细胞周期于G2/M期并诱导apoptosis。
T63205	HSP90-IN-13	Others	Others
	HSP90-IN-13（compound 5k）是一种有效的HSP90抑制剂，具有25.07 nM的IC50值，并对EGFR、VEGFR-2以及Topoisomerase-2展现出多靶点作用。此外，HSP90-IN-13能够在G2/M期阻滞MCF-7细胞周期，并通过线粒体途径诱导细胞凋亡(apoptosis)。
T61101	FLT3-IN-13	Others	Others
	FLT3-IN-13 (compound 20) is a highly effective inhibitor targeting both topoisomerase II and FLT3 proteins in leukemic cells. It exhibits potent activity against these targets, with IC50 values of 2.26 μM for both. Moreover, FLT3-IN-13 induces cell cycle arrest at the G2/M phase and promotes apoptosis. Notably, it displays considerable anticytotoxic activity, specifically against leukemia [1].
T69629	M‑89 MLL inhibitor	Others	Others
	M‑89 is a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein−Protein Interaction (Kd = 1.4 nM; IC50 = 25nM). M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular menin protein at low nanomolar concentrations. M-89 inhibits cell growth in the MV4;11 and MOLM-13 leukemia cell lines carrying MLL fusion with IC50 values of 25 and 55 nM, respectively, and demonstrates >100-fold selectivity over the HL-60 leukemia cell line lacking MLL fusion.
TP1662	Galanin Receptor Ligand M35
	The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. The radiolabelled M35 and perf
T37674	Aspyrone	Others	Others
	Aspyrone is a polyketide fungal metabolite that has been found inAspergillusand has diverse biological activities.1,2It is active against a panel of 13 fungi when used at a concentration of 20 μg/ml and a panel of 21 bacteria in a disc assay when used at a concentration of 100 μg per disc.1Aspyrone (10-1,000 mg/L) is nematocidal againstP. penetrans.2 1.Torres, M., Balcells, M., Sala, N., et al.Bactericidal and fungicidal activity of Aspergillus ochraceus metabolites and some derivativesPestic. S...
T37140	5'-O-DMT-rI	Others	Others
	5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1]. [1]. Kadokura M. Synthesis of 4-thiouridine, 6-thioinosine, and 6-thioguanosine 3’,5’-O-bisphosphates as donor molecules for RNA ligation and their application to the synthesis of photoactivatable TMG-capped U1 snRNA fragments. J Org Chem. 2000 Aug 25;65(17):5104-13.
T37403	O-desmethyl Brinzolamide (hydrochloride)	Others	Others
	O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1,2It inhibits CAII and CAIV (IC50s = 0.136 and 165 nM, respectively).1 1.Huang, Q., Rui, E.Y., Cobbs, M., et al.Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressureJ. Med. Chem.58(6)2821-2833(2015) 2.Lo Faro, A.F., Tini, A., Gottardi, M., et al.Development and validation of a fast ultra-high-performance liquid chromatography tand...
T38382	8Br-HA	Others	Others
	8Br-HA is an inhibitor of fragile histidine triad diadenosine triphosphatase (FHIT; IC50= 0.12 μM).1It inhibits the growth of HCC827 and H460 lung cancer cells (GI50s = 0.87 and 5.9 μM, respectively). 1.Kawaguchi, M., Sekimoto, E., Ohta, Y., et al.Synthesis of fluorescent probes targeting tumor-suppressor protein FHIT and Identification of apoptosis-inducing FHIT inhibitorsJ. Med. Chem.64(13)9567-9576(2021)
T38021	Obafluorin	Others	Others
	Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens.1 It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 μg/ml for all). \|1. Pu, Y., Lowe, C., Sailer, M., et al. Synthesis, stability, and antimicrobial activity of (+)-obafluorin and related β-lactone antibiotics. J. Org. Chem. 59(13), 3642-3655 (1994).
T35817	Photoswitchable PAD Inhibitor (technical grade)	Others	Others
	Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 μM) and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro (kinact/KIs = 2,300, 600, 1,000, and 10,510 M-1min-1 for PAD1-4, respectively) and does not inhibit histone H3 citrullination in HEK29...
T36999	7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid	Others	Others
	Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to b...
T35814	Urocortin III (human) (trifluoroacetate salt)
	Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III , mouse urocortin II , human urocortin , and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively)....
T35406	α-MSH TFA
	α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo...
T35864	T-5342126	Others	Others
	T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-depen...
T35657	3'-Deoxyuridine-5'-triphosphate	Others	Others
	3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1]. 3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polymerases. 3'-Deoxyuridine-5'-tri...
T36176	AMK (hydrochloride)	Others	Others
	AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7...

化合物

Cat.No: T18202

Synonym: 2,5,8,11-四氧杂十三烷-13-硫醇

Target: Others, PROTAC Linker

5'-O-Tritylthymidine

Cat.No: T19906

Synonym: M-13,M13,M 13,Monotritylthymidine

Target: Others

Cat.No: T15870

Synonym: 13-Azido-2,5,8,11-tetraoxatridecane

Target: Others

Cat.No: T18145

Target: Others

m-PEG13-Hydrazide

Cat.No: T18146

Target: Others

Regorafénib N-oxyde (M2)

Cat.No: T10157

Synonym: 瑞戈非尼杂质 13

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Drug Metabolite

m-PEG13-NHS ester

Cat.No: T18147

Target: Others

Polyketide synthase 13-IN-3

Cat.No: T39693

Target: Others

Gilteritinib hemifumarate

Cat.No: T71973

Synonym: ASP2215 hemifumarate

Target: FLT, TAM Receptor

Cat.No: T62796

Target: Others

Antitumor agent-110

Cat.No: T79463

Target: Apoptosis

Cat.No: T63205

Target: Others

Cat.No: T61101

Target: Others

M‑89 MLL inhibitor

Cat.No: T69629

Target: Others

Galanin Receptor Ligand M35

Cat.No: TP1662

Cat.No: T37674

Target: Others

Cat.No: T37140

Target: Others

O-desmethyl Brinzolamide (hydrochloride)

Cat.No: T37403

Target: Others

Cat.No: T38382

Target: Others

Cat.No: T38021

Target: Others

Photoswitchable PAD Inhibitor (technical grade)

Cat.No: T35817

Target: Others

7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

Cat.No: T36999

Target: Others

Urocortin III (human) (trifluoroacetate salt)

Cat.No: T35814

Cat.No: T35406

Cat.No: T35864

Target: Others

3'-Deoxyuridine-5'-triphosphate

Cat.No: T35657

Target: Others

AMK (hydrochloride)

Cat.No: T36176

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T38295	Calpinactam	Others	Others
	Calpinactam is a fungal metabolite originally isolated from M. alpina that has antimycobacterial activity. It is active against M. smegmatis (MIC = 0.78 μg/ml) but not a panel of 13 other bacteria and fungi. Calpinactam increases survival in a silkworm model of M. smegmatis infection (ED50 = 5 μg/larva).
T38016	Hirsutide	Others	Others
	Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella. It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively). Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).
T37272	9(S),12(S),13(S)-TriHOME	Others	Others
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...
T35741	Gliovirin	Others	Others
	Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease...

天然产物

Cat.No: T38295

Target: Others

Cat.No: T38016

Target: Others

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

Target: Others

Cat.No: T35741

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T35790	Palmitic acid-1,2,3,4-13C4 Palmitic Acid-13C (C1, C2, C3, and C4 labeled)
	Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula...

同位素

Palmitic acid-1,2,3,4-13C4

Cat.No: T35790

Synonym: Palmitic Acid-13C (C1, C2, C3, and C4 labeled)

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