6
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37682 |
3-hydroxy Tridecanoic Acid
|
||
3-hydroxy Tridecanoic acid is a 13-carbon saturated fatty acid found in bacterial lipopolysaccharides (LPS). It can be used as an internal standard to detect markers of microorganisms in complex samples, including 3-hydroxy fatty acids found in LPS-containing bacteria and muramic acid found in bacterial cell wall peptidoglycan. | |||
T37677 |
3-hydroxy Docosanoic Acid
|
||
3-hydroxy Docosanoic acid is a hydroxylated form of the 22-carbon saturated docosanoic acid . It is found in lipopolysaccharides from C. trachomatis and C. psittaci and in S. synnaedendra. 3-hydroxy Docosanoic acid, in the form of an acyl-CoA metabolite, is an intermediate in fatty acid chain elongation from arachidic acid to docosanoic acid (C22:0). | |||
T38041 |
(R)-3-hydroxy Myristic Acid
|
||
Lipopolysaccharides (LPS) are components of the cell walls of Gram-negative bacteria. LPS is composed of polysaccharides and lipid A, where lipid A is a phosphoglycolipid containing acyl chains composed of 10 to 16 carbons. The lipid A component of LPS is detected by Toll-like receptor 4 of mammalian leukocytes and, thus, is a key determinant in immune response. (R)-3-Hydroxymyristic Acid is a form of the 14:0 lipid myristic acid that is found in the lipid A component of some Gram-negative bacte... | |||
T76273 |
Pep19-2.5
|
||
Pep19-2.5为合成抗毒素肽,能阻断内毒素信号级联。通过抑制跨膜及胞质模式识别受体(PRRs)介导的脂肽(LP)与脂多糖(LPS)的信号通路,Pep19-2.5关键调控与炎症及细胞焦亡(pyroptosis)相关的信号级联。 | |||
T78685 |
Polymyxin B
|
||
Polymyxin B是一种抗生素,它通过与细菌壁的LPS高亲和力结合,有效抑制革兰氏阴性菌感染,并能中和内毒素的效果。此外,Polymyxin B还能通过增加细菌细胞膜的渗透性来诱导细菌死亡。它也常用于内毒素血症研究。 | |||
T37679 |
3-hydroxy Palmitic Acid
|
||
3-hydroxy Palmitic acid is a form of the 16:0 lipid palmitic acid . The lipid A part of lipopolysaccharides contain various 3-hydroxy fatty acids, making oxylipins such as 3-hydroxy palmitic acid useful as chemical markers of endotoxins. In R. solanacearum, 3-hydroxy palmitic acid is converted by an S-adenosyl methionine-dependent methyltransferase to 3-hydroxy palmitic acid methyl ester, which acts as a quorum sensing signal molecule for post-transcriptional modulation of genes involved in viru... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11855 |
Lipopolysaccharides
脂多糖,LPS |
Others | Others |
Lipopolysaccharides (LPS) 属于天然产物,是一种来源于革兰氏阴性菌外膜外叶的内毒素。Lipopolysaccharides 是一种高免疫原性抗原,可以增强免疫反应,可以用于炎症模型构建。 | |||
T41078 |
Lipopolysaccharides, Escherichiacoli (11C)
LPS E. coli O55:B5,Lipopolysaccharide, E. coli O111:B4 |
Others | Others |
Lipopolysaccharides, Escherichiacoli (11C) (LPS E. coli O55:B5)是革兰阴性菌外膜的大分子成分,由脂质a、寡糖核心和o -特异性多糖(O-antigen) 3个区域组成。 | |||
T3826 |
Polygalasaponin F
异牡荆苷,瓜子金皂苷己 |
NF-κB; TLR; Akt; PI3K | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling |
Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷,可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌,能降低炎性细胞因子肿瘤坏死因子 α 的释放。 | |||
T3949 |
Myristic acid
肉豆蔻酸,Crodacid,Tetradecanoic acid,n-Tetradecanoic acid |
Others; Endogenous Metabolite | Metabolism; Others |
Myristic acid (Crodacid) 是饱和的 14 碳脂肪酸,存在于大多数动物、植物的脂肪中,特别是乳脂,椰子油,棕榈油和肉豆蔻油。 | |||
TQ0073 |
Andropanolide
|
HIV Protease; NO Synthase; Parasite | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Andropanolide 是一种来自穿心莲的二帖类化合物,具有抗HIV、抗疟和抗癌活性,对 Lipopolysaccharides (LPS) 刺激的 RAW264.7 巨噬细胞中一氧化氮 (NO) 的过量产生有抑制作用。 | |||
TN5090 |
Tachioside
|
Glucokinase | Metabolism |
Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows antiobesity activities. Tachioside can inhibit nitric oxide production in lipopolysaccharides-stimulated RAW 264.7 cells with IC50 value of 12.14 μM. |