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11

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39113L	Povorcitinib phosphate	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Povorcitinib phosphate 是一种选择性 JAK1 抑制剂，可用于治疗皮肤红斑狼疮和扁平苔藓的研究。
T2648	Pimecrolimus SDZ-ASM 981,ASM 981,吡美莫司	Others	Others
	Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体，能与胞质受体特异性的结合。
T75392	Lichenase
	Lichenase (endo-1,3:1,4-β-D-Glucanase) 是一种特异性内切-(1-3),(1-4)-β-D-葡聚糖 4-葡聚糖水解酶。Lichenase 溶解谷物中的 β-葡聚糖并产生低聚糖 (GOS)。Lichenase 可用于降解细胞壁中的多糖。
T83632	Usenamine A
	Usenamine A 是一种从地衣 Usnea longissima中提取到的小分子化合物，具有抗肿瘤活性，可用于研究肿瘤。
T17034	Temarotene Ro 15-0778	Others	Others
	Temarotene（Ro 15-0778）是一种具有口服活性和有效性的小分子化合物，可在体外调节人体免疫功能。Temarotene 可用于研究扁平苔藓。
T36409	Roccellic Acid
	Roccellic acid is a lichen secondary metabolite that has been found in R. montagnei and has antibacterial and anticancer activities.1,2 It is active against the bacteria S. gordonii and P. gingivalis (MIC = 46.9 μg/ml for both).1 Roccellic acid (100 μg/ml) inhibits proliferation of MDA-MB-231, MCF-7, and DLD-1 cancer cells by 65.3, 75.8, and 87.9%, respectively.2 \|1. Sweidan, A., Chollet-Krugler, M., Sauvager, A., et al. Antibacterial activities of natural lichen compounds against Streptococcus ...
T39113	Povorcitinib
	Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).
T37719	Galbinic Acid
	Galbinic acid is a depsidone lichen metabolite that has been found in U. undulata.1,2 It is active against the Gram-positive bacteria B. cereus, B. subtilis, and S. aureus, but not S. epidermidis (MICs = 62.5, 62.5, 250, and >250 μg/ml, respectively), as well as the Gram-negative bacterium E. coli, but not S. sonnei (MICs = 125 and >250 μg/ml, respectively).3 \|1. Salgado, F., Albornoz, L., Cortéz, C., et al. Secondary metabolite profiling of species of the genus Usnea by UHPLC-ESI-OT-MS-MS. Mole...
T35671	Salazinic Acid
	Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.1 It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM). Salazinic acid is cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 μM, respectively).2 It increases the wound closure rate in scratch-wounded HaCaT monolay...
T69014	Sekikaic Acid
	Sekikaic acid is a phenolic lichen metabolite that has been found in H. obscurata and has diverse biological activities. It scavenges superoxide and DPPH radicals in cell-free assays when used at a concentration of 0.5 µM. Sekikaic acid is active against the rg recombinant strain of respiratory syncytial virus (RSV; IC50 = 5.69 µg/ml). It inhibits the protein-protein interaction between mixed lineage leukemia 1 (MLL1) and the GACKIX domain of CREB-binding protein (CBP; IC50 = 34 µM).
T71811	Lobaric acid
	Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the h...

化合物

Povorcitinib phosphate

Cat.No: T39113L

Target: JAK

Cat.No: T2648

Synonym: SDZ-ASM 981,ASM 981,吡美莫司

Target: Others

Cat.No: T75392

Cat.No: T83632

Cat.No: T17034

Synonym: Ro 15-0778

Target: Others

Cat.No: T36409

Cat.No: T39113

Cat.No: T37719

Cat.No: T35671

Cat.No: T69014

Cat.No: T71811

Cat. No.	Product Name	Target	Signaling Pathways
T2839	Orsellinic acid	Others	Others
	Orsellinic acid 是一种利用Lecanoric acidy 用醇处理后得到的化合物。其中Lecanoric acid 是由 Parmotrema tinctorum 标本分离得到的地衣沉降物。
TN1413	Atranorin 荔枝素，巴美灵,荔枝素	Endogenous Metabolite; NO Synthase; Ras	GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism
	Atranorin 是地衣的次生代谢产物，具有显着的抗伤害、抗炎和氧化还原活性，对 H(2)O(2) 诱导的氧化应激下的细胞具有细胞保护作用。
T3982	Vulpinic Acid 狐衣酸,Vulpic acid,Pulvinic acid methyl ester	Others	Others
	Vulpinic Acid (Pulvinic acid methyl ester) 是地衣代谢物，可降低人脐静脉内皮细胞 (HUVEC) 中 H2O2诱导的ROS，氧化应激和氧化应激相关损伤，可作用于厌氧菌、葡萄球菌及肠球菌。它对脉粥样硬化的研究具有潜在的价值。
T6354	(+)-Usnic acid D-Usnic Acid,松萝酸,(+)-Usniacin,(+)-地衣酸	Antiviral; Antibacterial; mTOR	Immunology/Inflammation; Microbiology/Virology; PI3K/Akt/mTOR signaling
	(+)-Usnic acid (D-Usnic Acid) 是地衣中的二苯并呋喃衍生物，可结合 mTOR 的 ATP 结合口袋，抑制 mTORC1/2的活性。它诱导自噬，有抗菌和抗肿瘤活性。
T35673	Stictic Acid Scopularic acid	Others	Others
	Stictic Acid (Scopularic acid) 分离自苏门答腊地衣 Stereocaulon montagneanum，可抑制 HT-29 人结肠腺癌细胞的生长，IC50 为 29.29 μg/ml。
T3736	Olivetol 橄榄醇,5-Pentylresorcinol,5-n-Amylresorcinol,3,5-二羟基戊苯	Cannabinoid Receptor; P450; IκB/IKK	GPCR/G Protein; Metabolism; NF-κB
	Olivetol (5-n-Amylresorcinol) 是天然多酚类化合物，存在于地衣中，或由一些昆虫产生。它竞争性地抑制大麻素受体CB1和CB2，抑制 CYP2C19 (IC50=15.3 μM;Ki=7.21 μM) 和 CYP2D6 (IC50=2.71 μM;Ki=2.87 μM) 的活性。
TN4178	Gyrophoric acid	cAMP	GPCR/G Protein
	Vulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations, they can effectively prevent cytotoxic, apoptotic and cytoskeleton alterative activities of 2.5 J/cm(2) UVB in a dose-dependent manner, suggest that vulpinic and gyrophoric acids can be promising cosmetic ingredients to photo-protect human skin cells. Gyrophoric acid also has anti-proliferative/cytotoxic effect.
T75567	Cabenoside D
	Cabenoside D（化合物 8）是从苔藓根的甲醇提取物中分离的一种三萜苷，显示出对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的小鼠炎症的抗炎活性，并能抑制TPA促使的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）激活。

天然产物

Orsellinic acid

Cat.No: T2839

Target: Others

Cat.No: TN1413

Synonym: 荔枝素，巴美灵,荔枝素

Target: Endogenous Metabolite, NO Synthase, Ras

Cat.No: T3982

Synonym: 狐衣酸,Vulpic acid,Pulvinic acid methyl ester

Target: Others

Cat.No: T6354

Synonym: D-Usnic Acid,松萝酸,(+)-Usniacin,(+)-地衣酸

Target: Antiviral, Antibacterial, mTOR

Cat.No: T35673

Synonym: Scopularic acid

Target: Others

Cat.No: T3736

Synonym: 橄榄醇,5-Pentylresorcinol,5-n-Amylresorcinol,3,5-二羟基戊苯

Target: Cannabinoid Receptor, P450, IκB/IKK

Gyrophoric acid

Cat.No: TN4178

Target: cAMP

Cat.No: T75567

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