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Search Results for " loxin "

Targets Recommended: Apoptosis Topoisomerase

15

抑制剂 & 化合物

3

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T22456	Voreloxin hydrochloride SNS-595 hydrochloride,Vosaroxin,(3S-反式)-1,4-二氢-7-[3-甲氧基-4-(甲基氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸单盐酸盐	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	Voreloxin hydrochloride (SNS-595 hydrochloride) 是一种新型拓扑异构酶 II 抑制剂，能够诱导 DNA 双链断裂，阻滞 G2 期，引起细胞凋亡。
T63540	Astrophloxine	Beta Amyloid	Neuroscience
	Astrophloxine 是一种荧光成像探针，靶向反平行二聚体。Astrophloxine 能够用于检测阿尔茨海默症 (AD) 小鼠脑组织和脑脊液样本中聚集的 Aβ。
T40437L	Caloxin 2A1 acetate	Proton pump	Membrane transporter/Ion channel
	Caloxin 2A1 acetate 是细胞外质膜 Ca2+-ATPase (PMCA) 肽的抑制剂。 Caloxin 2A1 acetate 抑制 140-kDa 酸稳定酰基磷酸盐的 Ca2+ 依赖性形成。
T25969	Poloxin-2 Poloxin2,Poloxin 2	PLK	Cell Cycle/Checkpoint
	Poloxin-2 是一种具有有效性和选择性的 Plk1 PBD 抑制剂，具有抗肿瘤活性，可降低HeLa细胞中Plk1的蛋白水平。
T16703	Quarfloxin CX-3543	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Quarfloxin (CX-3543) 是一种氟喹诺酮衍生物，具有抗肿瘤活性，可靶向抑制RNA pol I 的活性，在神经母细胞瘤细胞中的 IC50 值在纳摩尔范围内。它破坏核糖体 DNA 模板中核仁蛋白和 G-四链体 DNA 结构之间的相互作用。
T16560	Poloxin	PLK	Cell Cycle/Checkpoint
	Poloxin 是一种 polo 样激酶 1 的 ATP 非竞争性抑制剂，靶向 polo-box 结构域，IC50值约为 4.8 μM。
T123923	Altiloxin B
	Altiloxin B 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T123923，CAS号为 92675-14-4。
T6724	Voreloxin Vosaroxin,AG 7352,SNS-595	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	Voreloxin (SNS-595) 是一种新型拓扑异构酶 II 抑制剂，具有广谱抗肿瘤活性。
T35923	Caloxin 2A1 TFA
	Caloxin 2A1 TFA is a peptide inhibitor specifically targeting the extracellular plasma membrane Ca2+-ATPase (PMCA), without influencing the basal activities of Mg2+-ATPase or Na+-K+-ATPase[1].
T34715	Stemphyloxin I Deacyl-FR 225654
	Stemphyloxin I is a phytotoxin from Stemphylium botryosum.
T37756	Phloxine B
	Phloxine B is a red dye, the USP grade of which is used as a color additive for food, drugs, and cosmetics. It has also been used as an alternative to Gram staining, to differentiate between Gram-negative and Gram-positive bacteria. At 100 μg/ml, it can inhibit methicillin-resistant S. aureus growth in vitro. Phloxine B has also been shown to modulate channel activity of wild-type cystic fibrosis transmembrane conductance regulator chloride channels (CFTR; Ki = 38 μM) and mutant delta F508 CFTR ...
T82789	Caloxin 1B1
	Caloxin 1B1是一种对PMCA4亲和力高的生物活性肽。该化合物是经由筛选与PMCA4胞外结构域1的结合而发现，能够特异性地在胞外环境中抑制PMCA。鉴于Caloxin 1B1被筛选用于与PMCA的细胞外结构域相结合，它可以被直接应用于细胞和组织中，用以评估其对平滑肌和内皮细胞功能的影响。
T40437	Caloxin 2A1
	Caloxin 2A1 is an inhibitor peptide of the plasma membrane Ca 2+-ATPase (PMCA) responsible for extracellular signaling. Importantly, Caloxin 2A1 has no impact on the basal Mg 2+-ATPase or Na+-K+-ATPase activities.
T40471	Azophloxine Acid red 1,Azophloxine
	Azophloxine, also known as acid red 1 (AR1), is a member of synthetic red azo dye family.
T80247	Caloxin 3A1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Caloxin 3A1是生物活性肽，属于caloxins系列，特指抑制外质膜(Plasma membrane, PM) Ca2+泵的化合物。具体作用通过抑制质膜钙泵(PMCA)并保持对肌浆网Ca2+泵无影响；同时，该肽不干预ATP合成酰基磷酸中间产物的形成。

化合物

Voreloxin hydrochloride

Cat.No: T22456

Synonym: SNS-595 hydrochloride,Vosaroxin,(3S-反式)-1,4-二氢-7-[3-甲氧基-4-(甲基氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸单盐酸盐

Target: Apoptosis, Topoisomerase

Cat.No: T63540

Target: Beta Amyloid

Caloxin 2A1 acetate

Cat.No: T40437L

Target: Proton pump

Cat.No: T25969

Synonym: Poloxin2,Poloxin 2

Target: PLK

Cat.No: T16703

Synonym: CX-3543

Target: DNA/RNA Synthesis

Cat.No: T16560

Target: PLK

Cat.No: T123923

Cat.No: T6724

Synonym: Vosaroxin,AG 7352,SNS-595

Target: Apoptosis, Topoisomerase

Caloxin 2A1 TFA

Cat.No: T35923

Cat.No: T34715

Synonym: Deacyl-FR 225654

Cat.No: T37756

Cat.No: T82789

Cat.No: T40437

Cat.No: T40471

Synonym: Acid red 1,Azophloxine

Cat.No: T80247

Target: Calcium Channel

Cat. No.	Product Name	Target	Signaling Pathways
TN2938	3-Hydroxy-3-acetonyloxindole	Others	Others
	3-Hydroxy-3-acetonyloxindole是一种天然产物，属于萝藦科牛奶菜属，其产品编号为 TN2938，CAS号为 33417-17-3。3-Hydroxy-3-acetonyloxindole可用作对照参考。
TN4752	Perilloxin	COX	Immunology/Inflammation; Neuroscience
	Perilloxin possesses inhibitory activities against cyclooxygenase-1,with IC(50) values of 23.2 microM.
TN3810	Dehydroperilloxin	COX	Immunology/Inflammation; Neuroscience
	Dehydroperilloxin possesses inhibitory activity against cyclooxygenase-1, with the IC(50) value of 30.4 microM.

天然产物

3-Hydroxy-3-acetonyloxindole

Cat.No: TN2938

Target: Others

Cat.No: TN4752

Target: COX

Dehydroperilloxin

Cat.No: TN3810

Target: COX

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02490	LOX-1 Protein, Human, Recombinant (His) LOXIN,SCARE1,SLOX1,LOX1,OLR1,oxidized low density l...	Human	HEK293 Cells
	LOX-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P78380.
TMPK-01168	LOX-1 Protein, Mouse, Recombinant (His) LOXIN,LOX-1,CLEC8A,Ox-LDL receptor 1,SLOX1,LOX1,SCA...	Mouse	HEK293 Cells
	LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis.

重组蛋白

LOX-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02490

Species: Human

Expression System: HEK293 Cells

LOX-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01168

Species: Mouse

Expression System: HEK293 Cells

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