Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Voreloxin (SNS-595) 是一种新型拓扑异构酶 II 抑制剂,具有广谱抗肿瘤活性。 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 Voreloxin hydrochloride 的水溶性和稳定性通常比游离态更好。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 857 | 35日内发货 | ||
5 mg | ¥ 2,730 | 35日内发货 | ||
25 mg | ¥ 9,870 | 35日内发货 |
Voreloxin 的其他形式现货产品:
产品描述 | Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2. |
体外活性 | Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. [1] Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. [2] Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. [3] Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%). [4] |
别名 | Vosaroxin, AG 7352, SNS-595 |
分子量 | 401.44 |
分子式 | C18H19N5O4S |
CAS No. | 175414-77-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (49.82 mM), Heating is recommended.
H2O: <1 mg/mL
Ethanol: <1 mg/mL
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.491 mL | 12.4552 mL | 24.9103 mL | 62.2758 mL |
5 mM | 0.4982 mL | 2.491 mL | 4.9821 mL | 12.4552 mL | |
10 mM | 0.2491 mL | 1.2455 mL | 2.491 mL | 6.2276 mL | |
20 mM | 0.1246 mL | 0.6228 mL | 1.2455 mL | 3.1138 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Voreloxin 175414-77-4 Apoptosis DNA Damage/DNA Repair Topoisomerase Vosaroxin SNS 595 inhibit AG-7352 Inhibitor AG 7352 SNS-595 SNS595 AG7352 inhibitor