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Search Results for " l-methionine "

20

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T41299	L-Methionine-DL-sulfoximine MSX,MSO	Others	Others
	L-Methionine-DL-sulfoximine (MSO) 抑制谷氨酰胺合成酶，主要在代谢和形态上影响星形胶质细胞。L-Methionine-DL-sulfoximine 可用于惊厥相关研究。
T32600	Lauroylmethionine N-Lauroyl-L-methionine,Lauroyl-L-methionine
	Lauroylmethionine is a lysine salt of the product formed by the condensation of lauroyl fatty acid chloride with methionine.
T34623	Serylmethionine Ser-met,L-Seryl-L-methionine
	Serylmethionine is a bioactive chemical.
T67544	N-Cbz-L-methionine
	N-Cbz-L-methionine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T67544。
T79929	L-Methionine γ-lyase Methionine lyase
	L-Methionine γ-lyase（Methionine lyase）是一种依赖磷酸吡哆醛的多功能酶，专门催化L-蛋氨酸（L-methionine）及其类似物的α, γ-裂解反应。该酶因其抗癌和抗感染活性被用于相关疾病的研究，同时也适用于同型半胱氨酸血症研究领域。
T79919	S-Adenosyl-L-methionine (1,4-butanedisulfonate) Ademetionine (1,4-butanedisulfonate),S-Adenosyl methionine (1,4-butanedisulfonate),AdoMet (1,4-butanedisulfonate)	Endogenous Metabolite	Metabolism
	S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate 作为一种口服活性的甲基供体，它是一种膳食补充剂，对抗抑郁和缓解疼痛具有显著功效。此化合物在癌症治疗中显示了抗增殖、促进凋亡和阻止转移的潜在作用。同时，S-Adenosyl-L-methionine 1,4-butanedisulfonate 也用于肝病和骨关节炎的相关研究。
T124334	S-Adenosyl-L-methionine tosylate
	S-Adenosyl-L-methionine tosylate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124334。
T124985	S-Adenosyl-L-Methionine iodide salt
	S-Adenosyl-L-Methionine iodide salt 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124985。
T67568	Fmoc-Met-OH Fmoc-L-Met-OH
	Fmoc-Met-OH (Fmoc-L-Met-OH) 是一种基于fmoc的程序合成的甲硫氨酸衍生物。
T67753	Trifluoromethyl-tubercidin	Influenza Virus	Microbiology/Virology
	Trifluoromethyl-tubercidin (TFMT)可抑制宿主Mtr1并抑制病毒复制。TFMT 通过其S-adenosyl-l-methionine 结合袋相互作用抑制Mtr1，限制流感病毒复制。TFMT 能有效抑制病毒在小鼠体内的复制，毒性很小。
T38943	L-Azidonorleucine hydrochloride
	L-Azidonorleucine hydrochloride, an unnatural amino acid, serves as a surrogate for Methionine. It is utilized for labeling mammalian cell proteins and identifying a broad range of methionyl-tRNA synthetase (MetRS) mutants.
T35767	SAHO2
	SAHO2is a sulfone form of the methyl donor S-(5'-adenosyl)-L-methionine chloride and is a substrate for radical SAM enzymes.1It is reductively cleaved to 5'-deoxyadenosine and 5'-thioadenosine sulfinic acid by the radical SAM enzymes NosL or NosN. 1.Mandalapu, D., Ji, X., and Zhang, Q.Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymesBiochemistry58(1)36-39(2019)
T38050	CP-609754	Transferase	Metabolism
	CP-609754 是高效的、可逆的法尼基转移酶抑制剂，对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng/mL 和 46 ng/mL。CP-609754有潜在的抗癌作用。
T41089	L-Homopropargylglycine hydrochloride
	L-Homopropargylglycine hydrochloride is an alkyl-based PROTAC linker used in PROTAC synthesis. It is an amino acid analog of methionine with an alkyne group, enabling a click chemical reaction with azide-containing Alexa Fluor.
T35766	SAHO
	SAHO is a sulfoxide form of the methyl donor S-(5'-adenosyl)-L-methionine chloride and a substrate for radical SAM enzymes.1It is reductively cleaved to S-adenosylhomocysteine , 5'-deoxyadenosine , and 5'-thioadenosine sulfenic acid by the radical SAM enzymes NosL or NosN. 1.Mandalapu, D., Ji, X., and Zhang, Q.Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymesBiochemistry58(1)36-39(2019)
T11500	GSK3368715 EPZ019997	Histone Methyltransferase	Chromatin/Epigenetic
	GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). It has strong anti-cancer activity.
T36869	5'-chloro-5'-Deoxyadenosine (hydrate)
	5'-chloro-5'-Deoxyadenosine (hydrate) is a nucleoside analog used as a substrate in polyketide biosynthesis. S-(5'-adenosyl)-L-methionine can be converted to 5'-chloro-5'-deoxyadenosine in a reaction catalyzed by a SAM-dependent chlorinase. Through a 7-step route, 5'-chloro-5'-deoxyadenosine can be converted to chloroethylmalonyl-CoA, which has been shown to be involved in the biosynthesis of the anticancer agent salinosporamide A in the marine bacterium S. tropica.
T78043	S-(2-Carboxyethyl)-L-cysteine S-Carboxyethylcysteine
	S-(2-Carboxyethyl)-L-cysteine（S-羧乙基半胱氨酸）为一非蛋白质(改性)硫氨基酸，在Acacia种子中被发现。该化合物能够影响大鼠对种子蛋白质的利用效率，并可能抑制由蛋氨酸诱发的大鼠生长速度，同时对大鼠血浆氨基酸水平产生不利影响。
T36802	Bisubstrate Inhibitor 78
	Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50= 1.41 μM).1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinamide . Bisubstrate inhibitor 78 is selective for NNMT over histone-lysine N-methytransferase NSD2 and protein arginine methyltransferase 1 (PRMT1; IC50s = >50 μM for both). It reduces levels of 1-methylnicotinamide in, and inhibits proliferation of, HSC-2 oral cancer cells when us...
T35816	ZLY032
	ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic st...

化合物

L-Methionine-DL-sulfoximine

Cat.No: T41299

Synonym: MSX,MSO

Target: Others

Lauroylmethionine

Cat.No: T32600

Synonym: N-Lauroyl-L-methionine,Lauroyl-L-methionine

Serylmethionine

Cat.No: T34623

Synonym: Ser-met,L-Seryl-L-methionine

N-Cbz-L-methionine

Cat.No: T67544

L-Methionine γ-lyase

Cat.No: T79929

Synonym: Methionine lyase

S-Adenosyl-L-methionine (1,4-butanedisulfonate)

Cat.No: T79919

Synonym: Ademetionine (1,4-butanedisulfonate),S-Adenosyl methionine (1,4-butanedisulfonate),AdoMet (1,4-butanedisulfonate)

Target: Endogenous Metabolite

S-Adenosyl-L-methionine tosylate

Cat.No: T124334

S-Adenosyl-L-Methionine iodide salt

Cat.No: T124985

Cat.No: T67568

Synonym: Fmoc-L-Met-OH

Trifluoromethyl-tubercidin

Cat.No: T67753

Target: Influenza Virus

L-Azidonorleucine hydrochloride

Cat.No: T38943

Cat.No: T35767

Cat.No: T38050

Target: Transferase

L-Homopropargylglycine hydrochloride

Cat.No: T41089

Cat.No: T35766

Cat.No: T11500

Synonym: EPZ019997

Target: Histone Methyltransferase

5'-chloro-5'-Deoxyadenosine (hydrate)

Cat.No: T36869

S-(2-Carboxyethyl)-L-cysteine

Cat.No: T78043

Synonym: S-Carboxyethylcysteine

Bisubstrate Inhibitor 78

Cat.No: T36802

Cat.No: T35816

Cat. No.	Product Name	Target	Signaling Pathways
T4844	L-Methionine L(-)-Methionin,L-蛋氨酸,L-Methionin	Endogenous Metabolite	Metabolism
	L-Methionine (L-Methionin) 是 Methionine 的 L-异构体。Methionine 是必需氨基酸，同时也是肝脏保护剂。
T19397	L-Methionine sulfoxide L-蛋氨酸亚砜,H-Met(O)-OH	Endogenous Metabolite	Metabolism
	L-Methionine sulfoxide (H-Met(O)-OH) 是一种甲硫氨酸的代谢产物，能够诱导 M1/classical 巨噬细胞极化，并调节氧化应激和嘌呤能的信号传递参数。
T4447	S-(5'-Adenosyl)-L-methionine tosylate S-腺苷蛋氨酸对甲苯磺酸盐,SAMe,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt	Others	Others
	S-(5'-Adenosyl)-L-methionine tosylate (SAMe) 是一种普遍存在的甲基供体，参与多种生物反应，包括由 DNA 和蛋白质甲基转移酶介导的反应。它可改善抑郁、与骨关节炎和纤维肌痛相关的疼痛以及肝毒性。
T8059	N-Acetyl-L-methionine N-Acetylmethionine,N-乙酰-L-蛋氨酸	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-methionine (N-Acetylmethionine) 是人体代谢物，在营养和代谢作用上和 L-methionine 相当。其中 L-methionine 是生长发育并不能够少的氨基酸。
T6752	S-Adenosyl-L-methionine disulfate tosylate S-腺苷蛋氨酸对甲苯磺酸硫酸盐,Ademetionine disulfate tosylate	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	S-Adenosyl-L-methionine disulfate tosylate (Ademetionine disulfate tosylate) 是一种主要生物甲基供体，在所有哺乳动物细胞中合成，但在肝脏中含量较高。
T5055	For-Met-OH fMet,N-甲酰甲硫氨酸,N-Formyl-L-methionine	Others; Endogenous Metabolite	Metabolism; Others
	For-Met-OH (N-Formyl-L-methionine) 是内源性代谢产物的一种。
T7475	S-Adenosyl-L-methionine AdoMet,Ademetionine,SAMe,S-Adenosyl methionine,S-腺苷-L-蛋氨酸	Others; Endogenous Metabolite	Metabolism; Others
	S-Adenosyl-L-methionine (Ademetionine) 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂，是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的口服具有活力的甲基供体，能够用于肝病和骨关节炎的研究。
TN6669	S-(5'-Adenosyl)-L-methionine chloride
	S-(5'-Adenosyl)-L-methionine chloride是一种天然产物，其产品编号为 TN6669，CAS号为 24346-00-7。S-(5'-Adenosyl)-L-methionine chloride可用作对照参考。
T4116	S-Adenosyl-DL-Methionine Ademetionine,S-腺苷蛋氨酸,S-ADENOSYL-L-METHIONINE	Others	Others
	S-Adenosyl-DL-Methionine (Ademetionine) 是一种 Ademetionine 的衍生物。其中Ademetionine 是蛋氨酸的中间代谢产物。
T74497	S-Adenosyl-L-methionine iodide
	S-(5'-Adenosyl)-L-methionine iodide (S-Adenosyl-L-methionine iodide) 是所有生物体中重要的甲基供体。
T4909	N-Acetyl-DL-methionine N-乙酰-DL-蛋氨酸,N-乙酰-DL-甲硫氨酸	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-DL-methionine 是内源性代谢产物的一种。
T6475	(±)-Carnitine chloride Monocamin,DL-Carnitine HCl,Bicarnesine,混旋肉碱盐酸盐,DL-Carnitine chloride	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	(±)-Carnitine chloride (Monocamin) 有D 和L 两种异构体。其中 L-carnitine 在脂肪酸的 β-氧化中起重要作用，也具有抗氧化作用和抗炎活性。
T2O2731	L-Aspartic acid L-天冬氨酸,L-天冬氨酸；L-天冬碱;L-酰胺天冬酸；L-天冬酰胺一水物,Aspatofort,Asparagic acid	Others; Endogenous Metabolite	Metabolism; Others
	L-Aspartic acid (Aspatofort) 是一种氨基酸，是结肠特异性药物输送的前体药物。
T8072	S-Methyl-L-cysteine S-甲基-L-半胱氨酸,S-Methylcysteine	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	S-Methyl-L-cysteine (S-Methylcysteine) 是一种催化抗氧化系统中甲硫氨酸硫氧化物还原酶 A 的作用底物，是一种天然产物，具有抗氧化、神经保护及减肥的功效。
T4877	L-Homocystine	Endogenous Metabolite	Metabolism
	L-Homocystine 是一种 L-homocysteine 的氧化物。其中 L-homocysteine 是抗血栓因子、血管舒张损害剂、促炎因子，也是研究心血管疾病发生机制的内质网应激反应的诱导剂。
TN2408	Evofolin B	Cannabinoid Receptor	GPCR/G Protein
	Evofolin B 是从Zanthoxylum ailanthoides 的茎皮中分离出来的天然化合物。Evofolin B 对人类中性粒细胞对甲酰-L-蛋氨酸-L-亮氨酸-L-苯丙氨酸/cytochalasin B（fMLP/CB）产生的超氧阴离子有抑制作用。
T5066	Nε,Nε,Nε-Trimethyllysine chloride Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) 是肠道菌群依赖性形成 N,N,N-trimethyl-5-aminovaleric acid (TMAVA) 的前体。

天然产物

Cat.No: T4844

Synonym: L(-)-Methionin,L-蛋氨酸,L-Methionin

Target: Endogenous Metabolite

L-Methionine sulfoxide

Cat.No: T19397

Synonym: L-蛋氨酸亚砜,H-Met(O)-OH

Target: Endogenous Metabolite

S-(5'-Adenosyl)-L-methionine tosylate

Cat.No: T4447

Synonym: S-腺苷蛋氨酸对甲苯磺酸盐,SAMe,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt

Target: Others

N-Acetyl-L-methionine

Cat.No: T8059

Synonym: N-Acetylmethionine,N-乙酰-L-蛋氨酸

Target: Others, Endogenous Metabolite

S-Adenosyl-L-methionine disulfate tosylate

Cat.No: T6752

Synonym: S-腺苷蛋氨酸对甲苯磺酸硫酸盐,Ademetionine disulfate tosylate

Target: DNA/RNA Synthesis

Cat.No: T5055

Synonym: fMet,N-甲酰甲硫氨酸,N-Formyl-L-methionine

Target: Others, Endogenous Metabolite

S-Adenosyl-L-methionine

Cat.No: T7475

Synonym: AdoMet,Ademetionine,SAMe,S-Adenosyl methionine,S-腺苷-L-蛋氨酸

Target: Others, Endogenous Metabolite

S-(5'-Adenosyl)-L-methionine chloride

Cat.No: TN6669

S-Adenosyl-DL-Methionine

Cat.No: T4116

Synonym: Ademetionine,S-腺苷蛋氨酸,S-ADENOSYL-L-METHIONINE

Target: Others

S-Adenosyl-L-methionine iodide

Cat.No: T74497

N-Acetyl-DL-methionine

Cat.No: T4909

Synonym: N-乙酰-DL-蛋氨酸,N-乙酰-DL-甲硫氨酸

Target: Others, Endogenous Metabolite

(±)-Carnitine chloride

Cat.No: T6475

Synonym: Monocamin,DL-Carnitine HCl,Bicarnesine,混旋肉碱盐酸盐,DL-Carnitine chloride

Target: Reactive Oxygen Species

L-Aspartic acid

Cat.No: T2O2731

Synonym: L-天冬氨酸,L-天冬氨酸；L-天冬碱;L-酰胺天冬酸；L-天冬酰胺一水物,Aspatofort,Asparagic acid

Target: Others, Endogenous Metabolite

S-Methyl-L-cysteine

Cat.No: T8072

Synonym: S-甲基-L-半胱氨酸,S-Methylcysteine

Target: Antioxidant, Reactive Oxygen Species

Cat.No: T4877

Target: Endogenous Metabolite

Cat.No: TN2408

Target: Cannabinoid Receptor

Nε,Nε,Nε-Trimethyllysine chloride

Cat.No: T5066

Synonym: Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride

Target: Others, Endogenous Metabolite

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