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Search Results for " hif-1alpha "

Targets Recommended: HIF

6

抑制剂 & 化合物

2

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36711	FM19G11 FM19G11,HIF-1alpha/2alpha Inhibitor	HIF	Angiogenesis; Chromatin/Epigenetic
	FM19G11 是一种低氧诱导因子 (HIF) α-亚基抑制剂（在低氧诱导的荧光素酶试验中 IC50 为 80 nM）。
T3494	LW6 HIF-1α inhibitor,CAY10585,LW8	Apoptosis; Dehydrogenase; HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Metabolism
	LW6 (HIF-1α inhibitor) 是一种新型 HIF-1抑制剂，IC50值为 4.4 μM。它降低 HIF-1α蛋白表达，但不影响 HIF-1β 表达。
T4381	Lificiguat 利非西呱,YC-1	Others; Guanylate cyclase; HIF	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Others
	Lificiguat (YC-1) 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶激活剂和低氧诱导因子 1α 的抑制剂。
T27028	CJ-3-60 CJ 3-60,CJ3-60,CJ-360,CJ360,CJ 360
	CJ-3-60, an anti-HIF-1alpha agent, inhibits HIF-1alpha and cellular VEGF proteins.
T28395	PG-928310
	PG-928310 has anti-HIF-1alpha activity.
T70903	KRH102053
	KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 and monocarboxylate transporter 4. Consistent with these results, KRH102053 also inhibited the rates of HIF-related migration and invasion of HOS cells as well as the degree of tube formation in human umbilical vein endothelium cells.

化合物

Cat.No: T36711

Synonym: FM19G11,HIF-1alpha/2alpha Inhibitor

Target: HIF

Cat.No: T3494

Synonym: HIF-1α inhibitor,CAY10585,LW8

Target: Apoptosis, Dehydrogenase, HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T4381

Synonym: 利非西呱,YC-1

Target: Others, Guanylate cyclase, HIF

Cat.No: T27028

Synonym: CJ 3-60,CJ3-60,CJ-360,CJ360,CJ 360

Cat.No: T28395

Cat.No: T70903

Cat. No.	Product Name	Target	Signaling Pathways
T21494	Oligomycin	HIF	Angiogenesis; Chromatin/Epigenetic
	Oligomycin 是一种抗真菌抗生素，是 H+-ATP 合成酶的抑制剂。Oligomycin 能够阻断氧化磷酸化和电子传递链。Oligomycin 对缺氧性肿瘤细胞 HIF-1alpha 表达具有抑制作用。
T6429	Caffeic Acid Phenethyl Ester Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE	Apoptosis; NF-κB	Apoptosis; NF-κB
	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) 是咖啡酸的苯乙醇酯，是蜂巢蜂胶的生物活性成分。它抑制核转录因子 NF-kappa B 的激活，具有抗肿瘤、细胞保护和免疫调节活性。它抑制 PDGF 诱导的血管平滑肌细胞增殖。

天然产物

Cat.No: T21494

Target: HIF

Caffeic Acid Phenethyl Ester

Cat.No: T6429

Synonym: Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE

Target: Apoptosis, NF-κB

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01709	HIF-1 alpha Protein, Human, Recombinant (His) bHLHe78,HIF-1 α,hypoxia inducible factor <...	Human	E. coli
	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has...
TMPY-04671	MCP-5 Protein, Mouse, Recombinant (His) chemokine (C-C motif) ligand 12,MCP-5,Scya1	Mouse	P. pastoris (Yeast)
	Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impaired fibronectin and collagen deposition and indirectly stimulated collagen degradation through upregulation of matrix metalloproteinase-2. In post-MI patients, circulating LPS levels strongly associated with the Ccl12 homologue monocyte chemotactic protein 1 (MCP-1). Both MCP-1 ...

重组蛋白

HIF-1 alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-01709

Species: Human

Expression System: E. coli

MCP-5 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04671

Species: Mouse

Expression System: P. pastoris (Yeast)

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