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Search Results for " hcv replication "

56

抑制剂 & 化合物

2

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Cat. No.	Product Name	Target	Signaling Pathways
T11539	HCV-IN-29	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	HCV-IN-29 是一种丙型肝炎病毒抑制剂。
T11541	HCV-IN-30	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	HCV-IN-30 是 HCV NS5A 复制复合物的抑制剂（基因型 1a 和 1b 复制子的 IC50 = 901 和 102 nM）。
T38237	2′-O-Methylcytidine	Nucleoside Antimetabolite/Analog; HCV Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	2'-O-Methylcytidine 是 2'-代核苷，可抑制 HCV 复制。它在体外抑制 NS5B 催化的 RNA 合成，其抑制方式是与底物核苷三磷酸竞争。
T9567	Samatasvir ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Samatasvir (ATOLIHZIXHZSBA-BTSKBWHGSA-N) 是 NS5A HCV 复制抑制剂。它能够有效的选择复制子及感染性 HCV，在基因型 1至5 复制子中，EC50= 2~24 pM。
T4686	Simeprevir TMC435,西咪匹韦,TMC-435350,Olysio	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Simeprevir (TMC435) 是一种有效的 HCV NS3/4A 蛋白酶抑制剂，抑制 HCV 复制，EC50 为 7.8 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T11281L	FGI-106 tetrahydrochloride	Virus Protease; HCV Protease; Influenza Virus; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	FGI-106 tetrahydrochloride 对多种病毒具有抑制活性，有抗埃博拉病毒，裂谷病毒和登革热病毒的 EC50分别为 100 nM，800 nM 和 400-900 nM，抑制非失血性发热病毒HCV 和HIV-1的EC50分别为 200 nM 和 150 nM 。
TQ0162	R-1479 4'-Azidocytidine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	R-1479 (4'-Azidocytidine) 是一种 RdRp 抑制剂，对于 HCV 亚基因组复制子系统中的 HCV RNA 复制，IC50 值为 1.28 μM。
T16088	MK-0608	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	MK-0608 是一种可口服的体外 HCV 复制抑制剂。在亚基因组复制子测定中，EC50值为 0.3 μM，EC90值为 1.3 μM。
T9331	Bemnifosbuvir hemisulfate AT-527	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Bemnifosbuvir hemisulfate (AT-527) 是一种 HCV 病毒复制抑制剂。
T3489	Dasabuvir ABT-333,达塞布韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Dasabuvir (ABT-333) 是丙型肝炎病毒非结构蛋白 5B 的非核苷抑制剂，是一种 RNA 依赖性 RNA 聚合酶，具有抗 HCV 的潜在活性。
T16710	Mericitabine R-7128,RG 7128,PSI 6130 diisobutyrate	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Mericitabine (R-7128) 是一种核苷HCV NS5B 聚合酶抑制剂。它充当 RNA 链终止子并防止 RNA 转录物在复制过程中延伸。
T1822L	Clemizole hydrochloride 克立咪唑盐酸,盐酸克立咪唑	HCV Protease; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Clemizole hydrochloride 是一种 TRPC5通道的抑制剂。它还是一种 H1 组胺受体拮抗剂，抑制 HCV 复制。
T12961	Sofosbuvir impurity F 索非布韦杂质 F,Sofosbuvir 3',5'-Bis-(S)-phosphate	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity F (Sofosbuvir 3',5'-Bis-(S)-phosphate) 既是 Sofosbuvir 的非对映异构体，也是 Sofosbuvir 的杂质，Sofosbuvir 是 HCV RNA 复制的抑制剂。
T9249	ITMN4077	Antiviral	Immunology/Inflammation
	ITMN4077 对感染人类 HuH7 细胞的丙型肝炎病毒具有抗病毒活性，评估为抑制 HCV 亚基因组复制子复制，EC50 为 2.131μM。
T1822	Clemizole 克立咪唑,吡咯咪唑	HCV Protease; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Clemizole 是一种 H1 组胺受体拮抗剂，可抑制 NS4B 的 RNA 结合和丙型肝炎病毒复制。它也是TRP5通道抑制剂。
T3226	Paritaprevir ABT-450,Veruprevir,帕利瑞韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Paritaprevir (ABT-450) 是一种口服生物可利用的合成酰基磺酰胺抑制剂，可抑制丙型肝炎病毒 (HCV) 蛋白酶复合物，由非结构蛋白 3 和 4A (NS3/NS4A) 组成，对 HCV 基因型 1 具有潜在活性。给药后，paritaprevir 可逆地结合 HCV NS3/NS4A 蛋白酶的活性中心和结合位点，并阻止 NS3/NS4A 蛋白酶介导的多蛋白成熟。这会破坏病毒蛋白的加工和病毒复制复合物的形成，从而抑制病毒在 HCV 基因型 1 感染的宿主细胞中的复制。 NS3 是一种丝氨酸蛋白酶，对于 HCV 多蛋白内多个位点的蛋白水解切割至关重要，并且在 HCV 核糖核酸 (RNA) 复制过程中起关键作用。 NS4A 是 NS3 的激活因子。 HCV 是属于黄病毒科的一种小的、有包膜的单链 RNA 病毒，感染与肝细胞癌 (HCC) 的发展有关。
T12962	Sofosbuvir impurity G	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity G 是 Sofosbuvir 的非对映异构体，是 Sofosbuvir 的杂质。其中 Sofosbuvir 能够抑制 HCVRNA 的复制，具有抗丙型肝炎病毒作用。
T4121	Bicyclol SY801,双环醇	HBV; Autophagy	Autophagy; Microbiology/Virology
	Bicyclol (SY801) 是一种抗肝炎 HBV 和 HCV 药物。
T19675	SM360320 CL-087,SM 360320,CL 087,1V136,SM-360320,CL087	TLR	Immunology/Inflammation
	SM360320 (CL-087) 是一种有效的特异性 TLR7 激动剂。 SM360320 除了其 IFN 介导的活性外，还通过 I 型 IFN 非依赖性机制抑制肝细胞中的 HCV 复制。 SM360320 可用于研究作为治疗性 DNA 疫苗的免疫佐剂。
T60531	2'-C-Methyladenosine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	2'-C-Methyladenosine 是丙型肝炎病毒(HCV)复制的抑制剂，分离自肾棒状杆菌。2'-C-Methyladenosine 抑制 HCV 复制子和 NS5B 催化的 RNA 合成，IC50值分别为 0.3 μM 和 1.9 μM。2'-C-Methyladenosine 还对Leishmania guyanensis (Lgy)和Leishmania braziliensis中的 LRV1有抑制作用。
T73253	EIDD-2749 4'-Fluorouridine,4'-FlU ; 4'-Fluorouridine,4'-FlU
	EIDD-2749 (4'-Fluorouridine) 是一种口服有效的RdRp 抑制剂。EIDD-2749 能有效抑制RSV 和SARS-CoV-2的复制。EIDD-2749 还表现出抗HCV 和淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 的活性。EIDD-2749 是一种很有潜力的COVID-19口服治疗候选剂，也适用于其他 RNA 病毒的研究。
T16774	RO-9187	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).
T19486	Nucleoside-Analog-2	Others	Others
	Nucleoside-Analog-2 is a 4'-Azidocytidine analogue, used to against Hepatitis C virus (HCV) replication.
T14289	Anguizole	Others	Others
	Anguizole, a small molecule, effectively inhibits Hepatitis C Virus (HCV) replication by modifying the subcellular distribution of NS4B. It demonstrates its potency with an IC50 value, highlighting its specific target action against HCV.
T27732	KIN1400
	KIN1400, a novel IRF3 activator, triggers IRF3-dependent innate immune antiviral genes and IFNbeta307 expression, suppresses WNV, DV infection, and HCV replication.
T14095	ACH-806 GS9132	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.
T12969	Sofosbuvir impurity N	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity N is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12965	Sofosbuvir impurity J	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12964	Sofosbuvir impurity I	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity I is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T71006	BI-1388
	BI-1388 is a highly potent inhibitor of HCV NS3 protease activity, inhibiting viral replication for various HCV genotypes and for resistant mutants D168V and R155K.
T12966	Sofosbuvir impurity K	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12957	Sofosbuvir impurity B	Others	Others
	Sofosbuvir impurity B is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay, with potent anti-hepatitis C virus (HCV) activity.
T12960	Sofosbuvir impurity E	Others	Others
	Sofosbuvir impurity E is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T79625	HCV-IN-43
	HCV-IN-43（化合物2）为HCVNS5B蛋白抑制剂，有效抑制丙型肝炎病毒（HCV）复制，适用于HCV感染研究。
T79626	HCV-IN-44
	HCV-IN-44（化合物28）为一种针对HCVNS5B蛋白的抑制剂，能够有效阻止丙型肝炎病毒（HCV）的复制。此化合物主要应用于HCV感染的相关研究。
T12968	Sofosbuvir impurity M	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity M is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12955	Sofosbuvir D6 PSI-7977 D6,GS-7977 D6	Others	Others
	Sofosbuvir D6 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
T70760	NVP018
	NVP018, also known as BC 556, is a potent inhibitor of hepatitis B virus, hepatitis C virus (HCV), and HIV-1 replication, shows minimal inhibition of major drug transporters, and has a high barrier to generation of both HCV and HIV-1 resistance..
T12959	Sofosbuvir impurity D	Others	Others
	Sofosbuvir impurity D is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T81694	NCI-B16
	NCI-B16为小分子RNA结合剂，具有抑制HCV病毒复制的功能。
T16715	Furaprofen 呋喃洛芬,R803	Others	Others
	Furaprofen is substantially more potent against genotype 1a and 1b replicons (EC50, ~30 nM) than against the genotype 2a replicon (EC50:1000 nM). Furaprofen is an effective HCV replication inhibitor.
T12954	Sofosbuvir 13CD3 GS-7977 13CD3,PSI-7977 13CD3	Others	Others
	Sofosbuvir 13CD3 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay, with potent anti-hepatitis C virus (HCV) activity.
T12958	Sofosbuvir impurity C	Others	Others
	Sofosbuvir impurity C is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T39347	RG-101
	RG-101 is a hepatocyte-targeted N-acetylgalactosamine conjugated oligonucleotide that functions as an antagonist for miR-122, an essential host factor in the replication of the hepatitis C virus (HCV).
T33432	MK-3281 MK 3281,MK3281
	MK-3281 is a potent, orally bioavailable hepatitis C virus NS5B polymerase finger-loop inhibitor. It is also an inhibitor of attractive molecular properties with good potency in HCV subgenomic replication trials and suitable for clinical candidates.
T71085	BMS-824
	BMS-824 is a potent NS5A inhibitor. The 50% inhibition of HCV replicon replication for BMS-824 was approximately 5 nM, with a therapeutic index of >10,000. BMS-824 showed good specificity for HCV, as it was not active against several other RNA and DNA viruses.
T12967	Sofosbuvir impurity L	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity L is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T69935	L0909
	L0909 is an orally available inhibitors of Hepatitis C virus with a novel mechanism of action (EC50 = 0.022 μM, SI > 600). L0909 could block HCV replication by acting on the HCV entry stage. The high sensitivity to clinical resistant HCV mutants and synergistic effect with clinical drugs were observed for this compound. L0909 as a promising HCV entry inhibitor for single or combinational therapeutic potential.
T12963	Sofosbuvir impurity H	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is a diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T74625	HCV-IN-41
	HCV-IN-41 (compound 4) 是一种高效的丙肝病毒 (HCV)抑制剂，对 HCV1b、2a、3a 和 4a 的 EC50分别为 0.006762 nM、5.183 nM、1.365 nM 和 142.2 nM。HCV-IN-41 能降低 HCVRNA 的复制。

化合物

Cat.No: T11539

Target: HCV Protease

Cat.No: T11541

Target: Others, HCV Protease

2′-O-Methylcytidine

Cat.No: T38237

Target: Nucleoside Antimetabolite/Analog, HCV Protease

Cat.No: T9567

Synonym: ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719

Target: HCV Protease

Cat.No: T4686

Synonym: TMC435,西咪匹韦,TMC-435350,Olysio

Target: HCV Protease, SARS-CoV

FGI-106 tetrahydrochloride

Cat.No: T11281L

Target: Virus Protease, HCV Protease, Influenza Virus, HIV Protease

Cat.No: TQ0162

Synonym: 4'-Azidocytidine

Target: HCV Protease

Cat.No: T16088

Target: HCV Protease

Bemnifosbuvir hemisulfate

Cat.No: T9331

Synonym: AT-527

Target: HCV Protease, SARS-CoV

Cat.No: T3489

Synonym: ABT-333,达塞布韦

Target: HCV Protease

Cat.No: T16710

Synonym: R-7128,RG 7128,PSI 6130 diisobutyrate

Target: HCV Protease

Clemizole hydrochloride

Cat.No: T1822L

Synonym: 克立咪唑盐酸,盐酸克立咪唑

Target: HCV Protease, Histamine Receptor

Sofosbuvir impurity F

Cat.No: T12961

Synonym: 索非布韦杂质 F,Sofosbuvir 3',5'-Bis-(S)-phosphate

Target: HCV Protease

Cat.No: T9249

Target: Antiviral

Cat.No: T1822

Synonym: 克立咪唑,吡咯咪唑

Target: HCV Protease, Histamine Receptor

Cat.No: T3226

Synonym: ABT-450,Veruprevir,帕利瑞韦

Target: HCV Protease

Sofosbuvir impurity G

Cat.No: T12962

Target: HCV Protease

Cat.No: T4121

Synonym: SY801,双环醇

Target: HBV, Autophagy

Cat.No: T19675

Synonym: CL-087,SM 360320,CL 087,1V136,SM-360320,CL087

Target: TLR

2'-C-Methyladenosine

Cat.No: T60531

Target: HCV Protease

Cat.No: T73253

Synonym: 4'-Fluorouridine,4'-FlU ; 4'-Fluorouridine,4'-FlU

Cat.No: T16774

Target: HCV Protease

Nucleoside-Analog-2

Cat.No: T19486

Target: Others

Cat.No: T14289

Target: Others

Cat.No: T27732

Cat.No: T14095

Synonym: GS9132

Target: HCV Protease

Sofosbuvir impurity N

Cat.No: T12969

Target: HCV Protease

Sofosbuvir impurity J

Cat.No: T12965

Target: HCV Protease

Sofosbuvir impurity I

Cat.No: T12964

Target: HCV Protease

Cat.No: T71006

Sofosbuvir impurity K

Cat.No: T12966

Target: HCV Protease

Sofosbuvir impurity B

Cat.No: T12957

Target: Others

Sofosbuvir impurity E

Cat.No: T12960

Target: Others

Cat.No: T79625

Cat.No: T79626

Sofosbuvir impurity M

Cat.No: T12968

Target: HCV Protease

Cat.No: T12955

Synonym: PSI-7977 D6,GS-7977 D6

Target: Others

Cat.No: T70760

Sofosbuvir impurity D

Cat.No: T12959

Target: Others

Cat.No: T81694

Cat.No: T16715

Synonym: 呋喃洛芬,R803

Target: Others

Sofosbuvir 13CD3

Cat.No: T12954

Synonym: GS-7977 13CD3,PSI-7977 13CD3

Target: Others

Sofosbuvir impurity C

Cat.No: T12958

Target: Others

Cat.No: T39347

Cat.No: T33432

Synonym: MK 3281,MK3281

Cat.No: T71085

Sofosbuvir impurity L

Cat.No: T12967

Target: HCV Protease

Cat.No: T69935

Sofosbuvir impurity H

Cat.No: T12963

Target: HCV Protease

Cat.No: T74625

Cat. No.	Product Name	Target	Signaling Pathways
T7607	PSI-6130 R 1656,2'-去氧-2'-氟-2'-C-甲基胞苷	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	PSI-6130 (R 1656) 是高效选择性 HCV NS5B 聚合酶抑制剂，抑制 HCV 复制，IC50值为 0.6 μM。
TN3809	Dehydrojuncusol	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is active against resistant HCV variants frequently found in patients with treatment failure.

天然产物

Cat.No: T7607

Synonym: R 1656,2'-去氧-2'-氟-2'-C-甲基胞苷

Target: HCV Protease

Dehydrojuncusol

Cat.No: TN3809

Target: HCV Protease

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