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Cat. No.	Product Name	Target	Signaling Pathways
TP1288	Fertirelin	Others	Others
	Fertirelin 是 GnRH 和 LH-RH 的类似物，可用于研究牛滤泡囊肿。它是促性腺激素释放激素激动剂。
T1494	Alarelin Acetate 阿拉瑞林,Alarelin	GNRH Receptor	GPCR/G Protein
	Alarelin Acetate 是一种合成的GnRH 激动剂。
T5520	Cetrorelix Acetate 醋酸西曲瑞克,Cetrorelix	GNRH Receptor	GPCR/G Protein
	Cetrorelix Acetate 是一种GnRH 受体的强效拮抗剂(IC50:1.21 nM)。
T27837	Linzagolix	GNRH Receptor	GPCR/G Protein
	Linzagolix 是一种口服有活性的非多肽GnRH 拮抗剂。可用于研究子宫肌瘤、子宫腺肌症、子宫内膜异位症。
T11174	(R)-Elagolix 恶拉戈利,NBI-56418	GNRH Receptor	GPCR/G Protein
	(R)-Elagolix (NBI-56418) 是口服具有活性的、选择性高的非肽类促性腺激素释放激素受体短期有效拮抗剂 (KD = 54 pM)。
T4102	Goserelin acetate 醋酸戈舍瑞林,Fertilan,ICI-118630 acetate,Zoladex	Apoptosis; GNRH Receptor	Apoptosis; GPCR/G Protein
	Goserelin acetate (Fertilan) 是一种促性腺激素释放激素 (GnRH/LHRH) 十肽类似物，能作为GnRH 激动剂。它可研究乳腺癌、上皮性卵巢癌和前列腺癌。
T5031	Elagolix sodium NBI-56418 sodium,恶拉戈利钠	GNRH Receptor	GPCR/G Protein
	Elagolix sodium (NBI-56418 sodium) 是人GnRH 受体拮抗剂，其IC50=0.25 nM，Ki=3.7 nM。
T10217L	Abarelix R3827,阿巴瑞克,PPI 149	GNRH Receptor	GPCR/G Protein
	Abarelix (PPI 149) 是一种促性腺激素释放激素 (GnRH) 拮抗剂，用于前列腺癌研究。
T3630	Relugolix RVT-601,瑞卢戈利,TAK-385	GNRH Receptor	GPCR/G Protein
	Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T5520L	Cetrorelix diacetate NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate	GNRH Receptor	GPCR/G Protein
	Cetrorelix diacetate (NS-75A) 是GnRH 受体的强效拮抗剂(IC50:1.21 nM)。
T21308	Histrelin Supprelin LA,组氨瑞林,Histrelin Acetate	Others	Others
	Histrelin (Supprelin LA) 是促性腺激素释放激素 (GnRH) 的九肽类似物，具有增加的效力。它被认为是 GnRH 激动剂。 Histrelin 用于治疗对激素敏感的男性前列腺癌和女性子宫肌瘤。
TP2337	Ganirelix Acetate	GNRH Receptor	GPCR/G Protein
	Ganirelix Acetate 是一种促性腺激素释放激素 (GnRH) 受体拮抗剂。
T10988L	Degarelix acetate(214766-78-6 free base)	GNRH Receptor	GPCR/G Protein
	Degarelix acetate(214766-78-6 free base) 是促性腺激素释放激素受体 (GnRHR) 的竞争性可逆拮抗剂。
TP1307	Buserelin Acetate (57982-77-1 free base) 布舍瑞林,Buserelin Acetate	GNRH Receptor	GPCR/G Protein
	Buserelin Acetate (57982-77-1 free base) (Buserelin Acetate) 是促性腺激素释放激素受体 (GnRHR) 的激动剂。
TP1896L1	Kisspeptin 234 acetate(1145998-81-7 free base)	GPR; Kisspeptin	Endocrinology/Hormones; GPCR/G Protein
	Kisspeptin 234 acetate(1145998-81-7 free base) 是Kisspeptin 受体 (KISS1, GPR54) 拮抗剂；是Kisspeptin-10 类似物。它抑制 Kisspeptin-10 对磷酸肌醇 (IP) (IC50 = 7 nM) 的刺激和促性腺激素释放激素 (GnRH) 的释放。
T23412	T 98475	Others	Others
	gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist,orally active
T17301	opigolix	Others	Others
	Opigolix is a Gonadotropin-releasing hormone receptor antagonist.
T10988	Degarelix	GNRH Receptor	GPCR/G Protein
	Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.
T10475	BAY-784	Others	Others
	BAY-784 is a gonadotropin-releasing hormone receptor (GnRH-R) antagonist (IC50s: 21 and 24 nM for human and rat GnRH-R).
T76351	[D-Ala6]-LH-RH
	[D-Ala6]-LH-RH，一种黄体激素释放激素(LHRH)模拟物，充当GnRH受体的激动剂。
TP1936	RFRP-3(human) RFRP 3 (human)
	Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
T76350	[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH
	[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH 是一种黄体激素释放激素 (LHRH) 类似物，可作为 GnRH 受体拮抗剂。
T28795	SKI2496 SKI 2496,SKI-2496
	SKI2496 is a potent and orally bioavailableantagonist of Gonadotropin-Releasing Hormone Receptor (hGnRHR IC50 = 0.46 nM; max. LH inh. inh. (%, h)= 84%, 12h; LH inh. (24h) = 76%.). SKI2496 exhibits more selective antagonistic activity toward the human GnRH
T70309	Dicetrorelix pamoate
	Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently lutein...
T76436	[MePhe7]-Neurokinin B
	[MePhe7]-Neurokinin B为NK-3受体(NK3R)激动剂，具有3 nM的IC50值。通过激活神经激肽3受体，[MePhe7]-Neurokinin B能够调节脉冲促性腺激素释放激素(GnRH)的分泌，成为调控该过程的潜在调节剂。
T68701	Abarelix acetate
	Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In vivo, abarelix decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.3 Abarelix (2 mg/kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseli...
T72990	BAY 1214784
	BAY 1214784是一种针对人促性腺激素释放激素受体(hGnRH-R)的高效、选择性口服活性拮抗剂，属于螺二氢吲哚衍生物化合物。该化合物能显著降低血浆促黄体激素水平，最高可达49%，同时显示出较低的药代动力学变异性和良好的耐受性，表现出研究子宫肌瘤的潜力。
T70775	Zoptarelin doxorubicin
	Zoptarelin doxorubicin, also known as AEZS-108, is an LHRH agonist. Zoptarelin doxorubicin is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R) that is conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates in...
T76047	TAK-683 TFA
	TAK-683 TFA是一种高效的全KISS1R激动剂(IC50=170 pM)，拥有较好的代谢稳定性，是九肽metastin的类似物，对KISS1R有激动效应，其对人和大鼠EC50值分别为0.96 nM和1.6 nM。TAK-683 TFA能够降低下丘脑GnRH水平，进而减少血浆FSH、LH、睾酮的浓度，显示出对激素依赖性前列腺癌研究的可能性。
T35794	Kisspeptin-54 (human) (trifluoroacetate salt)
	Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-5...
T81485	Phoenixin-14 TFA PNX-14 TFA
	Phoenixin-14 (PNX-14) TFA 是具抗焦虑、心脏保护及神经保护效果的穿透大脑屏障神经肽。它通过上调GnRH受体mRNA调控垂体促性腺激素分泌，并促进胰岛素释放。此外，Phoenixin-14 TFA保护小鼠免受缺血/再灌注(IR)伤害，通过降低ROS、提高GSH减缓氧化应激。

化合物

Cat.No: TP1288

Target: Others

Alarelin Acetate

Cat.No: T1494

Synonym: 阿拉瑞林,Alarelin

Target: GNRH Receptor

Cetrorelix Acetate

Cat.No: T5520

Synonym: 醋酸西曲瑞克,Cetrorelix

Target: GNRH Receptor

Cat.No: T27837

Target: GNRH Receptor

Cat.No: T11174

Synonym: 恶拉戈利,NBI-56418

Target: GNRH Receptor

Goserelin acetate

Cat.No: T4102

Synonym: 醋酸戈舍瑞林,Fertilan,ICI-118630 acetate,Zoladex

Target: Apoptosis, GNRH Receptor

Elagolix sodium

Cat.No: T5031

Synonym: NBI-56418 sodium,恶拉戈利钠

Target: GNRH Receptor

Cat.No: T10217L

Synonym: R3827,阿巴瑞克,PPI 149

Target: GNRH Receptor

Cat.No: T3630

Synonym: RVT-601,瑞卢戈利,TAK-385

Target: GNRH Receptor

Cetrorelix diacetate

Cat.No: T5520L

Synonym: NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate

Target: GNRH Receptor

Cat.No: T21308

Synonym: Supprelin LA,组氨瑞林,Histrelin Acetate

Target: Others

Ganirelix Acetate

Cat.No: TP2337

Target: GNRH Receptor

Degarelix acetate(214766-78-6 free base)

Cat.No: T10988L

Target: GNRH Receptor

Buserelin Acetate (57982-77-1 free base)

Cat.No: TP1307

Synonym: 布舍瑞林,Buserelin Acetate

Target: GNRH Receptor

Kisspeptin 234 acetate(1145998-81-7 free base)

Cat.No: TP1896L1

Target: GPR, Kisspeptin

Cat.No: T23412

Target: Others

Cat.No: T17301

Target: Others

Cat.No: T10988

Target: GNRH Receptor

Cat.No: T10475

Target: Others

Cat.No: T76351

Cat.No: TP1936

Synonym: RFRP 3 (human)

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH

Cat.No: T76350

Cat.No: T28795

Synonym: SKI 2496,SKI-2496

Dicetrorelix pamoate

Cat.No: T70309

[MePhe7]-Neurokinin B

Cat.No: T76436

Abarelix acetate

Cat.No: T68701

Cat.No: T72990

Zoptarelin doxorubicin

Cat.No: T70775

Cat.No: T76047

Kisspeptin-54 (human) (trifluoroacetate salt)

Cat.No: T35794

Phoenixin-14 TFA

Cat.No: T81485

Synonym: PNX-14 TFA

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