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Alarelin Acetate

Alarelin Acetate

产品编号 T1494   CAS 79561-22-1
别名: 阿拉瑞林, Alarelin

Alarelin Acetate 是一种合成的GnRH 激动剂。

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Alarelin Acetate Chemical Structure
Alarelin Acetate, CAS 79561-22-1
规格 价格/CNY 货期 数量
1 mg ¥ 175 现货
5 mg ¥ 447 现货
10 mg ¥ 747 现货
25 mg ¥ 915 现货
50 mg ¥ 1,080 现货
100 mg ¥ 1,590 现货
500 mg ¥ 3,930 现货
1 mL * 10 mM (in DMSO) ¥ 1,050 现货
产品目录号及名称: Alarelin Acetate (T1494)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Alarelin Acetate is a synthetic GnRH agonist which can directly inhibit proliferation and DNA synthesis of rat GSMC through GnRH receptors.
体外活性 The cell viability in the presence of alarelin was significantly lower compared to in the absence of alarelin. The maximum stimulatory effect on cell viability was achieved at a concentration of 10-5 M and it acted in a dose-dependent manner[1].
体内活性 Alarelin could inhibit the gastric acid secretion both by direct actions on parietal cells in rats and by inhibiting vagous function[2]. Alarelin could markedly increase the ratio of G1 phase and decrease ratio of S phase of GSMC of rats[1].
细胞实验 The cells are trypsinized in a solution of 2.5 g/L trypsin and seeded in a 96-well plate. After the cells are grown for 24 h to approximately 800 g/L subconfluent state, 0.1 mL medium containing 2.5% calf serum and various concentrations (0.001, 0.1, 10 μM) of alarelin is added to each well, respectively, and incubated for 24 h in a CO2 incubator. Each concentration is tested in at least 12 wells. Briefly, 15 μL of MTT solution is added to each well and incubated for 4 h. Then, the medium and MTT are removed and 150 μL of DMSO is added to each well and shaken for 10 min to dissolve the crystal. The OD is determined at 490 nm using an ELISA reader[1].
别名 阿拉瑞林, Alarelin
分子量 1167.34
分子式 C56H78N16O12
CAS No. 79561-22-1

存储

store at low temperture,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 58 mg/mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Chen L, et al. Expression of gonadotropin-releasing hormone receptor and effect of gonadotropin-releasing hormone analogue on proliferation of cultured gastric smooth muscle cells of rats. World J Gastroenterol. 2004 Jun 15;10(12):1780-4. 2. Chen L, et al. Distribution, cloning and sequencing of GnRH, its receptor, and effects of gastric acid secretion of GnRH analogue in gastric parietal cells of rats. Life Sci. 2005 Feb 4;76(12):1351-65.
AG 045572 LHRH (R)-Elagolix Cetrorelix diacetate Linzagolix Degarelix acetate(214766-78-6 free base) Ganirelix Acetate Buserelin Acetate (57982-77-1 free base)

相关化合物库

该产品包含在如下化合物库中:
抗癌药物库 多肽分子库 抗癌上市药物库 表型筛选靶点鉴定库 抗COVID-19化合物库 NO PAINS 化合物库 抗肥胖化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Alarelin Acetate 79561-22-1 GPCR/G Protein GNRH Receptor GnRH Receptor Inhibitor 阿拉瑞林 Gonadotropin releasing hormone receptor Alarelin inhibit GNRHR inhibitor

 

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