store at low temperture,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alarelin Acetate 是一种合成的GnRH 激动剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 175 | 现货 | ||
5 mg | ¥ 447 | 现货 | ||
10 mg | ¥ 747 | 现货 | ||
25 mg | ¥ 915 | 现货 | ||
50 mg | ¥ 1,080 | 现货 | ||
100 mg | ¥ 1,590 | 现货 | ||
500 mg | ¥ 3,930 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,050 | 现货 |
产品描述 | Alarelin Acetate is a synthetic GnRH agonist which can directly inhibit proliferation and DNA synthesis of rat GSMC through GnRH receptors. |
体外活性 | The cell viability in the presence of alarelin was significantly lower compared to in the absence of alarelin. The maximum stimulatory effect on cell viability was achieved at a concentration of 10-5 M and it acted in a dose-dependent manner[1]. |
体内活性 | Alarelin could inhibit the gastric acid secretion both by direct actions on parietal cells in rats and by inhibiting vagous function[2]. Alarelin could markedly increase the ratio of G1 phase and decrease ratio of S phase of GSMC of rats[1]. |
细胞实验 | The cells are trypsinized in a solution of 2.5 g/L trypsin and seeded in a 96-well plate. After the cells are grown for 24 h to approximately 800 g/L subconfluent state, 0.1 mL medium containing 2.5% calf serum and various concentrations (0.001, 0.1, 10 μM) of alarelin is added to each well, respectively, and incubated for 24 h in a CO2 incubator. Each concentration is tested in at least 12 wells. Briefly, 15 μL of MTT solution is added to each well and incubated for 4 h. Then, the medium and MTT are removed and 150 μL of DMSO is added to each well and shaken for 10 min to dissolve the crystal. The OD is determined at 490 nm using an ELISA reader[1]. |
别名 | 阿拉瑞林, Alarelin |
分子量 | 1167.34 |
分子式 | C56H78N16O12 |
CAS No. | 79561-22-1 |
store at low temperture,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 58 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Alarelin Acetate 79561-22-1 GPCR/G Protein GNRH Receptor GnRH Receptor Inhibitor 阿拉瑞林 Gonadotropin releasing hormone receptor Alarelin inhibit GNRHR inhibitor