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Search Results for " glucosamine "

15

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35418	β-D-Glucosamine Pentaacetate
	β-D-Glucosamine pentaacetate is an N-acetylglucosamine derivative that has been shown to promote hyaluronic acid production.
T37598	D-Glucosamine-6-sulfate
	D-Glucosamine-6-sulfate is a naturally occurring glycosaminoglycan. It activates the glmS ribozyme from B. subtilis, a Gram-positive bacterium, when used at a concentration of 200 μM. It has been used to form polyvalent dendrimer conjugates that inhibit angiogenesis and endothelial cell proliferation induced by FGF-2 in vitro and prevent scar tissue formation in a rabbit model of glaucoma surgery.
T37901	UDP-N-acetyl-D-Glucosamine (sodium salt hydrate)
	UDP-N-acetyl-D-Glucosamine is a natural nucleotide sugar that is used by glycosyltransferases to transfer N-acetyl-D-glucosamine residues to substrates.1It is an important component of antibiotic biosynthesis pathways in fungi and lipopolysaccharide production in bacteria.2,3 1.Roseman, S.Reflections on glycobiologyJ. Biol. Chem.276(45)41527-41542(2001) 2.Kudo, F., and Eguchi, T.Biosynthetic genes for aminoglycoside antibioticsJ. Antibiot. (Tokyo)62(9)471-481(2009) 3.Mulrooney, E.F., Poon, K.K.,...
T74160	UDP-glucosamine disodium
	UDP-glucosamine (UDP-GlcNAc) disodium 是一种化合物，作为O-GlcNAc转移酶的底物，负责催化O-GlcNAc与蛋白质的结合。同时，O-GlcNAc酶则负责催化从蛋白质中移除O-GlcNAc。作为己糖胺生物合成途径的终产物，UDP-glucosamine (UDP-GlcNAc) disodium主要受葡萄糖-6-磷酸-谷氨酰胺:果糖-6-磷酸氨基转移酶(GFAT)的调节。
T20949	NAGKi NAGK-i,NAGK i,3-O-Methyl-N-acetyl-D-glucosamine
	NAGKi is an inhibitor of N-acetylmannosamine kinase (NAMK) and N-acetylglucosamine kinase (NAGK).
T74549	N-Acetyl-α-D-glucosamine 1-phosphate disodium
	N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P) 为异位糖磷酸盐，关键中间体于N-糖蛋白生物合成。该化合物同时作为细菌细胞壁组分磷胆酸和鼠胺的代谢前体。
T78352	N-acetylglucosamine-1-P uridyltransferase (AGX1) GlcNAc1pUT
	N-acetylglucosamine-1-P uridyltransferase (AGX1) (GlcNAc1pUT) 是具有双功能乙酰转移酶/尿苷转移酶活性的原核生物专有酶。该酶能结合GlcNAc-1-P与UTP，催化合成UDP-GlcNAc的尿苷酰转移反应。
T10789	Chitosan oligosaccharide COS,壳聚糖低聚乳酸酯	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Chitosan oligosaccharide (COS) 是 β-(1→4)-连接的 D-氨基葡萄糖的寡聚体，Chitosan oligosaccharide可激活 AMPK ，抑制NF-κB 和 MAPK在内的炎症信号通路。
T27344	FMDP
	FMDP is a glucosamine-6-phosphate synthase inhibitor.
T71535	GlmU-IN-5175178
	GlmU-IN-5175178 is an inhibitor of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU).
T37276	2,5-Deoxyfructosazine (hydrochloride)
	2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL...
T76132	β-N-Acetylhexosaminidase
	β-N-Acetylhexosaminidase 是一种外切糖苷酶，可催化寡糖中末端非还原性 β-N-乙酰半乳糖胺和葡糖胺残基的水解，可用于表观遗传应用。
T61784	GlcN-6-P Synthase-IN-1
	GlcN-6-P Synthase-IN-1 (Compound 4d) is a potent inhibitor of Glucosamine-6-phosphate (GlcN-6-P) synthase, with an IC50 of 3.47 μM. This compound demonstrates remarkable antimicrobial activity and exhibits excellent penetration in the central nervous system. Additionally, GlcN-6-P Synthase-IN-1 is capable of inhibiting cytochrome P450, specifically the CYP3A4 isoform [1].
T37850	Chitobiose Octaacetate
	Chitobiose is a dimer of β-1,4 linked glucosamine units derived from chitin, which, in turn, is a long chain polymer of N-acetylglucosamine that is a primary component of fungal cell walls and arthropod exoskeletons. Chitobiose octaacetate is a form of chitobiose containing eight acetate groups. It is formed by the acetolysis of chitin. Chitobiose octaacetate can be used for the synthesis of chitobiose oxazoline and other chitin precursors.
T71525	AB05831
	AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis of terminal, non-reducing N-acetyl-\|3-D-glucosamine (GlcNAc) andN-acetyl-(3-D-galactosamine (GalNAc) residues in glycoproteins, gan-gliosides, and glycosaminoglycans (GAGs). HEX, released by chondrocytes into the extracellular compartment, promotes cartilage matrix degradation. ...

化合物

β-D-Glucosamine Pentaacetate

Cat.No: T35418

D-Glucosamine-6-sulfate

Cat.No: T37598

UDP-N-acetyl-D-Glucosamine (sodium salt hydrate)

Cat.No: T37901

UDP-glucosamine disodium

Cat.No: T74160

Cat.No: T20949

Synonym: NAGK-i,NAGK i,3-O-Methyl-N-acetyl-D-glucosamine

N-Acetyl-α-D-glucosamine 1-phosphate disodium

Cat.No: T74549

N-acetylglucosamine-1-P uridyltransferase (AGX1)

Cat.No: T78352

Synonym: GlcNAc1pUT

Chitosan oligosaccharide

Cat.No: T10789

Synonym: COS,壳聚糖低聚乳酸酯

Target: AMPK

Cat.No: T27344

GlmU-IN-5175178

Cat.No: T71535

2,5-Deoxyfructosazine (hydrochloride)

Cat.No: T37276

β-N-Acetylhexosaminidase

Cat.No: T76132

GlcN-6-P Synthase-IN-1

Cat.No: T61784

Chitobiose Octaacetate

Cat.No: T37850

Cat.No: T71525

Cat. No.	Product Name	Target	Signaling Pathways
T0429	Glucosamine Chitosamine,D-Glucosamine,氨基葡萄糖,葡糖胺	MMP; Others; TNF; NF-κB; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; CFTR; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Others; Proteases/Proteasome
	Glucosamine (Chitosamine) 是软骨基质和滑液中糖胺聚糖的天然成分，常用作骨关节炎的治疗方法。它也是一种氨基糖，是糖基化蛋白和脂质生化合成的突出前体，用作膳食补充剂。
T2792	Glucosamine sulfate 硫酸葡萄糖胺,硫酸氨基葡萄糖,D-Glucosamine sulphate,D-Glucosaminesulfate	MMP; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; Autophagy	Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Glucosamine sulfate (D-Glucosaminesulfate) 是软骨基质和滑液中糖胺聚糖的天然成分，常用作骨关节炎的治疗方法。它也是一种氨基糖，是糖基化蛋白和脂质生化合成的突出前体，用作膳食补充剂。
T2941	Glucosamine hydrochloride Chitosamine hydrochloride,盐酸氨基葡萄糖,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride	Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; Autophagy	Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB
	Glucosamine hydrochloride (Chitosamine hydrochloride) 是软骨基质和滑液中糖胺聚糖的天然成分，常用作骨关节炎的治疗方法。它也是一种氨基糖，是糖基化蛋白和脂质生化合成的突出前体，用作膳食补充剂。
T4514	N-Acetyl-D-Glucosamine N-乙酰-D-氨基葡萄糖,NAG,N-Acetyl-2-amino-2-deoxyglucose,Marine Sweet,N-Acetyl-2-amino-2-deoxy-D-glucose,N-乙酰氨基葡萄糖,GlcNAc	Endogenous Metabolite	Metabolism
	N-Acetyl-D-Glucosamine (NAG) 是葡萄糖的单糖衍生物。
T78485	D-Glucosamine 6-phosphate Glucosamine-6-phosphate	Endogenous Metabolite	Metabolism
	D-Glucosamine 6-phosphate为内源性代谢分子，谷氨酰胺果糖-6-磷酸氨基转移酶(GFAT)介导合成。该化合物常用于糖尿病研究领域。
T1715	Chitosan (MW 150000) 壳聚糖,Chitosan,Poly(D-glucosamine),Deacetylated chitin	Antibacterial; Antifungal	Microbiology/Virology
	Chitosan (MW 150000) (Deacetylated chitin) 是衍生自几丁质的聚阳离子线性多糖。它无毒，具有低致敏性，生物相容性和可生物降解性。它还具有抗肿瘤，抗细菌，抗真菌和抗氧化活性。
T3244	2-Deoxy-2-sulfoamino-D-glucose sodium 氨基葡萄糖硫酸钠盐,N-Sulfo-D-glucosamine sodium salt,N-Sulfo-glucosamine sodium salt,GlcN-2S,2-Deoxy-2-sulfamino-D-glucopyranose	Others; Endogenous Metabolite	Metabolism; Others
	2-Deoxy-2-sulfoamino-D-glucose sodium (GlcN-2S) 是内源性代谢产物的一种。
TL0006	Cichoric Acid 菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid	Reactive Oxygen Species; HIV Protease	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Cichoric Acid (Dicaffeoyltartaric acid) 是一种天然化合物，具有抗氧化作用。
T3762	Hyaluronic acid 透明质酸,Hyaluronate,玻尿酸,hyaluronan	Others; Endogenous Metabolite	Metabolism; Others
	Hyaluronic acid (hyaluronan) 由玉米发酵得到，是由二糖的重复单元组成的生物聚合物，应用领域广泛。
T38541	Chitobiose dihydrochloride
	Chitobiose dihydrochloride is a chitosan oligosaccharide consisting of β-1,4-linked glucosamine units.
TN4441	Linderaspirone A	Others	Others
	Linderaspirone A shows significant activity against glucosamine-inducedinsulin resistance.
TN3511	Bi-linderone	Others	Others
	Bi-linderone shows significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 microg/mL.
T40436	N,N'-Diacetylchitobiose
	N,N'-Diacetylchitobiose, a dimer of β(1,4) linked N-acetyl-D glucosamine, is derived from the hydrolysis of chitin. This compound serves as an alternative carbon source for E. coli.
T82737	Chitobiose
	Chitobiose为壳寡糖，为β-1,4-氨基葡萄糖二聚体，具备口服活性及较高的抗氧化活性。

天然产物

Cat.No: T0429

Synonym: Chitosamine,D-Glucosamine,氨基葡萄糖,葡糖胺

Target: MMP, Others, TNF, NF-κB, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, CFTR, Autophagy

Glucosamine sulfate

Cat.No: T2792

Synonym: 硫酸葡萄糖胺,硫酸氨基葡萄糖,D-Glucosamine sulphate,D-Glucosaminesulfate

Target: MMP, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy

Glucosamine hydrochloride

Cat.No: T2941

Synonym: Chitosamine hydrochloride,盐酸氨基葡萄糖,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride

Target: Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy

N-Acetyl-D-Glucosamine

Cat.No: T4514

Synonym: N-乙酰-D-氨基葡萄糖,NAG,N-Acetyl-2-amino-2-deoxyglucose,Marine Sweet,N-Acetyl-2-amino-2-deoxy-D-glucose,N-乙酰氨基葡萄糖,GlcNAc

Target: Endogenous Metabolite

D-Glucosamine 6-phosphate

Cat.No: T78485

Synonym: Glucosamine-6-phosphate

Target: Endogenous Metabolite

Chitosan (MW 150000)

Cat.No: T1715

Synonym: 壳聚糖,Chitosan,Poly(D-glucosamine),Deacetylated chitin

Target: Antibacterial, Antifungal

2-Deoxy-2-sulfoamino-D-glucose sodium

Cat.No: T3244

Synonym: 氨基葡萄糖硫酸钠盐,N-Sulfo-D-glucosamine sodium salt,N-Sulfo-glucosamine sodium salt,GlcN-2S,2-Deoxy-2-sulfamino-D-glucopyranose

Target: Others, Endogenous Metabolite

Cat.No: TL0006

Synonym: 菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid

Target: Reactive Oxygen Species, HIV Protease

Hyaluronic acid

Cat.No: T3762

Synonym: 透明质酸,Hyaluronate,玻尿酸,hyaluronan

Target: Others, Endogenous Metabolite

Chitobiose dihydrochloride

Cat.No: T38541

Linderaspirone A

Cat.No: TN4441

Target: Others

Cat.No: TN3511

Target: Others

N,N'-Diacetylchitobiose

Cat.No: T40436

Cat.No: T82737

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