165
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2252 |
GLP-1 (9-36) amide
|
Glucagon Receptor | GPCR/G Protein |
GLP-1(9-36)amide 是胰高血糖素样肽-1 (7-36) amide 的主要代谢产物,对人胰腺 GLP-1受体具有拮抗作用。 | |||
T15387 | GLP-1R Antagonist 1 | Glucagon Receptor | GPCR/G Protein |
GLP-1R Antagonist 1 (compound 5d) 是口服有效的、能透过中枢神经系统的,胰高血糖素样肽 1 受体 (GLP-1R) 的非竞争性抑制,其 IC50 值为 650 nM。 | |||
T37890L |
GLP-1(28-36)amide acetate
GLP-1(28-36)amide acetate(1225021-13-5 Free base) |
Antioxidant; Glucagon Receptor | GPCR/G Protein; oxidation-reduction |
GLP-1(28-36)amide acetate 抑制线粒体通透性转变,具有抗氧化、抗糖尿病和心脏保护活性。 | |||
T9579L |
GLP-1 receptor agonist 9 citrate
GLP-1 receptor agonist 9 citrate (2401892-71-3 Free base) |
Glucagon Receptor | GPCR/G Protein |
GLP-1 receptor agonist 9 citrate 是 GLP-1 的激动剂。 | |||
T37891L |
GLP-1(32-36)amide acetate
GLP-1(32-36)amide 醋酸盐,GLP-1(32-36)amide acetate(1417302-71-6 Free base) |
Others | Others |
GLP-1(32-36)amide acetate 是一种五肽,衍生自糖调节激素 GLP-1 的 C 末端。GLP-1(32-36)amide acetate 可抑制糖尿病小鼠的体重增加并调节全身葡萄糖代谢。 | |||
TP1376 |
GLP-1(7-37) acetate(106612-94-6 free base)
GLP-1(7-37) acetate |
Others; Glucagon Receptor | GPCR/G Protein; Others |
GLP-1(7-37) acetate 是肠道胰岛素激素,能够促进葡萄糖诱导的胰岛素分泌。 | |||
T11408 |
Orforglipron
LY3502970,GLP-1 receptor agonist 1 |
Glucagon Receptor | GPCR/G Protein |
Orforglipron (LY3502970; GLP-1 receptor agonist 1) 是一种可口服的胰高血糖素样肽 (GLP-1) 受体激动剂,可用于研究成人肥胖和1型糖尿病。 | |||
T36380 |
GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
|
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GLP-1 amide is a peptide hormone cleaved from proglucagon in the pancreas.1,2 Mice lacking the glucagon receptor (Gcgr-/-) have approximately nine-fold higher levels of total GLP-1 amide, including GLP-1 (1-36) amide and truncated GLP-1 (7-36) amide , in pancreatic tissue compared to wild-type mice.2References1. Schjoldager, B.T., Mortensen, P.E., Christiansen, J., et al. GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans... | |||
TP1306 |
GLP-1(7-37)
|
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GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells. | |||
T37891 |
GLP-1(32-36)amide
|
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GLP-1(32-36)amide is a pentapeptide compound derived from the C terminus of the glucoregulatory hormone GLP-1. This compound has shown potential in inhibiting weight gain and regulating glucose metabolism in diabetic mice[1][2]. | |||
TP1141 |
GLP-1(7-36), amide acetate
GLP-1(7-36) Acetate,Human GLP-1-(7-36)-amide Acetate |
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GLP-1(7-36) Acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells. | |||
T37890 |
GLP-1(28-36)amide
|
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GLP-1(28-36)amide, a C-terminal nonapeptide derived from the cleavage of GLP-1 by neutral endopeptidase (NEP), is a significant product. It functions as an antioxidant and primarily targets the mitochondrion, where it effectively inhibits mitochondrial permeability transition (MPT). This compound exhibits anti-diabetic properties and demonstrates cardioprotection effects[1]. | |||
T11404 | GLP-1 receptor agonist 3 | Others | Others |
GLP-1 receptor agonist 3 is a GLP-1 receptor agonist,Example 4A-1, has EC50s of 1.1 nM and 13 nM in Clone H6 and Clone C6 cell lines assay, respectively. | |||
TP1316 |
GLP-1 moiety from Dulaglutide
|
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GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide which is a glucagon-like peptide 1 receptor (GLP-1) agonist. | |||
T3984 |
GLP-1(7-36), amide
MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide |
Glucagon Receptor | GPCR/G Protein |
GLP-1(7-36), amide (MKC 253) 是一种生理性肠降血糖素,能够刺激胰岛素分泌。 | |||
T9579 |
GLP-1 receptor agonist 9
|
Glucagon Receptor | GPCR/G Protein |
1H-Benzimidazole-6-carboxylic acid 是GLP-1 receptor 激动剂。 | |||
T37892 |
GLP-1(7-36), amide TFA
|
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GLP-1(7-36), amide TFA is a prominent intestinal hormone known to stimulate glucose-induced insulin secretion from β cells[1]. | |||
T11407 |
GLP-1 receptor agonist 2
|
Others | Others |
GLP-1 receptor agonist 2 is a glucagon-like peptide-1 receptor (GLP-1R) agonist. | |||
TP1157 |
GLP-2(1-33)(human)
GLP-2 (human),Glucagon-like peptide 2 (human) |
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GLP-2(1-33) (human) is an enteroendocrine hormone which stimulates the growth of the intestinal epithelium. | |||
T11405 |
GLP-1 receptor agonist 4
|
Others | Others |
GLP-1 receptor agonist 4 is a glucagon-like peptide-1 receptor (GLP-1R) agonist , has an EC50 of 64.5 nM. GLP-1 receptor agonist 4 can be used in the research for treatment of diabetes. | |||
T78571 |
Albiglutide fragment TFA
GLP-1-Gly8 TFA,GLP-1 (7-36) analog TFA |
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Albiglutide fragment (GLP-1 (7-36) analog) TFA为Albiglutide活性片段,代表胰高血糖素样肽-1(GLP-1)模拟物,属长效GLP-1受体激动剂。由GLP-1二聚体抗DPP-4特性与人白蛋白基因融合而成,本化合物在降低糖化血红蛋白(A1C)方面表现显著,主要应用于2型糖尿病(T2D)的相关研究。 | |||
T12710 |
Retagliptin Phosphate
SP 2086,瑞格列汀磷酸盐 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Retagliptin Phosphate (SP 2086) 是一种选择性、竞争性、口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。Retagliptin phosphate 能够用于 2 型糖尿病 (T2DM) 的研究。 | |||
T79348 |
GLP-1 receptor agonist 13
|
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GLP-1 受体激动剂 13 (化合物 (S)-9) 是一种具有EC50值为76 nM的胰高血糖素类似物,其作用机制是激活GLP-1受体。 | |||
T64195 | GLP-1 receptor agonist 7 | ||
GLP-1 receptor agonist 7 是一种有效的胰高血糖素样肽-1 (GLP-1) 激动剂。GLP-1 receptor agonist 7 对 GLP-1 相关疾病、障碍和病症 (包括糖尿病) 表现出研究潜力。 | |||
T74132 |
GLP-1 receptor agonist 8
|
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GLP-1 receptoragonist 8 是一种有效的GLP-1R 激动剂。GLP-1 receptoragonist 8 具有研究糖尿病、肥胖和非酒精性脂肪肝 (NAFLD) 的潜力。 | |||
T75150 | GIP/GLP-1 dual receptor agonist-1 | ||
GIP/GLP-1 dual receptor agonist-1 (化合物 4) 是一种 GIP/GLP-1双受体激动剂。GIP/GLP-1 dual receptor agonist-1 可用于代谢紊乱和脂肪肝病,包括非酒精性脂肪性肝炎 (NASH)、非酒精性脂肪性肝病 (NAFLD) 的研究。 | |||
T75822 |
GLP-1(9-36)amide TFA
|
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GLP-1(9-36)amide TFA, 作为胰高血糖素样肽-1 (7-36)amide的主要代谢产物,是人胰腺GLP-1受体的拮抗剂。 | |||
T76191 |
GLP-1(28-36)amide TFA
|
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GLP-1(28-36)amide TFA,为GLP-1 C-端九肽段,主要通过中性内肽酶(NEP)裂解GLP-1生成。该化合物作为一种抗氧化剂,能靶向线粒体,抑制线粒体通透性转变(MPT),显示出抗糖尿病和心脏保护的功效。 | |||
T76192 |
GLP-1(32-36)amide TFA
|
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GLP-1(32-36)amide TFA,一种衍生自糖调节激素 GLP-1的 C 末端的五肽。GLP-1(32-36)amide TFA 可抑制糖尿病小鼠的体重增加并调节全身葡萄糖代谢。 | |||
T64553 | GLP-1(7-37) TFA salt | ||
The truncated glucagon-like peptides GLP-1(7-37) is naturally occurring peptide product of the preproglucagon gene that are synthesized primarily in the intestine and acts as incretin that are released from the intestine into the bloodstream in response to food and stimulate insulin secretion. GLP-1(7-37) produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in Sprague-Dawley Rats at a dosing rang of 0.5, ... | |||
T80453 |
GLP-1 (1-36) amide (human, rat)
Glucagon-like Peptide 1 (1-36) amide (human, rat) |
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GLP-1(1-36) amide (human, rat)(人类及大鼠的胰高血糖素样肽1(1-36)酰胺)是GLP-1(7-36)酰胺的一种分子变体。该化合物能激发[14C]氨基吡啶在大鼠胃壁细胞的酶分散体中积累。 | |||
T82309 |
GLP-1 (1-36) amide (human, rat) (TFA)
Glucagon-like Peptide 1 (1-36) amide (human, rat) (TFA) |
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GLP-1(1-36) amide (human, rat) TFA为胰高血糖素样肽1(GLP-1)-(7-36)酰胺的分子变体,能够促进[14C]氨基吡啶在大鼠壁细胞的酶分散体中的积累。 | |||
T64180 |
GLP-1R agonist 1
|
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GLP-1R agonist 1 是一种增稠的咪唑衍生物化合物,也是一种 GLP-1R 的有效激动剂。其中胰高血糖素样肽-1 (GLP-1) 是一种肠道降血糖激素,分泌自下消化道 L 细胞。GLP-1R agonist 1 具有研究糖尿病的潜力。 | |||
T76333 |
(Ser8)-GLP-1 (7-36) amide, human
|
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(Ser8)-GLP-1 (7-36) amide, human 为源自胰高血糖素原的胰高血糖素样肽-1酰胺,属于 GLP-1(1-36) 酰胺肽裂解产物。作为肠促胰岛素激素,该化合物促进胰腺 β 细胞在葡萄糖依赖性条件下分泌胰岛素,并对消化道的运动与分泌功能产生影响。 | |||
T82308 |
GLP-2 (1-34) (human)
|
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GLP-2 (1-34) (human) 是一种肠道多肽,其在进食后数分钟内释放,并可用于研究骨重塑过程。 | |||
T76085 |
Glucagon-Like Peptide 1 (GLP-1) (7-36)-Lys (Biotin), amide, human
|
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Glucagon-Like Peptide 1 (GLP-1) (7-36)-Lys (Biotin), amide, human 是一种被 C 端标记的生物素化 GLP-1(7-36) 酰胺。 | |||
TQ0124 |
BETP
|
Glucagon Receptor | GPCR/G Protein |
BETP 是胰高血糖素样肽 (GLP-1) 受体激动剂,能够抑制人和大鼠的GLP-1受体,其EC50值分别为 0.66 μM 和 0.755 μM。 | |||
TP1419L |
HAEGTFT acetate(926018-95-3 free base)
|
Glucagon Receptor | GPCR/G Protein |
HAEGTFT acetate(926018-95-3 free base) 是 GLP-1 肽的 N 端 1-7 个残基。 | |||
TP1382L |
HAEGTFTSDVS acetate
HAEGTFTSDVS acetate(864915-61-7 free base) |
Glucagon Receptor | GPCR/G Protein |
HAEGTFTSDVS acetate 是 GLP-1 的一个 N 末端 1-11 残基,GLP-1 可刺激胰腺 β 细胞分泌胰岛素。 | |||
T36579 |
GLP-1R Agonist DMB
|
Glucagon Receptor | GPCR/G Protein |
GLP-1R Agonist DMB 是胰高血糖素样肽1受体的激动剂(GLP-1R;重组人受体的 KB=26.3nM)。 | |||
T76559 |
Survodutide
BI 456906 |
Glucagon Receptor | GPCR/G Protein |
Survodutide (BI 456906) 是一种胰高血糖素和胰高血糖素样肽 1 (GLP-1) 受体 (GLP Receptor) 双重激动剂,可降低 HbA1c16 型糖尿病的体重。 | |||
TP1111L |
Tirzepatide Acetate(2023788-19-2 free base)
|
Glucagon Receptor | GPCR/G Protein |
Tirzepatide Acetate(2023788-19-2 free base) 是一种双重 GIP / GLP-1 受体激动剂。 | |||
T9226 |
CCG-143140
|
Glucagon Receptor | GPCR/G Protein |
CCG-143140 是一种 GLP-1 受体反向激动剂。 | |||
TP1388 |
HAEGTFTSDVSSYLE
|
Others | Others |
HAEGTFTSDVSSYLE 是一种多肽。GLP-1 类似物包含该序列。 | |||
T19850L |
Semaglutide Acetate
索玛鲁肽醋酸盐,Semaglutide Acetate(910463-68-2 Free base) |
Glucagon Receptor | GPCR/G Protein |
Semaglutide Acetate 是胰高血糖素样肽 1 (GLP-1) 受体的激动剂,可用于治疗 2 型糖尿病的研究。 | |||
T61483 |
GLP-1R modulator C5
|
Glucagon Receptor | GPCR/G Protein |
GLP-1R modulator C5 是一种小分子 GLP-1R 正变构调节剂,通过跨膜位点增强GLP-1与GLP-1R的结合,可用于研究 II 型糖尿病。。 | |||
T8355 |
Exenatide
Exendin-4,Extendin-4 |
Glucagon Receptor | GPCR/G Protein |
Exenatide (Extendin-4) 是一种胰高血糖素样蛋白 1 (GLP-1) 受体激动剂。 | |||
T8876 |
PF-06882961 Tris
UNII-2HJV78O0SS |
Glucagon Receptor | GPCR/G Protein |
PF-06882961 Tris (UNII-2HJV78O0SS) 是一种口服生物可利用的胰高血糖素样肽-1 受体 (GLP-1R) 激动剂。 | |||
T40279 |
GLP-1R modulator L7-028
GLP-1R modulator L7-028 |
cAMP; Glucagon Receptor | GPCR/G Protein |
GLP-1R modulator L7-028 是一种变构调节剂,增强了对 GLP-1 的亲和力和 cAMP 信号转导。 | |||
T32811 |
L-Leucine-1-13C
L-(1-13C)Leucine,(1-13C)Leucine |
Endogenous Metabolite; mTOR | Metabolism; PI3K/Akt/mTOR signaling |
L-Leucine-1-13C (L-Leucine-13C)是一种 13C 标记的 L-Leucine,显著增强了 GLP-4 的亲和力。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T3896 |
Shanzhiside methyl ester
三栀子甙甲酯,山芝皂苷甲酯 |
Glucagon Receptor | GPCR/G Protein |
Shanzhiside methyl ester 是一种小分子胰高血糖素样肽 1 受体激动剂,分离自轮状乳杆菌,能够诱导抗异常性痛觉耐受。 | |||
T19117 |
3-Deoxyglucosone
3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose |
GPX; Glucagon Receptor | GPCR/G Protein; oxidation-reduction |
3-Deoxyglucosone(3-Deoxy-D-glucosone) 是美拉德反应和多元醇反应的中间体途径合成。3-Deoxyglucosone 与蛋白质氨基快速反应形成晚期糖基化末端蛋白 (AGEs)。3-Deoxyglucosone 可使谷胱甘肽过氧化物酶失活,可与低葡萄糖协同作用以增强 GLP-1 分泌,可以作为糖尿病生物学检测的标志物。 | |||
T37526 |
2-Oleoylglycerol
2-Oleoyl Glycerol,2-OG,2-Monoolein |
GPR | Endocrinology/Hormones; GPCR/G Protein |
2-Oleoylglycerol 是一种存在于棕榈仁、葵花籽和米糠中的脂质。2-Oleoylglycerol 可当作一种 GPR119 激动剂,具有神经保护作用,可诱导胰高血糖素样肽 1 (GLP-1) 分泌。2-Oleoylglycerol 可用于非酒精性脂肪性肝炎造模。 | |||
T40977 |
Cinnamtannin A2
肉桂鞣质A2 |
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Cinnamtannin A2, a tetrameric procyanidin, enhances GLP-1 and insulin secretion in mice while also upregulating the expression of corticotrophin releasing hormone. Additionally, Cinnamtannin A2 exhibits antioxidant, anti-diabetic, and nephroprotective effects. |