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Search Results for " ggt "

Targets Recommended: Apoptosis Others

25

抑制剂 & 化合物

2

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T15411	GPNA hydrochloride	Apoptosis; Others	Apoptosis; Others
	GPNA hydrochloride 是一种 γ-谷氨酰转移酶的知名底物，可逆地诱导 A549 细胞凋亡。它是一种特定的谷氨酰胺转运蛋白ASCT2抑制剂，还抑制依赖 Na+的载体，如 SNAT 家族 (SNAT1/2/4/5) 和不依赖 Na+的亮氨酸转运蛋白 LAT1/2。
T25450L	GGTI 2147 FA GGTI2147 FA,GGTI-2147 FA,GGTI 2147 FA(191102-87-1 Free base)	Others	Others
	GGTI 2147 FA 是一种选择性 GGT 抑制剂，在海马体实验中双库林诱导的树突棘密度增加被消除，可能会降低小鼠的学习和记忆能力。
T25450	GGTI 2147 GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147	NF-κB; Rho	Cell Cycle/Checkpoint; NF-κB
	GGTI 2147 降低 Rac1 活性，下调 p65 的表达，改善 OGD/R 诱导的神经元凋亡。
T24088	GGTI-2133 GGTI2133,GGTI 2133	Transferase	Metabolism
	GGTI-2133 是一种有效的仿肽基香叶基转移酶 I 型抑制剂（GGTase I），IC50值为38 nM。GGTI-2133 可抑制小鼠实验性哮喘中炎症细胞向气道的侵袭。
T62379	GGTI-286
	GGTI-286 是一种高效的、具有细胞通透性 GGTase I 抑制剂 (IC50: 2 μM)。GGTI-286 对 NIH3T3 细胞中的 Rap1A 香叶香叶基化的(IC50: 2 μM)抑制作用强于 H-Ras 的法尼化作用(IC50>30 μM)。GGTI-286 也可以有效抑制 K-Ras4B 刺激(IC50: 1 μM)。
T62844	GGTI-2154 hydrochloride
	GGTI-2154 hydrochloride 是一种有效的、选择性的 geranylgeranyltransferase I (GGTase I) 抑制剂 (IC50: 21 nM)。GGTI-2154 hydrochloride 对 GGTase I 的选择性是 FTase (IC50: 5600 nM) 的 200 倍以上。GGTI-2154 hydrochloride 能够用于研究癌症。
T62980	GGTI-286 hydrochloride
	GGTI-286 hydrochloride 是一种 GGTase I 的高效抑制剂 (IC50: 2 μM)，也能够有效抑制 K-Ras4B (IC50: 1 μM)。GGTI-286 hydrochloride 在 NIH3T3 细胞中，对 Rap1A 香叶香叶基化的抑制作用高于 H-Ras 的法尼化作用 (IC50=2和 >30 μM)。
T69205	GGTI-2166
	GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells.
T11396	GGTI-2418	Transferase	Metabolism
	GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors. GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor.
T70157	GGTI-297
	GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase).
T73822	GGTI-286 TFA
	GGTI-286 TFA 是一种高效的细胞通透性 GGTase I 抑制剂，(IC50为 2 μM。在 NIH3T3 细胞中，GGTI-286 TFA 对 Rap1A 香叶香叶基化的抑制作用高于 H-Ras 的法尼化作用 (IC50s=2 和 >30 μM)。GGTI-286 TFA 还能有效抑制 K-Ras4B 刺激，IC50为 1 μM。
T27412	GGTI2417 GGTI-2417
	GGTI2417 is a potent and selective inhibitor of Geranylgeranyltransferase I. GGTI2417 targets RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.
T11397	GGTI298	Others	Others
	GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.
T6844	GGTI298 Trifluoroacetate GGTI 298,GGTI 298 TFA salt	Apoptosis; Transferase; Ras	Apoptosis; GPCR/G Protein; MAPK; Metabolism
	GGTI298 Trifluoroacetate (GGTI 298 TFA salt) 是一种GGTase I 抑制剂，能够抑制Rap1A 且IC50值为3μM，对Ha-Ras 的作用很小IC50值 > 20 μM。
T37446	GGTI-2154
	GGTI-2154 is a potent, selective geranylgeranyltransferase I (GGTase I) inhibitor, boasting an IC50 of 21 nM and demonstrating over 200-fold selectivity against FTase (IC50=5600 nM). Its efficacy and specificity make it a valuable tool for cancer research[1][2].
T22128	OU749	Transferase	Metabolism
	OU749 是一种 γ-谷氨酰转移酶 (GGT) 抑制剂，固有 Ki 值为 17.6 μM。
T5415	γ-GT H-GLA(PNA)-OH,L-谷氨酸 5-(3-甲酸-4硝基苯胺)铵盐	Others	Others
	γ-GT (H-GLA(PNA)-OH) 是一种 γ-谷氨酰转移酶(glutamyl transferase)的底物。
T11282	FGTI-2734	Transferase	Metabolism
	FGTI-2734 是有效的RAS C-末端法尼基转移酶 (FT) 和香叶烯基转移酶-1 (GGT-1) 抑制剂，IC50s 分别为 250 nM 和 520 nM。它可以阻断 KRAS 的膜定位，从而解决 KRAS 耐药性问题，并抑制突变的 KRAS 胰腺肿瘤。
T15379	GGsTop Nahlsgen	Others	Others
	GGsTop is a non-toxic and irreversible inhibitor of γ glutamyl transpeptidase (GGT) (Ki: 170 μM for Human GGT). GGsTop protects hepatic ischemia-reperfusion injury in the rat model. GGsTop shows Kons of 150±10 and 51±3 /(M·s) against E.coli GGT and human GGT, respectively.
T11282L	FGTI-2734 mesylate (1247018-19-4 free base) FGTI-2734 mesylate	Others	Others
	FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.
T11330	FTI-2148 diTFA	Others	Others
	FTI-2148 diTFA is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM, respectively.
T20638	Silthiofam MON 65500,Silthiopham,Latitude,MON65500,MON-65500
	Silthiofam is very effective against Gaeumannomyces graminis var. tritici (Ggt), recently it has been widely used for the take-all control in China. Ggt could cause Wheat take-all.
T11330L	FTI-2148	Others	Others
	FTI-2148 is an inhibitor of RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) (IC50s: 1.4 nM and 1.7 μM, respectively).
T82852	BMI-Glu
	BMI-Glu，一种选择性γ-谷氨酰转肽酶(GGT)荧光探针，具有Km值为69.63 µM的高敏感性，以及优异的水溶性和生物相容性。
T81233	S-(p-Nitrobenzyl)glutathione
	S-(p-Nitrobenzyl)glutathione 是一种竞争性谷胱甘肽酶(GGT)抑制剂，能被大鼠肾微粒体转化成相应的半胱氨酸衍生物。该化合物用于研究谷胱甘肽酶系统中GSH的代谢及其降解过程。

化合物

GPNA hydrochloride

Cat.No: T15411

Target: Apoptosis, Others

Cat.No: T25450L

Synonym: GGTI2147 FA,GGTI-2147 FA,GGTI 2147 FA(191102-87-1 Free base)

Target: Others

Cat.No: T25450

Synonym: GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147

Target: NF-κB, Rho

Cat.No: T24088

Synonym: GGTI2133,GGTI 2133

Target: Transferase

Cat.No: T62379

GGTI-2154 hydrochloride

Cat.No: T62844

GGTI-286 hydrochloride

Cat.No: T62980

Cat.No: T69205

Cat.No: T11396

Target: Transferase

Cat.No: T70157

Cat.No: T73822

Cat.No: T27412

Synonym: GGTI-2417

Cat.No: T11397

Target: Others

GGTI298 Trifluoroacetate

Cat.No: T6844

Synonym: GGTI 298,GGTI 298 TFA salt

Target: Apoptosis, Transferase, Ras

Cat.No: T37446

Cat.No: T22128

Target: Transferase

Cat.No: T5415

Synonym: H-GLA(PNA)-OH,L-谷氨酸 5-(3-甲酸-4硝基苯胺)铵盐

Target: Others

Cat.No: T11282

Target: Transferase

Cat.No: T15379

Synonym: Nahlsgen

Target: Others

FGTI-2734 mesylate (1247018-19-4 free base)

Cat.No: T11282L

Synonym: FGTI-2734 mesylate

Target: Others

Cat.No: T11330

Target: Others

Cat.No: T20638

Synonym: MON 65500,Silthiopham,Latitude,MON65500,MON-65500

Cat.No: T11330L

Target: Others

Cat.No: T82852

S-(p-Nitrobenzyl)glutathione

Cat.No: T81233

Cat. No.	Product Name	Target	Signaling Pathways
T14114	Acivicin 阿西维辛,AT-125,U-42126	Others	Others
	Acivicin (AT-125) is a γ-glutamyl transpeptidase (GGT) inhibitor derived from the Streptomyces sviceus natural product. It possesses anti-cancer and anti-parasitic properties and can effectively cross the blood-brain barrier[1][2].
T77207	Acivicin hydrochloride
	Acivicin hydrochloride (AT-125 hydrochloride)，一种猪链霉菌的天然产物，兼具透过血脑屏障的能力，是γ-谷氨酰转肽酶 (GGT) 的抑制剂，具有抗癌和抗寄生虫的特性。

天然产物

Cat.No: T14114

Synonym: 阿西维辛,AT-125,U-42126

Target: Others

Acivicin hydrochloride

Cat.No: T77207

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06971	GGT1 Protein, Human, Recombinant (His) D22S732,gamma-glutamyltransferase 1,GTG,CD224,D22S672,γ-glut...	Human	HEK293 Cells
	GGT1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.05 kDa and the accession number is P19440.2.
TMPY-00196	GGT5 Protein, Human, Recombinant (His) GGT5,gamma-glutamyltransferase 5,GGTLA1,	Human	HEK293 Cells
	GGT5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.8 kDa and the accession number is P36269-1.
TMPY-03115	GGT1 Protein, Rat, Recombinant (His) gamma-glutamyltransferase 1,γ-glutamyltransferase 1	Rat	HEK293 Cells
	GGT1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.1 kDa and the accession number is P07314.

重组蛋白

GGT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-06971

Species: Human

Expression System: HEK293 Cells

GGT5 Protein, Human, Recombinant (His)

Cat.No: TMPY-00196

Species: Human

Expression System: HEK293 Cells

GGT1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03115

Species: Rat

Expression System: HEK293 Cells

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