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Cat. No.	Product Name	Target	Signaling Pathways
TP1144L	Corticotropin-releasing factor (human) acetate Corticotropin-releasing factor (human) acetate (86784-80-7 Free base)	CRFR	GPCR/G Protein
	Corticotropin-releasing factor (human) acetate 刺激垂体前叶合成和分泌促肾上腺皮质激素。
TP1144	Corticotropin-releasing factor (human) Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human
	Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions b
T37111	Corticotropin-releasing factor (human) (acetate)
	Human CRF acetate is a chemical compound that effectively stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
T20482	Acth (1-4) (1-4) Corticotropin
	Acth (1-4) is the ACTH N-terminal tetrapeptide.
TP1242	1-39-Corticotropin (human)(TFA) Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA)
	Adrenocorticotropic Hormone (ACTH) (1-39) human(TFA),a member of the melanocortin family, is a melanocortin receptor agonist. It stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and
TP1191	CRF, bovine Corticotropin Releasing Factor bovine
	CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.
T80694	β-Corticotropin (swine)
	β-Corticotropin (swine) 为ACTH（肽激素促肾上腺皮质激素）的合成品，具有刺激类固醇释放的功能。
T83665	α-Helical CRF (9-41) TFA α-Helical Corticotropin-Releasing Factor (9-41)
	α-Helical CRF (9-41) 是一种合成的皮质酮释放因子（CRF）拮抗剂。它在0.5至5 µM浓度范围内，能抑制CRF诱导的大鼠前叶垂体细胞释放促肾上腺皮质激素（ACTH）。在体内研究中，α-Helical CRF (9-41) (0.02-0.6 µmol/kg) 能够抑制未经麻醉的完整大鼠体内CRF诱导的ACTH释放，并在0.6 µmol/kg剂量下抑制大鼠应激诱导的ACTH释放。此外，α-Helical CRF (9-41) 在尼古丁诱导的条件性焦虑大鼠模型中增加社交互动时间，并减少小鼠的类似暴饮暴食的乙醇消费。
T83484	[Tyr0] Corticotropin Releasing Factor, ovine
	[Tyr0] Corticotropin Releasing Factor, ovine 是从绵羊分离的促肾上腺皮质激素释放因子/激素。该因子（CRF）为下丘脑激素，能激发促肾上腺皮质激素（ACTH）及β-内啡肽的释放。
TP1190	CRF, bovine TFA (92307-52-3 free base) CRF, bovine TFA,Corticotropin Releasing Factor bovine TFA
	CRF, bovine (TFA) is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM[1]. CRF shows pEC50s of 11.16, 8.53 and 8
T76204	a-Helical Corticotropin Releasing Factor (9-41)
	α-Helical Corticotropin Releasing Factor (9-41) 为corticotropin releasing factor (CRF)的拮抗剂，具有降低体内血浆生长激素(GH)水平的功能。
T76361	[DPro5] Corticotropin Releasing Factor, human, rat
	[DPro5] Corticotropin Releasing Factor, human, rat 是人类和大鼠促肾上腺皮质激素释放因子/激素 R2 的选择性激动剂。作为一种下丘脑激素，促肾上腺皮质激素释放因子 (CRF) 能够促进肾上腺皮质激素 (ACTH) 和 β-内啡肽的分泌。值得注意的是，[DPro5] Corticotropin Releasing Factor, human, rat 并不触发典型的焦虑反应，而是能调控大鼠的学习与记忆过程。
T76362	[Met(O)21] Corticotropin Releasing Factor, ovine
	[Met(O)21] Corticotropin Releasing Factor, ovine 是一种从绵羊下丘脑提取物中分离出的促肾上腺皮质激素释放因子(CRF)。该因子为一类下丘脑激素，主要功能为促进肾上腺皮质激素(ACTH)的分泌。
T76360	a-Helical Corticotropin Releasing Factor (12-41)
	a-Helical Corticotropin Releasing Factor (12-41)，一种含有30个氨基酸的α螺旋促肾上腺皮质激素释放因子/激素类似物。作为下丘脑激素的促肾上腺皮质激素释放因子 (CRF) 能促进肾上腺皮质激素 (ACTH) 分泌，而a-Helical Corticotropin Releasing Factor (12-41) 则抑制该刺激效应。
T4329	CP 376395 CP-316311	CRFR	GPCR/G Protein
	CP 376395 (CP-316311)是一种 CRF1受体选择性拮抗剂。
T12492	Pivagabine CXB-722,匹伐加宾	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Pivagabine (CXB-722) 是疏水性 4-氨基丁酸的衍生物，具有神经调节活性。它可穿透大鼠的血脑屏障，拮抗足部休克对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
T7361	Verucerfont NBI77860,3-(4-甲氧基-2-甲基苯基)-2,5-二甲基-N-[(1S)-1-(3-甲基-1,2,4-恶二唑-5-基)丙基]吡唑并[1,5-A]嘧啶-7-胺,GSK561679	CRFR	GPCR/G Protein
	Verucerfont (NBI77860) 是促肾上腺皮质激素释放因子受体 1 (CRF1) 拮抗剂，作用于 CRF1(IC50:6.1 nM)，CRF2 (IC50>1000 nM)和 CRF-BP (IC50>1000 nM)。
TP1021	Urocortin, human Urocortin (human),Human urocortin,Human urocortin 1,Human urocortin I	CRFR	GPCR/G Protein
	Urocortin, human (Human urocortin I) 是由 40 个氨基酸组成的神经多肽，是选择性 CRF2受体激动剂，作用于 hCRF1(Ki:0.4 nM)、rCRF2α(Ki:0.3 nM)、 mCRF2β(Ki:0.5 nM)。
T31095	Crinecerfont SSR125543,SSR 125543,SSR-125543,SSR125543A,SSR 125543A,SSR-125543A	CRFR	GPCR/G Protein
	Crinecerfont (SSR-125543) 是促肾上腺皮质激素释放因子 1 受体 (CRF1) 的特异性拮抗剂，可用于经典先天性肾上腺增生的研究。
T22577	Antalarmin hydrochloride	CRFR; Immunology/Inflammation related	GPCR/G Protein; Immunology/Inflammation
	Antalarmin hydrochloride 是促肾上腺皮质激素释放因子 1 (CRF1) 的拮抗剂。 Antalarmin hydrochloride 具有抗炎作用并抑制与肠易激综合征相关的应激性胃溃疡。
T16475	Pexacerfont BMS-562086	CRFR	GPCR/G Protein
	Pexacerfont (BMS-562086) 是一种选择性的促肾上腺皮质激素释放因子 (CRF1) 受体拮抗剂，作用于人 CRF1 受体，IC50 为 6.1±0.6 nM。
TP1448L	Astressin acetate Astressin acetate (170809-51-5 Free base)	CRFR	GPCR/G Protein
	Astressin acetate 是促肾上腺皮质激素释放因子 (CRF) 的拮抗剂，对 CRF 结合蛋白具有低亲和力，对克隆垂体受体具有高亲和力 (Ki = 2 nM)。
T9857	Vasopressin antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP)	Endogenous Metabolite	Metabolism
	Vasopressin (argipressin) 是一种由下丘脑神经元合成的环状九肽，是肽原激素合成中的一种激素。Vasopressin 参与下丘脑-垂体-肾上腺轴调节过程，增加无溶质水从肾小管的滤液中重新吸收回循环中的量，收缩小动脉提高压强，增强促肾上腺皮质激素释放因子的刺激作用调节垂体促肾上腺皮质激素分泌。Vasopressin 在神经传导过程中可作为神经递质，与特定的 G 蛋白偶联受体结合发挥作用。
TP2047L	CRF (6-33) acetate(120066-38-8 free base)	CRFR	GPCR/G Protein
	CRF (6-33) acetate(120066-38-8 free base) 是促肾上腺皮质激素释放因子结合蛋白 (CRFBP) 抑制肽；从 CRFBP 中替换 CRF。在体内抑制肥胖大鼠的体重增加并增加运动活动。
TP1238L	ACTH 1-14 acetate(25696-21-3 free base) Adrenocorticotropic Hormone Fragment 1-14 acetate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	ACTH 1-14 acetate(25696-21-3 free base) (Adrenocorticotropic Hormone Fragment 1-14 acetate) 是促肾上腺皮质激素的片段，可调节皮质醇和雄激素的产生。促肾上腺皮质激素 (ACTH)，也称为促肾上腺皮质激素，由垂体前叶产生和分泌。作为对生物应激的反应，ACTH 是下丘脑-垂体-肾上腺轴的重要组成部分。
T27227	E2508 E 2508,E-2508
	E2508 is a selective antagonist of corticotropin-releasing factor 1 receptor.
T23057	NBI-27914 hydrochloride	Others	Others
	corticotropin-releasing factor1 (CRF1) receptor antagonist
T24216	JTC-017 JTC 017
	JTC-017 is an antagonist of Corticotropin-releasing hormone receptor 1.
T26856	BMS-764459
	BMS-764459 is a potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1).
T12276	NVS-CRF38	Others	Others
	NVS-CRF38 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1).
T23067	NGD 98-2 hydrochloride	Others	Others
	corticotropin-releasing factor receptor 1 (CRF1) antagonist
T25864	NGD9002 NGD-9002,NGD 9002
	NGD9002 is a novel generation, topology 2 selective corticotropin releasing factor-1 (CRF-1) receptor antagonist agent.
T71294	BMS-763534
	BMS-763534 is a potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1).
T15214	Emicerfont GW876008	Others	Others
	Emicerfont is an antagonist of the corticotropin-releasing factor type 1 receptor (IC50: 66 nM).
T82698	Codactide BA-41795
	Codactide是一种合成八肽，表现出促肾上腺皮质激素（ACTH）样活性。
T33606	NBI-30545
	NBI-30545 is a potent corticotropin-releasing factor-1 antagonist with sufficient lipophilicity and water solubility for the treatment of stress disorders.
T15145	DMP 696	Others	Others
	DMP 696 is a selective antagonist of corticotropin-releasing hormone receptor 1. It is used for the treatment of anxiety and depression.
T69248	ONO-2333
	ONO-2333 is a corticotropin-releasing factor receptor antagonist, for the treatment of depression and/or anxiety disorders
T69374	NGD 98-2
	NGD 98-2 is a new generation, topology 2 selective orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
TP2095	Astressin 2B
	Potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively). Antagonizes CRF2-mediated inhibition of gastric emptying.
TP1860	Urocortin II, human
	Human urocortin (hUcn) II is a new member of the corticotropin-releasing-factor (CRF) family. It selectively binds to the CRF2 receptor.
TP2048	α-Helical CRF(9-41) α-helical CRF 9-41
	Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).
TP2047	CRF(6-33)(human) CRF (6-33)
	CRF(6-33)(human) is a Corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo.
T75893	CRF(6-33)(human) TFA
	CRF(6-33)(human) TFA 是一种 CRF 结合蛋白配体 (CRF-BP) 抑制剂，与CRF-BP 竞争性结合，但不与突触后 CRF 受体结合。CRF(6-33)(human) TFA 具有抗肥胖作用。
TP1011	ACTH (1-17) α1-17-ACTH
	ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland.
TP1241	Adrenocorticotropic Hormone (ACTH) (18-39), human ACTH (18-39), human
	Adrenocorticotropic Hormone (ACTH) (18-39) is known as the Corticotropin-like Intermediate Lobe Peptide. It stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to those of secretin and carbamylcholine.
T38228	R 121919 hydrochloride
	High affinity corticotropin releasing factor receptor1 (CRF1) antagonist (Ki = 3.5 nM). Reduces stress-induced elevations of plasma ACTH. Anxiolytic and antidepressant in vivo. Orally bioavailable. Chen and Grigoriadis (2005) NBI 30775 (R121919), an orally active antagonist of the corticotropin-releasing factor (CRF) type-1 receptor for the treatment of anxiety and depression. Drug Dev.Res. 65 216 \|Jutkiewicz et al (2005) The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919...
TP2121	Sauvagine
	Corticotropin-releasing factor (CRF) receptor agonist. Ki values are 9.4, 9.9, and 3.8 nM for inhibition of 125I-[D-Tyr1]astressin binding to hCRF-R1, rCRF-R2a and mCRF-R2b respectively.
T26855	BMS-665053 BMS665053
	BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM). In addi
TP2125	Stressin I
	Potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.

化合物

Corticotropin-releasing factor (human) acetate

Cat.No: TP1144L

Synonym: Corticotropin-releasing factor (human) acetate (86784-80-7 Free base)

Target: CRFR

Corticotropin-releasing factor (human)

Cat.No: TP1144

Synonym: Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human

Corticotropin-releasing factor (human) (acetate)

Cat.No: T37111

Cat.No: T20482

Synonym: (1-4) Corticotropin

1-39-Corticotropin (human)(TFA)

Cat.No: TP1242

Synonym: Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA)

Cat.No: TP1191

Synonym: Corticotropin Releasing Factor bovine

β-Corticotropin (swine)

Cat.No: T80694

α-Helical CRF (9-41) TFA

Cat.No: T83665

Synonym: α-Helical Corticotropin-Releasing Factor (9-41)

[Tyr0] Corticotropin Releasing Factor, ovine

Cat.No: T83484

CRF, bovine TFA (92307-52-3 free base)

Cat.No: TP1190

Synonym: CRF, bovine TFA,Corticotropin Releasing Factor bovine TFA

a-Helical Corticotropin Releasing Factor (9-41)

Cat.No: T76204

[DPro5] Corticotropin Releasing Factor, human, rat

Cat.No: T76361

[Met(O)21] Corticotropin Releasing Factor, ovine

Cat.No: T76362

a-Helical Corticotropin Releasing Factor (12-41)

Cat.No: T76360

Cat.No: T4329

Synonym: CP-316311

Target: CRFR

Cat.No: T12492

Synonym: CXB-722,匹伐加宾

Target: GABA Receptor

Cat.No: T7361

Synonym: NBI77860,3-(4-甲氧基-2-甲基苯基)-2,5-二甲基-N-[(1S)-1-(3-甲基-1,2,4-恶二唑-5-基)丙基]吡唑并[1,5-A]嘧啶-7-胺,GSK561679

Target: CRFR

Urocortin, human

Cat.No: TP1021

Synonym: Urocortin (human),Human urocortin,Human urocortin 1,Human urocortin I

Target: CRFR

Cat.No: T31095

Synonym: SSR125543,SSR 125543,SSR-125543,SSR125543A,SSR 125543A,SSR-125543A

Target: CRFR

Antalarmin hydrochloride

Cat.No: T22577

Target: CRFR, Immunology/Inflammation related

Cat.No: T16475

Synonym: BMS-562086

Target: CRFR

Astressin acetate

Cat.No: TP1448L

Synonym: Astressin acetate (170809-51-5 Free base)

Target: CRFR

Cat.No: T9857

Synonym: antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP)

Target: Endogenous Metabolite

CRF (6-33) acetate(120066-38-8 free base)

Cat.No: TP2047L

Target: CRFR

ACTH 1-14 acetate(25696-21-3 free base)

Cat.No: TP1238L

Synonym: Adrenocorticotropic Hormone Fragment 1-14 acetate

Target: Adrenergic Receptor

Cat.No: T27227

Synonym: E 2508,E-2508

NBI-27914 hydrochloride

Cat.No: T23057

Target: Others

Cat.No: T24216

Synonym: JTC 017

Cat.No: T26856

Cat.No: T12276

Target: Others

NGD 98-2 hydrochloride

Cat.No: T23067

Target: Others

Cat.No: T25864

Synonym: NGD-9002,NGD 9002

Cat.No: T71294

Cat.No: T15214

Synonym: GW876008

Target: Others

Cat.No: T82698

Synonym: BA-41795

Cat.No: T33606

Cat.No: T15145

Target: Others

Cat.No: T69248

Cat.No: T69374

Cat.No: TP2095

Urocortin II, human

Cat.No: TP1860

α-Helical CRF(9-41)

Cat.No: TP2048

Synonym: α-helical CRF 9-41

CRF(6-33)(human)

Cat.No: TP2047

Synonym: CRF (6-33)

CRF(6-33)(human) TFA

Cat.No: T75893

Cat.No: TP1011

Synonym: α1-17-ACTH

Adrenocorticotropic Hormone (ACTH) (18-39), human

Cat.No: TP1241

Synonym: ACTH (18-39), human

R 121919 hydrochloride

Cat.No: T38228

Cat.No: TP2121

Cat.No: T26855

Synonym: BMS665053

Cat.No: TP2125

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