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Search Results for " corticosterone "

15

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22708	Darglitazone CP-86325	PPAR	DNA Damage/DNA Repair; Metabolism
	Darglitazone (CP-86325) 是一种噻唑烷二酮，是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢，在 II 型糖尿病中有研究价值。
T68808	11-Dehydrocorticosterone
	11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner. 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11β-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone. Chronic administration 11-dehydro...
T81010	Tetrahydro-11-dehydrocorticosterone
	Tetrahydro-11-dehydrocorticosterone 是一种抑制11β-HSD（11β-羟类固醇脱氢酶）的化合物。
T37725	Tetrahydrodeoxycorticosterone 21-Hydroxypregnanolone,Tetrahydro-11-deoxycorticosterone	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) 是一种有效的 GABAA 受体正变构调节剂 (PAM)，具有神经保护活性，选择性抑制神经类固醇介导的 GABA 诱发电流在 GABAA 受体上的增强，可用于研究神经疾病。
TC0008	Desoxycorticosterone pivalate DOCP	Others	Others
	Deoxycorticosterone (DOCP) is a mineralocorticoid and is an analog of deoxycorticosterone. Deoxycorticosterone pivalate is used in the treatment of canine low adrenal cortex hormones.
T68877	Tetrahydrocorticosterone
	Tetrahydrocorticosterone (THB) is a glucocorticoid (GC) that has anti-inflammatory functions. For instance, 5α THB inhibits inflammatory actions by binding to GC receptor. HPLC studies in rat brains have reported that tetrahydrocorticosterone (THB) isomers are differentially distributed in males and females.
T36926L	Neuropeptide SF (human) aceate	Others	Others
	Neuropeptide SF (human) aceate 是一种神经肽，可增强心室旁 CRH 的释放并增加血浆中的 ACTH 和皮质酮水平。
TP2082L	d[Cha4]-AVP acetate(500170-27-4 free base)	Vasopressin Receptor	GPCR/G Protein
	d[Cha4]-AVP acetate(500170-27-4 free base) 是一种有效的选择性人血管加压素 V1B 受体激动剂（V1B、V1A、催产素和 V2 受体的 Ki 值分别为 1.2、151、240 和 750 nM）。刺激 ACTH 和皮质酮分泌，并在体内表现出微不足道的血管加压活性。
T21466	MK-212 MK 212,MK212
	MK-212 is a 5HT2C-receptor agonist. Intraperitoneal injection of MK-212 in 0.5 and 1.0 mg/kg increased the blood level of corticosterone in mice and reduced their motor activity. In 0.1 and 0.2 mg/kg, the agonist reduced anxiety with no effect on motor ac
TP2082	d[Cha4]-AVP
	Potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo.
T76646	Acetyl-ACTH (7-24) (human, bovine, rat)
	Acetyl-ACTH (7-24) (human, bovine, rat) 可导致 ACTH 诱发的皮质酮和醛固酮释放显著减少。
T61593	11β-HSD1-IN-6
	11β-HSD1-IN-6 is a potent inhibitor of 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs). These enzymes are responsible for catalyzing the conversion of the active glucocorticoids, corticosterone or cortisol, to their respective inactive forms, 11-dehydrocorticosterone (11-DHC) and cortisone. The compound 11β-HSD1-IN-6 specifically targets and inhibits 11β-HSD-1, effectively modulating the interconversion of these glucocorticoids. [1]
T35858	Adrenomedullin (22-52) (human) (trifluoroacetate salt)
	Adrenomedullin (22-52) is a C-terminal fragment of adrenomedullin (1-52) . In vitro, adrenomedullin (22-52) reduces basal corticosterone production in a mixture of rat adrenocortical and adrenomedulllary cells. It also reverses increases in ACTH-stimulated corticosterone production induced by adrenomedullin (1-52). Adrenomedulin (22-52) (0.5 and 5 μg/kg/min) has no effect on basal regional cerebral blood flow but reverses increases in regional cerebral blood flow induced by rat adrenomedullin in...
T70183	Eptapirone fumarate
	Eptapirone, also known as F11440, is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for exam...
T83178	ACTH (6-24) (human) Adrenocorticotropic hormone (6-24)
	ACTH (6-24) (human)（腎上腺皮質激素（6-24））是腎上腺皮質激素的片段。該化合物作為ACTH (1-39) 和 ACTH (5-24) 引起的類固醇生成的競爭性抑制劑，具有相應的Kd值分別為13.4和3.4nM。此外，ACTH (6-24) (human) 能夠抑制 hPTH 1-34 所誘導的皮質酮產生以及cAMP的累積。

化合物

Cat.No: T22708

Synonym: CP-86325

Target: PPAR

11-Dehydrocorticosterone

Cat.No: T68808

Tetrahydro-11-dehydrocorticosterone

Cat.No: T81010

Tetrahydrodeoxycorticosterone

Cat.No: T37725

Synonym: 21-Hydroxypregnanolone,Tetrahydro-11-deoxycorticosterone

Target: GABA Receptor

Desoxycorticosterone pivalate

Cat.No: TC0008

Synonym: DOCP

Target: Others

Tetrahydrocorticosterone

Cat.No: T68877

Neuropeptide SF (human) aceate

Cat.No: T36926L

Target: Others

d[Cha4]-AVP acetate(500170-27-4 free base)

Cat.No: TP2082L

Target: Vasopressin Receptor

Cat.No: T21466

Synonym: MK 212,MK212

Cat.No: TP2082

Acetyl-ACTH (7-24) (human, bovine, rat)

Cat.No: T76646

Cat.No: T61593

Adrenomedullin (22-52) (human) (trifluoroacetate salt)

Cat.No: T35858

Eptapirone fumarate

Cat.No: T70183

ACTH (6-24) (human)

Cat.No: T83178

Synonym: Adrenocorticotropic hormone (6-24)

Cat. No.	Product Name	Target	Signaling Pathways
T0948L	Corticosterone 皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants)	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Corticosterone (Kendall's compound B) 是一种肾上腺皮质类固醇，有盐皮质激素和糖皮质激素的活性，具有口服活性。Corticosterone 参与体内能量、免疫反应和应激反应的调节。
TN6864	Prosaikogenin F (2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol,前柴胡皂苷F	Others	Others
	Prosaikogenin F ((2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol) 是一种单糖苷，具有溶血和抗癌特性。
T3033	Deoxycorticosterone acetate 醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮	Glucocorticoid Receptor; Endogenous Metabolite; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience
	Deoxycorticosterone acetate (Cortexone acetate) 是肾上腺产生的类固醇激素，具有盐皮质激素活性，并作为醛固酮的前体。
T20302	Deoxycorticosterone Desoxycorticosterone,去氧皮质酮,Desoxycorticosteronum,Desoxycortone	Endogenous Metabolite	Metabolism
	Deoxycorticosterone (Desoxycortone) 是由肾上腺产生的类固醇代谢物。 Deoxycorticosterone 是醛固酮前体，具有盐皮质激素活性。
T19614	18-Hydroxycorticosterone	Others	Others
	18-Hydroxycorticosterone is a corticosteroid and corticosterone derivative, which can lead to serious electrolyte imbalances.
TN1601	Effusol 灯心草菲酚,厄弗酚	Caspase	Apoptosis; Proteases/Proteasome
	Effusol 是一种从 Juncus effuses 中分离到的酚类物质，对 DPPH 自由基(IC50:79 μM) 及 ABTS 自由基(IC50:2.73 μM)具有较强的清除活性。它能挽救皮质酮减弱的 CA1 LTP，保护海马功能对抗应激诱导的认知能力下降。
T13489	21-Hydroxypregnenolone	Others	Others
	21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis.
T83268	6-Epiagarotetrol
	6-Epiagarotetrol，一种从Aquilaria sinensis中提取的神经保护剂，对corticosterone诱导的PC12细胞损伤表现出保护效应。
TCA2511	11Beta-hydroxyprogesterone	Sodium Channel	Membrane transporter/Ion channel
	The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.

天然产物

Corticosterone

Cat.No: T0948L

Synonym: 皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants)

Target: Glucocorticoid Receptor, Endogenous Metabolite

Prosaikogenin F

Cat.No: TN6864

Synonym: (2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol,前柴胡皂苷F

Target: Others

Deoxycorticosterone acetate

Cat.No: T3033

Synonym: 醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮

Target: Glucocorticoid Receptor, Endogenous Metabolite, Adrenergic Receptor

Deoxycorticosterone

Cat.No: T20302

Synonym: Desoxycorticosterone,去氧皮质酮,Desoxycorticosteronum,Desoxycortone

Target: Endogenous Metabolite

18-Hydroxycorticosterone

Cat.No: T19614

Target: Others

Cat.No: TN1601

Synonym: 灯心草菲酚,厄弗酚

Target: Caspase

21-Hydroxypregnenolone

Cat.No: T13489

Target: Others

6-Epiagarotetrol

Cat.No: T83268

11Beta-hydroxyprogesterone

Cat.No: TCA2511

Target: Sodium Channel

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