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Search Results for " ct26 "

Targets Recommended: PD-1/PD-L1

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9651	PD-1/PD-L1-IN-9	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-9 是一种有效和具有口服活性的 PD-1/PD-L1 相互作用抑制剂，IC50 值为 3.8 nM。PD-1/PD-L1-IN-9 可以增强免疫细胞对肿瘤细胞的杀伤活性。PD-1/PD-L1-IN-9 在 CT26 小鼠模型中表现出显着的体内抗肿瘤活性。
T72927	IMD-catechol	NF-κB	NF-κB
	IMD-catechol为一种创新的NF-κB免疫调节剂二聚体，能够增强CT26小鼠结肠癌模型的疗效，同时降低辅助毒性至最低。
T34278	Redaporfin F 2BMet,F2BMet,F-2BMet,LUZ11,LUZ 11,LUZ-11
	Redaporfin, also known as F-2BMet or LUZ-11, is a photosensitizer for Photodynamic Therapy (PDT) of cancer. Redaporfin showed a high efficacy in the treatment of male BALB/c mice with subcutaneously implanted colon (CT26) tumours. Vascular-PDT with 1.5 mg
T79653	VISTA-IN-2	Autophagy	Autophagy
	VISTA-IN-2（Compound 1）是一种抑制V结构域Ig抑制因子（VISTA）的化合物，能够诱导通过自噬（Autophagy）机制的VISTA降解。该化合物在克制VISTA介导的免疫抑制方面有效，提升免疫细胞对抗肿瘤的活性，并在CT26小鼠肿瘤模型中激发抗肿瘤免疫响应，进而抑止肿瘤生长。
T72056	KYN-101
	KYN-101是一种高效、选择性的芳香烃受体(AHR)合成拮抗剂,在人HepG2 DRE 荧光素酶报告基因检测中IC50为22 nM,在小鼠Hepa1 Cyp-luc 检测中IC50为23 nM。KYN-101逆转IDO/TDO 介导的肿瘤进展,提高PD-1阻断B16 IDO 荷瘤小鼠和表达内源性高水平IDO 的CT26结直肠癌模型的疗效。
T71884	ß-Carboline-1-carboxylic acid
	β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 µg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells. β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 µg/ml, respectively) but not Hep...
T83779	EP4 Antagonist 14 Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
	EP4 antagonist 14是一种前列腺素E2（PGE2）受体亚型EP4的拮抗剂，其在使用表达人源受体的HEK293细胞的报告基因测定中的IC50值为1.1 nM。它还能抑制PGE2诱导的同种细胞中的β-阿雷斯汀招募（IC50 = 0.9 nM）。EP4 antagonist 14（10 µM）能减少RAW 264.7巨噬细胞中PGE2诱导的mRNA表达，这些mRNA编码Il-4、巨噬细胞甘露糖受体1（Mrc1）、几丁质酶样蛋白3（Chil3）、趋化因子（C-X-C）基序配体1（Cxcl1）、表达在髓样细胞上的触发受体2（Trem2）和精氨酸酶-1（Arg1）。在体内，EP4 antagonist 14（每天30 mg/kg），结合抗PD-1抗体，能够在CT26小鼠结肠癌模型中抑制肿瘤生长并增加CD8+ T细胞对肿瘤的浸润。
T83841	STING Agonist D61 D61,Stimulator of Interferon Genes Agonist D61
	STING激动剂D61（D61）是干扰素基因刺激剂(STING)的激动剂。它在基于细胞的分析中诱导IFN3诱导的分泌性碱性磷酸酶(SEAP)报告基因和IFN-β诱导的报告基因的表达（EC50分别为52.9和116 nM）。D61（4, 6, 和8 µM）增加了编码IFN-β和化学因子（C-X-C基序）配体10（CXCL10）的mRNA的表达以及TANK结合激酶1（TBK1）、IRF3和STING在THP-1单核细胞中的磷酸化。在体内，D61（每隔一天0.25 mg/kg）在CT26小鼠结肠癌模型中减少肿瘤体积，而不影响体重。
T36461	CAY10748 CAY10748
	CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β an...

化合物

PD-1/PD-L1-IN-9

Cat.No: T9651

Synonym:

Target: PD-1/PD-L1

Synonym: F 2BMet,F2BMet,F-2BMet,LUZ11,LUZ 11,LUZ-11

Target: Autophagy

ß-Carboline-1-carboxylic acid

Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14

Target:

STING Agonist D61

Cat.No: T83841

Synonym: D61,Stimulator of Interferon Genes Agonist D61

Target:

CAY10748

Cat.No: T36461

Synonym: CAY10748

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T4672	Brevilin A	Apoptosis; Anti-infection; JAK; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Brevilin A 是从Centipeda minima 中分离的倍半萜内酯，具有抗癌活性。它通过线粒体途径和 PI3K/AKT/mTOR 失活诱导结肠腺癌细胞 CT26 的凋亡和自噬。它是一种选择性JAK-STAT 信号通路抑制剂，通过减弱 JAK 信号和阻塞 STAT3 信号起作用。
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit

天然产物

Brevilin A

Cat.No: T4672

Synonym:

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Cytochalasin D

Cat.No: T3229

Synonym:

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01901	DDX53 Protein, Human, Recombinant (His & Myc) DEAD box protein CAGE,DEAD box protein 53,CAGE,CT	Human	E. coli
	N/A. DDX53 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 76.2 kDa and the accession number is Q86TM3.

重组蛋白

DDX53 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01901

Species: Human

Expression System: E. coli

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