15
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17
Cat. No. | Product Name | Target | Signaling Pathways |
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TP1676L |
C-Reactive Protein (CRP) 201-206 acetate
C-Reactive Protein (CRP) 201-206 acetate(130348-99-1 free base) |
Others | Others |
C-Reactive Protein (CRP) 201-206 acetate (C-Reactive Protein )(130348-99-1 free base) 是 C-反应蛋白的 201-206 片段。 C-反应蛋白 (CRP) 醋酸盐是炎症的原型标志物,是心血管风险标志物,可能促进动脉粥样硬化形成。 | |||
TP1516L |
C-Reactive Protein (CRP) 77-82 acetate
C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base) |
Others | Others |
C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base) 是 C-反应蛋白的 77-82 片段。 C-反应蛋白 (CRP) 是炎症的原型标志物,是心血管风险标志物,可能促进动脉粥样硬化。C-反应蛋白 (CRP) 是一种环状(环状)五聚体蛋白,存在于血浆中,其循环浓度炎症反应而升高。它是一种肝脏来源的急性期蛋白,在巨噬细胞和 T 细胞分泌 IL-6 后会增加。 | |||
TP1592L |
C-Reactive Protein (CRP) 174-185 acetate
C-Reactive Protein (CRP) 174-185 acetate(160369-86-8 free base) |
Others | Others |
C-Reactive Protein (CRP) 174-185 acetate(160369-86-8 free base) 是一种急性期血清蛋白,可响应炎性细胞因子而合成,在动物中产生抗肿瘤作用。片段 CRP (174-185) (RS-83277) 通过显着增强体外人单核细胞和肺泡巨噬细胞的杀肿瘤活性显示出相似的活性。 | |||
TP1592 |
C-Reactive Protein (CRP) (174-185)
C-Reactive Protein (CRP) 174-185 |
||
CRP, an acute phase serum protein synthesized in response to inflammatory cytokines, produces antitumor effects in animals. The fragment CRP (174-185) (RS-83277) shows similar activity by significantly enhancing the tumoricidal activity of human monocytes | |||
TP1676 |
C-Reactive Protein (CRP) (201-206)
C-Reactive Protein (CRP) 201-206 |
Others | Others |
C-Reactive Protein (CRP) (201-206) 是 C-反应蛋白的 201-206 片段。其中C-反应蛋白 (CRP) 是炎症的原型标志物,是心血管风险标志物,可能促进动脉粥样硬化形成。 | |||
TP1516 |
C-Reactive Protein (CRP) (77-82)
C-Reactive Protein (CRP) 77-82 |
||
C-Reactive Protein (CRP) 77-82 is the 77-82 fragment of C-Reactive Protein. C-Reactive Protein (CRP), the prototypic marker of inflammation, is a cardiovascular risk marker and may promote atherogenesis.C-reactive protein (CRP) is an annular (ring-shaped) | |||
T63267 |
P-gp/BCRP-IN-1
|
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P-gp/BCRP-IN-1 (compound 19) 是一种潜在的、相对安全的、口服有效的外排转运蛋白(P-gp 和 BCRP) 抑制剂。P-gp/BCRP-IN-1 通过抑制 P-gp 和BCRP 的外排功能产生耐药性逆转,P-gp/BCRP-IN-1可克服紫杉醇的耐药性,提高紫杉醇的口服生物利用度。 | |||
T79353 |
P-gp/BCRP-IN-2
|
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P-gp/BCRP-IN-2(化合物15)为恶二唑衍生物,作为ABC转运蛋白P-glycoprotein(IC50:1.6 nM)及BCRP(IC50:600 nM)的双重抑制剂。该化合物增强了Doxorubicin针对耐药型人腺癌结肠癌细胞系HT29/DX及MDCK-MDR1细胞的抗增殖效果。 | |||
T83892 |
33-BCRP Inhibitor
33-Breast Cancer Resistance Protein Inhibitor |
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33-BCRP抑制剂是一种乳腺癌耐药蛋白(BCRP)的抑制剂。它使得对米托蒽醌耐药的H460/MX20肺癌细胞对米托蒽醌诱导的细胞死亡更加敏感,无论是单独使用还是与UV辐射联合使用。33-BCRP抑制剂还能够增强表达P-糖蛋白(P-gp,亦称为多药耐药蛋白MDR)的KB-C2表皮癌细胞对秋水仙碱诱导的细胞死亡的敏感性。当使用5 µM浓度时,它能增加米托蒽醌在H460/MX20细胞中的细胞内积累。 | |||
T78639 |
Oxidized ATP trisodium salt
oATP trisodium salt |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
Oxidized ATP (oATP) trisodium salt 是一种P2 受体广泛抑制剂,其不可逆地阻断P2X7R活化并抑制CRP引发的NLRP3炎性体激活,常用于动脉粥样硬化研究。 | |||
T11386 |
Gemcabene calcium
PD-72953 calcium |
Others | Others |
Gemcabene calcium , a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) andexerting anti-inflammatory activity, lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP). | |||
T76947 | Ziltivekimab | ||
Ziltivekimab (COR-001) 是一种人源化抗IL-6单克隆抗体,具有降低血清CRP的效能,并展现出抗炎活性。该化合物在CKD相关的慢性全身性炎症及心血管疾病研究中有潜在应用。 | |||
T62250 |
GPVI antagonist 2
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GPVI antagonist 2 (Compound 1) 是一种潜在的 Glycoprotein VI (GPVI) 拮抗剂,能够作用于胶原蛋白 (IC50: 0.35 μM)、CRP (IC50: 0.80 μM)、convulxin (IC50: 195.2 μM)、凝血酶 (IC50: 81.38 μM)。其中糖蛋白 VI (GPVI) 是一种血小板主要胶原受体,是有效的、安全的抗血栓研究靶点。GPVI antagonist 2 是一种很有前途的抗血小板药物。 | |||
TP2176 |
amyloid A protein fragment [Homo sapiens]
|
Others | Others |
Amyloid A proteins (H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH) are a family of apolipoproteins associated with high-density lipoprotein in plasma. Different isoforms of SAA are expressed constitutively at different levels or in response to inflammatory stimuli. | |||
T61811 |
GPVI antagonist 3
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GPVI antagonist 3 (Compound 2) is a potential antagonist that shows promising antiplatelet activity by selectively inhibiting the interaction between the Glycoprotein VI (GPVI) receptor and its ligands. It demonstrates potent inhibitory effects, with IC50 values of 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin, and 51.74 μM for thrombin. GPVI is a major collagen receptor on platelets, making it an ideal target for safe and effective antithrombotic treatment. Therefore, GPVI antago... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S0896 |
Loureirin A
龙血素 A,龙血素A |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Loureirin A 是一种黄酮类物质,从龙血树中分离得到,能够降低Akt 的磷酸化,具有抗血小板聚集作用。 | |||
TN1849 |
Kuwanon H
|
GPR; Bombesin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Kuwanon H 是分离自桑白皮的黄酮类化合物,具有拮抗非肽类蛙皮素受体的活性。Kuwanon H 特异性抑制细胞内胃泌激素释放肽 CRP 与GRP-preferring 受体的结合,Ki 为 290 nM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00114 |
C-Reactive Protein /CRP Protein, Human, Recombinant (His)
C-reactive protein,MGC88244,PTX1MGC149895,CRP,pentr... |
Human | HEK293 Cells |
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate immunity, opsonization by its properties, complement activation and immunoglobulins receptor binding. CRP is a protein of the acute systemic inflammation and is, therefore, a prime marker of inflammation.The CRP is quantified by immunonephelometry or immunoturbidimetry. C-Reactiv... | |||
TMPY-02473 |
ICOS Protein, Mouse, Recombinant (hFc)
H4,CRP-1,AILIM,Ly115,CCLP,inducible T-cell co-stimu... |
Mouse | HEK293 Cells |
ICOS Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.9 kDa and the accession number is Q9WVS0. | |||
TMPK-01333 |
C-Reactive Protein /CRP Protein, Cynomolgus, Recombinant (His)
C-reactive protein,pentraxin 1,PTX1,PTX1MGC149895,MGC88244,<... |
Cynomolgus | HEK293 Cells |
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate immunity, opsonization by its properties, complement activation and immunoglobulins receptor binding. CRP is a protein of the acute systemic inflammation and is, therefore, a prime marker of inflammation.The CRP is quantified by immunonephelometry or immunoturbidimetry. C-Reactiv... | |||
TMPK-00087 |
ICOS Protein, Human, Recombinant (C136S & C137S, His)
MGC39850,CD278,AILIM,ICOS,CRP-1,CVID1 |
Human | HEK293 Cells |
Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199 amino acids (aa) with a putative 20 aa signal sequence, a 121 aa extracellular domain, a 23 aa transmembrane region, and a 35 aa cytoplasmic domain. ICOS Pro... | |||
TMPY-06209 |
ICOS Protein, Mouse, Recombinant (His)
CCLP,CRP-1,Ly115,AILIM,inducible T-cell co-stimulat... |
Mouse | HEK293 Cells |
ICOS Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.9 kDa and the accession number is Q5SUZ7. | |||
TMPY-01562 |
CSRP1 Protein, Human, Recombinant (His)
cysteine and glycine-rich protein 1,D1S181E,CRP1,CY... |
Human | E. coli |
CSRP1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 21.4 kDa and the accession number is A0A384P5K2. | |||
TMPK-00086 |
ICOS Protein, Human, Recombinant (aa 21-134, His)
CRP-1,ICOS,AILIM,CVID1,CD278,MGC39850 |
Human | HEK293 Cells |
Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199 amino acids (aa) with a putative 20 aa signal sequence, a 121 aa extracellular domain, a 23 aa transmembrane region, and a 35 aa cytoplasmic domain. ICOS Pro... | |||
TMPH-00392 |
Small-CRP Protein, Chlamydia trachomatis, Recombinant (His & SUMO)
|
Chlamydia trachomatis | E. coli |
In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the large cysteine-rich periplasmic protein and the major outer membrane porin. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan. Small-CRP Protein, Chlamydia trachomatis, Recombinant (His & SUMO) is... | |||
TMPY-05651 |
ICOS Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
H4,inducible T-cell co-stimulator,Ly115,CRP-1,CCLP,... |
Mouse | HEK293 Cells |
ICOS Protein, Mouse, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 42.4 kDa and the accession number is Q5SUZ7. | |||
TMPY-04991 |
ICOS Protein, Mouse, Recombinant (rFc)
CCLP,Ly115,CRP-1,AILIM,inducible T-cell co-stimulat... |
Mouse | HEK293 Cells |
ICOS Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 40.2 kDa and the accession number is Q5SUZ7. | |||
TMPH-01176 |
CSRP3 Protein, Human, Recombinant (His & SUMO)
CLP,CRP,Muscle LIM protein,CSRP3,Cardiac LIM protei... |
Human | E. coli |
CSRP3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-03459 |
CRIP2 Protein, Human, Recombinant
CRP2,cysteine-rich protein 2,ESP1,CRIP |
Human | Baculovirus Insect Cells |
CRIP2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 22.6 kDa and the accession number is P52943. | |||
TMPY-03342 |
CRIP2 Protein, Human, Recombinant (His & GST)
CRIP,ESP1,CRP2,cysteine-rich protein 2 |
Human | Baculovirus Insect Cells |
CRIP2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 50.3 kDa and the accession number is P52943. | |||
TMPY-02235 |
CSRP1 Protein, Mouse, Recombinant (His)
cysteine and glycine-rich protein 1,CRP1,AA959891,C... |
Mouse | E. coli |
CSRP1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P97315. | |||
TMPH-00574 |
Adenylate cyclase Protein, E. coli, Recombinant (His)
cyaA,EC:4.6.1.1,Adenylyl cyclase,ATP pyrophosphate-lyase |
E. coli | E. coli |
Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp-cAMP, which then induces its own transcription again. | |||
TMPH-02330 |
Zyxin Protein, Human, Recombinant (His)
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Human | HEK293 Cells |
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. | |||
TMPY-01816 |
Pentraxin 3 Protein, Human, Recombinant (His)
TNFAIP5,pentraxin 3,PTX3,TSG-14 |
Human | HEK293 Cells |
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cycl... |