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Search Results for " cr2 "

Targets Recommended: CCR

19

抑制剂 & 化合物

25

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T14900	CCR2-RA-[R] (5R)-4-乙酰基-1-(4-氯-2-氟苯基)-5-环己基-1,5-二氢-3-羟基-2H-吡咯-2-酮	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR2-RA-[R] 是一种 C-C 趋化因子受体 2 型 (CCR2) 变构拮抗剂，IC50值为103 nM。
T10712	CCR2 antagonist 3 AZD-2927,AZD2927	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR2 antagonist 3 (AZD-2927) 是 CCR2的拮抗剂。
T27682	CCR2 antagonist 5 JNJ-41443532,JNJ-41443532 Free Base,JNJ 41443532,JNJ41443532	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR2 antagonist 5 (JNJ-41443532) 是一种具有选择性和口服活性的 hCCR2 抑制剂，具有良好的结合亲和力 (IC50=37 nM) 和有效的功能拮抗作用 (chemotaxis IC50=30 nM)。JNJ-41443532 对 mCCR2 结合的 Ki 为 9.6 µM，可用于研究炎症性疾病和糖尿病。
T14688	BMS CCR2 22	CCR	Immunology/Inflammation; Microbiology/Virology
	BMS CCR2 22 是一种有效的选择性 CC 型趋化因子受体2拮抗剂，钙通量 IC50为 18 nM，趋化性 IC50为1 nM，结合 IC50为5.1 nM。
T13114	CCR2 antagonist 4 Teijin compound 1	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR2 antagonist 4 (Teijin compound 1) 是高效的、特异性的CCR2拮抗剂，对 CCR2b 的IC50为 180 nM，抑制 MCP-1 诱导的趋化作用的 IC50为 24 nM。
T10905	CXCR2-IN-1	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	CXCR2-IN-1是可渗透中枢神经系统的 CXCR2拮抗剂，pIC50值为9.3。
T61235	CXCR2 antagonist 5
	CXCR2 antagonist 5 (compound 25) 是一种有效的CXCR2拮抗剂。 CXCR2 antagonist 5 显示出有效的CXCR2结合亲和力 (IC50=0.013 μM) 和钙动员 (IC50=0.1 μM)。
T61447	CXCR2 antagonist 4
	CXCR2 antagonist 4 (compound 7) is a highly potent antagonist that inhibits CXCR2 with an IC50 value of 0.13 μM. It also effectively inhibits the cytosolic calcium increase induced by CXCL8, with an IC50 value of 27 μM. CXCR2 antagonist 4 shows promising potential for anticancer research [1].
T19230	CCR2 antagonist 4 hydrochloride Teijin compound 1 hydrochloride	Others	Others
	CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).
T61386	CXCR2 antagonist 2
	CXCR2 antagonist 2 是一种有效的癌症免疫治疗的 CXCR2拮抗剂，IC50值为 95 nM。
T61236	CXCR2 antagonist 7
	CXCR2 antagonist 7 (compound 19) 是一种有效的CXCR2拮抗剂。CXCR2 antagonist 7 显示出有效的CXCR2结合亲和力 (IC50=0.044 μM) 和钙动员 (IC50=0.66 μM)。
T10711	CCR2 antagonist 1	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T37151	NVS-CECR2-1 NVS-CECR2-1
	NVS-CECR2-1 is a potent inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2), a component of chromatin complexes that regulate gene expression controlling development. It binds CECR2 with high affinity (IC50 = 0.047 μM by Alpha screen, Kd = 0.80 μM by ITC). NVS-CECR2-1 demonstrates no crossreactivity in a panel of 48 bromodomains and has no major activity in kinase, protease, and receptor panels. It shows robust activity in cells by FRAP assay, due to its slow off-rate, and has n...
T61356	CXCR2 antagonist 3
	CXCR2 antagonist 3 (compound 11h) is a highly effective antagonist of CXC chemokine receptor 2 (CXCR2). It displays potent activity in inhibiting neutrophil infiltration into the air pouch, with double-digit nanomolar potencies against CXCR2. Moreover, CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs, while enhancing the infiltration of CD3+ T lymphocytes into Pan02 tumor tissues [1].
T60696	CXCR2 antagonist 8
	CXCR2 antagonist 8 是可用于研究胰岛素抵抗的，CXCR2受体的选择性拮抗剂。
T36443	(R,R)-CXCR2-IN-2 (R,R)-CXCR2-IN-2
	(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1]. [1]. Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.
T61359	CXCR2 antagonist 6
	CXCR2 antagonist 6 (compound 35c) 是一种有效的CXCR2拮抗剂。CXCR2 antagonist 6 显示出有效的CXCR2结合亲和力 (IC50=0.43 μM) 和钙动员 (IC50=0.11 μM)。
T36923	CXCR2-IN-2 CXCR2-IN-2
	CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1]. CXCR2-IN-2 (compound 68) (1-10 mg/kg; p.o.; twice daily for 3 days) dose-dependently reduces neutrophil infiltration in vivo in ra...
T33763	NVP CXCR2 20 NVP-CXCR2 20,NVP CXCR2-20,NVP CXCR220
	NVP CXCR2 20 is an effective selective CXCR2 antagonist (IC50 = 40 nM) with oral bioavailability.

化合物

Cat.No: T14900

Synonym: (5R)-4-乙酰基-1-(4-氯-2-氟苯基)-5-环己基-1,5-二氢-3-羟基-2H-吡咯-2-酮

Target: CCR

CCR2 antagonist 3

Cat.No: T10712

Synonym: AZD-2927,AZD2927

Target: CCR

CCR2 antagonist 5

Cat.No: T27682

Synonym: JNJ-41443532,JNJ-41443532 Free Base,JNJ 41443532,JNJ41443532

Target: CCR

Cat.No: T14688

Target: CCR

CCR2 antagonist 4

Cat.No: T13114

Synonym: Teijin compound 1

Target: CCR

Cat.No: T10905

Target: CXCR

CXCR2 antagonist 5

Cat.No: T61235

CXCR2 antagonist 4

Cat.No: T61447

CCR2 antagonist 4 hydrochloride

Cat.No: T19230

Synonym: Teijin compound 1 hydrochloride

Target: Others

CXCR2 antagonist 2

Cat.No: T61386

CXCR2 antagonist 7

Cat.No: T61236

CCR2 antagonist 1

Cat.No: T10711

Target: CCR

Cat.No: T37151

Synonym: NVS-CECR2-1

CXCR2 antagonist 3

Cat.No: T61356

CXCR2 antagonist 8

Cat.No: T60696

(R,R)-CXCR2-IN-2

Cat.No: T36443

Synonym: (R,R)-CXCR2-IN-2

CXCR2 antagonist 6

Cat.No: T61359

Cat.No: T36923

Synonym: CXCR2-IN-2

Cat.No: T33763

Synonym: NVP-CXCR2 20,NVP CXCR2-20,NVP CXCR220

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00842	CD21 Protein, Human, Recombinant (His) CD21,CR2,C3DRSLEB9,EBV receptor,C...	Human	HEK293 Cells
	CD21 mRNA expression, an EBV-entry receptor, was transiently detected in NK cells after exosome treatment, and levels decreased after further culture. CD21 protein expression was also transiently transferred to NK cells after co-culture with an EBV-positive Burkitt lymphoma cell line (Raji) via trogocytosis. However, EBV did not infect NK cells through CD21-mediated trogocytosis.
TMPK-00840	CD21 Protein, Mouse, Recombinant (His) C3DRSLEB9,CR2,CVID7,C3DR,CD21,SLE...	Mouse	HEK293 Cells
	A natural soluble form of CD21 that is cleaved from lymphocyte membrane CD21 circulates in normal human serum. Soluble CD21 retains the capacity to bind iC3b and CD23, the known ligands of membrane CD21. In a similar fashion to IgE complexes, another ligand of CD23, the soluble CD21 was shown to efficiently trigger CD23-signalling pathways in human monocytes.
TMPY-05227	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated TIMD3,hepatitis A virus cellular receptor 2,CD366,K...	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.3 kDa and the accession number is AAL65157.1.
TMPY-01621	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His) TIMD-3,hepatitis A virus cellular receptor 2,HAV	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.3 kDa and the accession number is AAL65157.1.
TMPY-01807	NKp44/NCR2 Protein, Human, Recombinant (His) RP1-149M18.2,LY95,dJ149M18.1,NK-p44,CD336,natural c...	Human	HEK293 Cells
	NKp44/NCR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is O95944-1.
TMPK-00190	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (aa 22-200, His) KIM3,TIM3,TIM 3,TIMD-3,HAVCR2, FLJ1442...	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (aa 22-200, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 20.7 kDa and the accession number is Q8TDQ0-1.
TMPK-00879	CCR2b Protein-VLP, Human, Recombinant C-C CKR-2,CCR2,MCP-1-R,CCR	Human	HEK293 Cells
	The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B. FLNa emerges as an important protein for controlling the internalization and spatial localization of the CCR2B receptor in different dynamic membrane stru...
TMPY-06296	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & Avi), Biotinylated HAVcr-2,KIM-3,TIM3,CD366,HAVCR	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 48.41 kDa and the accession number is Q8TDQ0-1.
TMPY-03318	DcR2/TRAIL R4 Protein, Rhesus, Recombinant (His) tumor necrosis factor receptor superfamily, member ...	Rhesus	HEK293 Cells
	DcR2/TRAIL R4 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.3 kDa and the accession number is XP_001107922.1.
TMPY-01381	DcR2/TRAIL R4 Protein, Human, Recombinant (His) CD264,TRAILR4,tumor necrosis factor recept...	Human	HEK293 Cells
	DcR2/TRAIL R4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.4 kDa and the accession number is Q9UBN6.
TMPJ-00624	TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His) Tim3,HAVcr-2,Timd3,Hepatitis A virus cellu...	Marmoset	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-45 KDa and the accession number is F7I881.
TMPJ-00189	TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His) HAVCR2,Tim-3,TIM3,T cell immunoglobulin an...	Cynomolgus	HEK293 Cells
	T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance...
TMPY-03317	DcR2/TRAIL R4 Protein, Rhesus, Recombinant (hFc) tumor necrosis factor receptor superfamily, member ...	Rhesus	HEK293 Cells
	DcR2/TRAIL R4 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is XP_001107922.1.
TMPY-05463	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (mFc) HAVCR2,TIM3,CD366,TIMD3,hepatitis A virus ...	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.2 kDa and the accession number is Q8TDQ0-1.
TMPY-05481	DcR2/TRAIL R4 Protein, Human, Recombinant (hFc) TRUNDD,TRAIL-R4,tumor necrosis factor receptor supe...	Human	HEK293 Cells
	DcR2/TRAIL R4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.5 kDa and the accession number is Q9UBN6.
TMPJ-00599	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His) TIM3,Hepatitis A virus cellular receptor 2,KIM-3,T-...	Human	HEK293 Cells
	Hepatitis A virus cellular receptor 2（HAVCR2）is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T ...
TMPY-05428	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc) HAVcr-2,KIM-3,Tim-3,TIMD3,HAVCR	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.6 kDa and the accession number is Q8TDQ0-1.
TMPK-00189	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His & Avi), Biotinylated TIM 3,HAVCR2,TIMD-3,TIM3,KIM3,CD366,TIM-3,...	Human	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.8 kDa and the accession number is Q8TDQ0-1.
TMPY-05367	NKp44/NCR2 Protein, Human, Recombinant (His), Biotinylated RP1-149M18.2,CD336,natural cytotoxicity triggering ...	Human	HEK293 Cells
	NKp44/NCR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is O95944-1.
TMPJ-00173	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His) T-cell membrane protein 3,T-cell immunoglobulin and mucin do...	Mouse	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-50 KDa and the accession number is Q8VIM0.
TMPH-01279	CRACR2B Protein, Human, Recombinant (His) CRACR2B,EFCAB4A,EF-hand calcium-b...	Human	E. coli
	Plays a role in store-operated Ca(2+) entry (SOCE).
TMPY-03677	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (hFc) Tim3,TIM-3,hepatitis A virus cellular receptor 2,Ti...	Mouse	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.9 kDa and the accession number is AAL65156.1.
TMPY-00553	TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (hFc) hepatitis A virus cellular receptor 2	Cynomolgus	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is G7P6Q7.
TMPJ-00174	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) T-cell immunoglobulin mucin receptor 3,Hepatitis A virus cel...	Mouse	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-55 KDa and the accession number is Q8VIM0.
TMPY-03424	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (His) hepatitis A virus cellular receptor 2,TIM-3,Timd3,T...	Mouse	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.3 kDa and the accession number is AAL65156.1.

重组蛋白

CD21 Protein, Human, Recombinant (His)

Cat.No: TMPK-00842

Species: Human

Expression System: HEK293 Cells

CD21 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00840

Species: Mouse

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05227

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01621

Species: Human

Expression System: HEK293 Cells

NKp44/NCR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01807

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (aa 22-200, His)

Cat.No: TMPK-00190

Species: Human

Expression System: HEK293 Cells

CCR2b Protein-VLP, Human, Recombinant

Cat.No: TMPK-00879

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06296

Species: Human

Expression System: HEK293 Cells

DcR2/TRAIL R4 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-03318

Species: Rhesus

Expression System: HEK293 Cells

DcR2/TRAIL R4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01381

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His)

Cat.No: TMPJ-00624

Species: Marmoset

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00189

Species: Cynomolgus

Expression System: HEK293 Cells

DcR2/TRAIL R4 Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-03317

Species: Rhesus

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05463

Species: Human

Expression System: HEK293 Cells

DcR2/TRAIL R4 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05481

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00599

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05428

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00189

Species: Human

Expression System: HEK293 Cells

NKp44/NCR2 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05367

Species: Human

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His)

Cat.No: TMPJ-00173

Species: Mouse

Expression System: HEK293 Cells

CRACR2B Protein, Human, Recombinant (His)

Cat.No: TMPH-01279

Species: Human

Expression System: E. coli

TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03677

Species: Mouse

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-00553

Species: Cynomolgus

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His)

Cat.No: TMPJ-00174

Species: Mouse

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03424

Species: Mouse

Expression System: HEK293 Cells

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