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Search Results for " ccr4 "

22

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T39661	CCR4 antagonist 3 CCR4 antagonist 3
	CCR4 antagonist 3 is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antagonist 3 has antitumor activity.
T60336	CCR4 antagonist 3-1	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR4 antagonist 3-1 是一种具有较低活性的趋化因子受体 4 (CCR4) 拮抗剂，对 [125I]TARC (胸腺和活化调节趋化因子) 具有抑制作用，IC50 值为 1.7 μM。CCR4 antagonist 3-1 对放射标记的[125I]TARC和巨噬细胞来源的趋化因子(MDC) 与 CEM 细胞表面的CCR4 受体的结合有抑制作用，并对 TARC 介导的 CEM 细胞的体外迁移有抑制作用，IC50 值为 6.4 μM。
T10713	CCR4 antagonist 2	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.
T39662	CCR4 antagonist 3 hydrochloride
	CCR4 antagonist 3 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antagonist 3 has antitumor activity.
T10639	C-021 dihydrochloride	CCR	Immunology/Inflammation; Microbiology/Virology
	C-021 dihydrochloride 是一种有效的 CCR4 拮抗剂。它有效抑制人和小鼠的功能趋化性，IC50 为 140 nM 和 39 nM。
T21870	C-021 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-	CCR	Immunology/Inflammation; Microbiology/Virology
	C 021 dihydrochloride 是一种 CC 趋化因子受体 4 (CCR4) 拮抗剂，抑制人和小鼠的功能趋化性，IC50分别为 140 和 39 nM。C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) 可有效阻止人 CCL22 衍生的 [35S]GTPγS 与受体结合，IC50为 18 nM。
T11481	GSK2239633A	CCR	Immunology/Inflammation; Microbiology/Virology
	GSK2239633A 是趋化因子受体 CCR4 的变构拮抗剂，将 [125I]-TARC 与人 CCR4 结合的 pIC50 为 7.96。
T4300	AZD2098	CCR	Immunology/Inflammation; Microbiology/Virology
	AZD2098 是选择性CCR4抑制剂，可用于哮喘研究，对人类、大鼠、小鼠和狗的 CCR4 pIC50 值分别为 7.8、8.0、8.0和7.6。
T23646	AF 399 AF399,AF-399
	AF 399 is a CCR4 antagonist. It reverses the tumor-promoting environment.
T3360	ZK 756326 ZK756326 2HCl	CCR	Immunology/Inflammation; Microbiology/Virology
	ZK 756326 是一种选择性的非肽 CCR8 趋化因子受体激动剂（IC50：1.8 μM，在人体内；2.6 μM，在小鼠体内）。对 CCR4/5 和 CXCR3/4 没有活性，比其他 26 种 GPCR 的选择性高 28 倍（对 α2A 和 5-HT 受体的选择性较低）。诱导趋化性并抑制 Env 介导的 (HIV) 细胞-细胞融合。
T15641	K777 APC-3316	P450; Cysteine Protease; CCR	Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome
	K777 是有效的，具有口服活性的，不可逆的半胱氨酸蛋白酶 (cysteine protease) 抑制剂。K777是有效的 CYP3A4 抑制剂(IC50= 60 nM)。K777也是选择性的 CCR4 拮抗剂，显示出强的趋化性抑制作用。K777 对 Cruzain（克鲁斯锥虫的主要半胱氨酸蛋白酶）和组织蛋白酶 B 和 L 具有不可逆的抑制作用。K777 通过靶向组织蛋白酶介导的细胞进入，显示出广谱的抗病毒作用。K777 抑制 EBOV 和 SARS-CoV 病毒的进入，IC50 值分别为 0.87 nM 和 0.68 nM。
T11699	J-113863	CCR	Immunology/Inflammation; Microbiology/Virology
	J-113863 是选择性的 CCR1 (CD18)拮抗剂，有抗炎作用，对人和小鼠 CCR1受体的 IC50值分别为 0.9 和 5.8 nM。它是人 CCR3的强效拮抗剂，还是小鼠 CCR3的弱效拮抗剂，IC50分别为 0.58 和 460 nM。
T26713	AZD-1678 AZD1678,AZD 1678
	AZD-1678 is a potent CCR4 receptor antagonist.
T68984	AF-399/42018025
	AF-399/42018025 is a CC chemokine receptor 4 (CCR4) antagonist.
T76504	CKLF1-C19
	CKLF1-C19 是人类趋化因子样因子 1 (CKLF1) 的 C 端肽。CKLF1-C19 与 CCR4相互作用，抑制 CKLF1 和 CCL17诱导的趋化性。CKLF1-C19 可以通过抑制 CCR3和 CCR4介导的趋化性来抑制过敏性肺部炎症。
T69830	GSK2239633
	GSK2239633 is a potent CC-chemokine receptor 4 antagonist with pIC50 of 7.9. The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2 T-helper lymphocytes to the inflamed airways. Therefore, CCR4 provides an excellent target for anti-inflammatory therapy.
T76245L	CKLF1-C27 TFA
	CKLF1-C27 是 CKLF1 的 C 末端肽，与 CCR4受体结合并激活 ERK1/2通路。CKLF1-C27 可以通过竞争 CCR4受体来消除 CKLF1 对细胞的影响。CKLF1-C27对促进 HUVECs 增殖有很大的作用。CKLF1-C27 具有用于银屑病研究的潜力。
T76245	CKLF1-C27
	CKLF1-C27 是 CKLF1 的 C 末端肽，与CCR4受体结合并激活ERK1/2通路。CKLF1-C27 可以通过竞争CCR4受体来消除 CKLF1 对细胞的影响。CKLF1-C27对促进HUVECs 增殖有很大的作用。CKLF1-C27 具有用于银屑病研究的潜力。
T69183	APC-3316 tosylate
	APC-3316 tosylate is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.
T69182	APC-3316 hydrochloride
	APC-3316 hydrochloride is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.
T69834	Tivumecirnon FLX475
	Tivumecirnon (FLX475) 是一种有效的 CCR4拮抗剂，可以阻断干扰有效抗肿瘤免疫反应的调节性 T 细胞，具有抗肿瘤活性。
T64013	RPT193
	RPT193 是一种口服具有活力的 CCR4 抑制剂，对 Th2 炎性免疫细胞募集到炎症组织表现出抑制作用，在特应性皮炎、哮喘、过敏性炎症等疾病中发挥着重要作用。

化合物

CCR4 antagonist 3

Cat.No: T39661

Synonym: CCR4 antagonist 3

CCR4 antagonist 3-1

Cat.No: T60336

Target: CCR

CCR4 antagonist 2

Cat.No: T10713

Target: Calcium Channel

CCR4 antagonist 3 hydrochloride

Cat.No: T39662

C-021 dihydrochloride

Cat.No: T10639

Target: CCR

Cat.No: T21870

Synonym: 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-

Target: CCR

Cat.No: T11481

Target: CCR

Cat.No: T4300

Target: CCR

Cat.No: T23646

Synonym: AF399,AF-399

Cat.No: T3360

Synonym: ZK756326 2HCl

Target: CCR

Cat.No: T15641

Synonym: APC-3316

Target: P450, Cysteine Protease, CCR

Cat.No: T11699

Target: CCR

Cat.No: T26713

Synonym: AZD1678,AZD 1678

AF-399/42018025

Cat.No: T68984

Cat.No: T76504

Cat.No: T69830

Cat.No: T76245L

Cat.No: T76245

APC-3316 tosylate

Cat.No: T69183

APC-3316 hydrochloride

Cat.No: T69182

Cat.No: T69834

Synonym: FLX475

Cat.No: T64013

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01064	CCR4 Protein, Human, Recombinant (His & SUMO) CMKBR4,CD194,K5-5,CCR-4,...	Human	E. coli
	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expressio...
TMPH-01065	CCR4 Protein-VLP, Human, Recombinant (His) CC-CKR-4,CCR4,CCR-4<...	Human	HEK293 Cells
	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cel...
TMPJ-00993	CCL5 Protein, Rat, Recombinant (E. coli, His) Small-inducible cytokine A5,SIS-δ,C-C motif chemokine 5,T-ce...	Rat	E. coli
	C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leu...
TMPH-02317	YTHDF1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradatio...

重组蛋白

CCR4 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01064

Species: Human

Expression System: E. coli

CCR4 Protein-VLP, Human, Recombinant (His)

Cat.No: TMPH-01065

Species: Human

Expression System: HEK293 Cells

CCL5 Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPJ-00993

Species: Rat

Expression System: E. coli

YTHDF1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02317

Species: Human

Expression System: P. pastoris (Yeast)

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