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30

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T25779	MDK-4683 MDK 4683,CA IX/XII Inhibitor
	MDK-4683, also known as CA IX/XII Inhibitor, is a hCA IX and hCA XII inhibitor.
T62387	CA IX-IN-1
	CA IX-IN-1 (compound 12g) 是一种有效的、高度选择性的 hCA IX 抑制剂 (IC50: 7 nM)，表现出抗肿瘤作用。
T2017	U-104 NSC-213841,MST-104	Carbonic Anhydrase	Metabolism
	U-104 (NSC-213841) 是 CA IX 和 CA XII 碳酸酐酶 (CA) 抑制剂，其 Ki 分别为 45.1 nM 和 4.5 nM。小鼠模型中，它能够表现出明显的抑制肿瘤生长的作用。
T36758	CAIX Inhibitor S4 S4	Carbonic Anhydrase	Metabolism
	CAIX Inhibitor S4 (S4) 是一种有效的碳酸酐酶 IX/XII 抑制剂，Ki 分别为 7 nM 和 2 nM。 CA II 和 CA I 的 Ki 分别为 546 和 5600 nM。
T77631	Enpp/Carbonic anhydrase-IN-2	Apoptosis; PDE; Carbonic Anhydrase	Apoptosis; Metabolism
	Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
T67775	Enpp/Carbonic anhydrase-IN-1	PDE; Carbonic Anhydrase	Metabolism
	Enpp/Carbonic anhydrase-IN-1 (compound 1e) 是有效的 Enpp 和 carbonic anhydrase 抑制剂。Enpp/Carbonic anhydrase-IN-1抑制 NPP1、NPP2、NPP3、CA-II、CA-IX 的 IC50 值分别 1.36、1.35、3.00、0.88、1.02 µM。Enpp/Carbonic anhydrase-IN-1 选择性抑制癌细胞的增殖，对正常细胞毒性较低。
T60351	Acetazolamide sodium OT-302 sodium	Carbonic Anhydrase	Metabolism
	Acetazolamide sodium (OT-302 sodium) 是一种高效的碳酸酐酶 (CA)IX抑制剂，具有利尿、抗淋球菌和降压活性，可用于癫痫、青光眼、水肿和高原反应等适应症。
T60745	hCAIX-IN-5	Carbonic Anhydrase	Metabolism
	hCAIX-IN-5 是一种具有选择性的 hCAIX 抑制剂，对 hCAI, hCAII，hCAIV，hCAIX 的有抑制作用， Ki值分别为 >10000, >10000, 130.7, 829.1 nM。
T79753	hCAIX/XII-IN-8	Carbonic Anhydrase	Metabolism
	hCAIX/XII-IN-8（compound 3g）是一种对人类（碳酸酐酶）CA IX和XII高效的抑制剂，Ki值分别为8.5和6.7 nM。该化合物对与肿瘤相关的膜结合异构体hCA IX和XII表现出显著的抑制作用，且相对于胞内异构体hCA I和II具有较高的选择性。
T16557	PNU-159682	Topoisomerase	DNA Damage/DNA Repair
	PNU-159682 是蒽环类新霉素的代谢产物，是一种 DNA 拓扑异构酶 II 抑制剂，具有出色的细胞毒性。
T63005	Carbonic anhydrase inhibitor 11
	Carbonic anhydrase inhibitor 11 (compound VI) 是一种有效的、选择性碳酸酐酶抑制剂，能够作用于 CA II (Ki: 40 nM)、CA IX (Ki: 39 nM) 和 CA XII (Ki: 900 nM)。
T73177	hCAII-IN-9	Carbonic Anhydrase	Metabolism
	hCAII-IN-9 是一种强效的碳酸酐酶抑制剂，对hCA II、hCA IX 和hCA XII 有抑制作用，IC50 分别为 1.18 μM 和 0.17 μM , and 2.99 μM 。hCAII-IN-9 没有血脑屏障透过性。
T73030	hCAIX-IN-14
	hCAIX-IN-14 是一种有效的人类CA IX 抑制剂，Ki 值为 134.8 nM。
T83137	ALP/Carbonic anhydrase-IN-1	Carbonic Anhydrase	Metabolism
	ALP/Carbonic anhydrase-IN-1（Compound 1e）为碳酸酐酶（CA）与碱性磷酸酶（ALP）的双效抑制剂。对CA-II、CA-IX、CA-XII和ALP具有显著抑制活性，其IC50值分别为0.44 µM、1.61 µM、0.51 µM和0.107 µM。
T62914	NSC 828467
	NSC 828467 是前五大 CA-IX 抑制剂之一，具有显著的体外抗癌作用 (IC50: 27.2 nM)。
T74978	DPP IV/hCA II-IN-1
	DPP IV/hCA II-IN-1 是一种有效的选择性二肽肽酶 IV (DPP IV) 和碳酸酐酶 (CA) 抑制剂，抑制 DPP IV 的 IC50值为 0.049 μM, 抑制 CA II、CA VB、CA VA、CA IX、CA I 和 CA IV 的 Ki 值分别为 0.0361、0.0428、0.0941、0.1328、0.2615 和 3.034 μM。
T72840	hCAIX/XII-IN-6
	hCAIX/XII-IN-6 是具有口服活性的碳酸酐酶（CA）抑制剂，能够抑制人体 CA 亚型 hCA I、II、IV、IX 及 XII，其 Ki 值分别为 6697 nM、2950 nM、4093 nM、4.1 nM 和 7.7 nM。适用于类风湿关节炎（RA）研究。
T63731	Carbonic anhydrase inhibitor 9
	Carbonic anhydrase inhibitor 9 是碳酸酐酶 (CA) 的有效抑制剂，能够作用于 hCA II (Ki: 56.4 nM) 和 IX (Ki: 56.9 nM)，表现出抗增殖效果。
T63753	hCAIX-IN-3
	hCAII-IN-3 (compound 7e) 是选择性的、有效的碳酸酐酶 (CA II/IX) 抑制剂，他们的 Kis 值分别为 124.2 和 30.5 nM。hCAII-IN-1 对癌症疾病表现出研究潜力。
T60930	CAXII-IN-1
	CAXII-IN-1 (Compound 17) 具有抗肿瘤活性，它是 CA XII 的选择性抑制剂。CAXII-IN-1 对 hCA XII 和 hCA IX 的 Ki 值分别为 3.8 nM 和 56.0 nM。
T63752	hCAII-IN-1
	hCAII-IN-1 (compound 7f) 是选择性的、有效的碳酸酐酶 (CA II/IX) 抑制剂，他们的 Kis 值分别为 1.2 和 113.6 nM。hCAII-IN-1 对癌症疾病表现出研究潜力。
T79540	hCA/VEGFR-2-IN-1	Carbonic Anhydrase	Metabolism
	hCA/VEGFR-2-IN-1 是一种高效的双靶点抑制剂，对 hCA IX 和 hCA XII 两种碳酸酐酶（CA）具有极低的Ki值，分别为8.3 nM和4.7 nM。同时，hCA/VEGFR-2-IN-1 也是一种有效的 VEGFR-2 抑制剂，其 IC50 值仅为26.3 nM，并且显示出抗癌活性。
T72164	Enpp/Carbonic anhydrase-IN-2
	Enpp/Carbonic anhydrase-IN-2 是一种有效的 Enpp 和 carbonic anhydrase 抑制剂，对 NPP1、NPP2、NPP3、CA-IX, CA-XII 的 IC50值分别 1.13、 1.07、 0.74、 0.33、 0.68。Enpp/Carbonic anhydrase-IN-2 对癌细胞具有抗增殖活性，对正常细胞具有低细胞毒性。Enpp/Carbonic anhydrase-IN-2 诱导细胞凋亡 (Apoptosis)。
T61842	Carbonic anhydrase inhibitor 14
	Carbonic anhydrase inhibitor 14 (Compound 8b) is a potent CA inhibitor, exhibiting K i values of 1203, 99.7, 9.4, and 27.7 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. Additionally, it effectively inhibits CDK2 with an IC 50 of 20.3 μM. Furthermore, Carbonic anhydrase inhibitor 14 demonstrates significant antitumor activity [1].
T61032	Carbonic anhydrase inhibitor 10
	Carbonic anhydrase inhibitor 10 可用于研究癌症，它对 MCF-7 癌细胞表现出抗增殖活性， IC50值为 11.9 μM。Carbonic anhydrase inhibitor 10 是 hCA IX 的有效抑制剂，Ki 值为 6.2 nM。
T60602	hCAIX/XII-IN-5
	hCAIX/XII-IN-5 (Coumarin 9a) 是一种碳酸酐酶 (CA) 抑制剂，具有出色的 hCA IX/XII 选择性，对 hCA I 和 hCA II 的Ki 值分别为 93.9 和 85.7 nM。hCAIX/XII-IN-5 对癌细胞具有抗增殖活性，可延迟细胞周期并诱导细胞凋亡。
T35876	Chlorthalidone Impurity G
	Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) an...
T73029	hCAIX-IN-15	Carbonic Anhydrase	Metabolism
	hCAIX-IN-15，一种高效hCA IX抑制剂，Ki值仅为38.8 nM，展现出优秀的广谱抗癌活性，适用于癌症研究。
T79748	hCAIX/XII-IN-7	Carbonic Anhydrase	Metabolism
	hCAIX/XII-IN-7（compound 3e）为高效的hCA IX与XII抑制剂，对hCA I、II、IX与XII的Ki值分别为3.2 nM、9.2 nM、503.7 nM及59 nM，显示其在缺氧肿瘤研究中的应用潜力。
T78705	COX-2-IN-30	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-30 是苯磺酰胺衍生的口服活性 COX/5-LOX 双重抑制剂，其 IC50 值为 COX 同源物为 49 nM、5-LOX 同源物为 10.4 μM。此化合物还能纳摩尔级别 Ki 值抑制 hCA IX 与 hCA XII 亚型。COX-2-IN-30 具备镇痛、抗炎、致溃疡作用，不引发急性胃部反应。

化合物

Cat.No: T25779

Synonym: MDK 4683,CA IX/XII Inhibitor

Cat.No: T62387

Cat.No: T2017

Synonym: NSC-213841,MST-104

Target: Carbonic Anhydrase

CAIX Inhibitor S4

Cat.No: T36758

Synonym: S4

Target: Carbonic Anhydrase

Enpp/Carbonic anhydrase-IN-2

Cat.No: T77631

Target: Apoptosis, PDE, Carbonic Anhydrase

Enpp/Carbonic anhydrase-IN-1

Cat.No: T67775

Target: PDE, Carbonic Anhydrase

Acetazolamide sodium

Cat.No: T60351

Synonym: OT-302 sodium

Target: Carbonic Anhydrase

Cat.No: T60745

Target: Carbonic Anhydrase

Cat.No: T79753

Target: Carbonic Anhydrase

Cat.No: T16557

Target: Topoisomerase

Carbonic anhydrase inhibitor 11

Cat.No: T63005

Cat.No: T73177

Target: Carbonic Anhydrase

Cat.No: T73030

ALP/Carbonic anhydrase-IN-1

Cat.No: T83137

Target: Carbonic Anhydrase

Cat.No: T62914

DPP IV/hCA II-IN-1

Cat.No: T74978

Cat.No: T72840

Carbonic anhydrase inhibitor 9

Cat.No: T63731

Cat.No: T63753

Cat.No: T60930

Cat.No: T63752

hCA/VEGFR-2-IN-1

Cat.No: T79540

Target: Carbonic Anhydrase

Enpp/Carbonic anhydrase-IN-2

Cat.No: T72164

Carbonic anhydrase inhibitor 14

Cat.No: T61842

Carbonic anhydrase inhibitor 10

Cat.No: T61032

Cat.No: T60602

Chlorthalidone Impurity G

Cat.No: T35876

Cat.No: T73029

Target: Carbonic Anhydrase

Cat.No: T79748

Target: Carbonic Anhydrase

Cat.No: T78705

Target: COX

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00283	Carbonic Anhydrase 9 Protein, Human, Recombinant (Avi & His), Biotinylated G250,P54/58N,Carbonic Anhydrase IX,CA<...	Human	HEK293 Cells
	Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA9 is a transmembrane enzyme expressed primarily in carcinoma cells. It is one of the best markers for hypoxia and for RCC...
TMPK-00283	CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi) RCC,EC 4.2.1.1,CA9,P54/58N,MN,CA-IX	Human	HEK293 Cells
	CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The...
TMPK-00524	CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His) CAIX,CA9,P54/58N,RCC,G250,EC 4.2....	Cynomolgus	HEK293 Cells
	CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The pred...

重组蛋白

Carbonic Anhydrase 9 Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00283

Species: Human

Expression System: HEK293 Cells

CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00283

Species: Human

Expression System: HEK293 Cells

CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00524

Species: Cynomolgus

Expression System: HEK293 Cells

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