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21

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3502	C29	TLR	Immunology/Inflammation
	C29 是 Toll 样受体 2 抑制剂，可阻断 hTLR2/1 和 hTLR2/6 信号，IC50值分别为 19.7 和 37.6 μM。
T11539	HCV-IN-29	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	HCV-IN-29 是一种丙型肝炎病毒抑制剂。
T18622	BnOH-NH-bis-(C2-S)-propane-O-isoprene ester PROTAC Linker 29	Others	Others
	BnOH-NH-bis-(C2-S)-propane-O-isoprene ester (PROTAC Linker 29) is an alkyl ether-based linker primarily utilized in the synthesis of PROTACs.
T17206	UPGL00004	Others; Glutaminase	Others; Proteases/Proteasome
	UPGL00004 是一种有效的谷氨酰胺酶 C (GAC) 抑制剂，其 IC50为29 nM。UPGL00004 对 GAC 的 Kd 为27 nM。UPGL00004 对高度侵袭性三阴性乳腺癌细胞系的增殖具有很强的抑制作用。
T6318	AZ 628	Apoptosis; Raf	Apoptosis; MAPK
	AZ 628 是一种泛Raf 激酶抑制剂，抑制B-Raf、B-RafV600E 和c-Raf-1，IC50分别为 105、34和 29 nM。
T6351	MGCD-265 analog MGCD-265,Glesatinib	Apoptosis; VEGFR; c-Met/HGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	MGCD-265 analog (Glesatinib) 是一种口服生物可利用的多靶点酪氨酸激酶抑制剂，具有抗肿瘤活性，对 c-Met 和 VEGFR2 的 IC50 分别为 29 nM 和 10 nM。
T4426	CEP-40783 CEP 40783,RXDX-106	c-Met/HGFR; TAM Receptor	Tyrosine Kinase/Adaptors
	CEP-40783 (RXDX-106) 是一种有口服活性的，高效的，选择性的 AXL (IC50:7 nM) 和 c-Met (IC50:12 nM) 抑制剂。
T11540	HCV-IN-3	Others	Others
	HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor (IC50: 20 μM; Kd: 29 μM).
T63590	c-Met-IN-10
	c-Met-IN-10 是高效的 c-Met 激酶抑制剂 (IC50: 16 nM)。c-Met-IN-10 能够抑制癌细胞 A549、H460 和 HT-29 的活性，通过抑制 HT-29 细胞集落形成，进而诱导 HT-29 和 A549 细胞凋亡 apoptosis，抑制 A549 细胞移动。c-Met-IN-10 能够用于抗癌研究。
T125696	Scheffursoside C
	Scheffursoside C 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125696，CAS号为 160669-29-4。
TP1231	β-Amyloid (29-40) Amyloid beta-protein(29-40),β-Amyloid 29-40
	β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties related to those of fusion peptides of viral proteins. The fusion of liposomes can be induced by th
T79715	c-Met-IN-19	c-Met/HGFR	Tyrosine Kinase/Adaptors
	c-Met-IN-19（Compound 21j）作为c-Met抑制剂，呈现出对A549、HT-29、SGC-7901、MDA-MB-231细胞系的细胞毒效应，其IC50分别为0.25、0.36、0.98、0.76 μM，并具有较高的抑制活性（IC50: 1.99 nM）。
T36913	17-Epiestriol
	17-Epiestriol is a metabolite of estrone .1It is formed from estroneviaa 16α-hydroxy estrone intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor α (ERα) and ERβ with relative binding affinities of 29 and 80 compared with 17β-estradiol .2 1.Brinton, L.A., Trabert, B., Anderson, G.L., et al.Serum estrogens and estrogen metabolites and endometrial cancer risk among postmenopausal womenCancer Epidemiol. Biomarkers Prev.25(7)1081-1089(2016) 2.Kuiper, G.G.J.M., Lemme...
T83738	SMAP 29 (ovine) TFA Sheep Myeloid Antimicrobial Peptide 29
	SMAP 29是一种抗微生物肽，同时也是绵羊防御素前体肽的C末端切割产物。在低盐和高盐条件下，对P. aeruginosa菌株PAO1具有杀菌作用，该作用在能量依赖的发光测定中表现出来（EC50s分别为0.05和0.06 µM）。它还能够以浓度依赖的方式引起绵羊红细胞的溶血。
T37922	7(Z),11(Z)-Pentacosadiene
	Unsaturated, long-chain hydrocarbons are found on the cuticles of insects and can act as pheromones. In mature Drosophila melanogaster, certain cuticular hydrocarbons are sexually dimorphic: males synthesize 23- and 25-C monoenes and females produce 27- and 29-C dienes. Each of these lipids plays specific roles in regulating male sexual behavior, with dienes stimulating courtship. 7(Z),11(Z)-Pentacosadiene is a 25-C hydrocarbon that is found in low abundance on cuticles of mature Drosophila fema...
T36929	Pal-KTTKS (acetate)
	Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS...
T36431	7,10-dihydroxy-8(E)-Octadecenoic Acid
	7,10-dihydroxy-8(E)-Octadecenoic acid is a hydroxy fatty acid and metabolite of oleic acid that is produced byP. aeruginosafrom vegetable oils.1It is active against the food-borne pathogenic bacteriaS. aureus,S. typhimurium,L. monocytogenes,B. subtilis, andE. coli(MIC50s = 31.3, 125, 125, 62.5, and 250 μg/ml, respectively), as well as the plant pathogenic bacteriaErwinia,R. solanacearum,C. glutamicum, andP. syringae(MIC90s = 125, 125, 250, and 500 μg/ml, respectively).2,1 1.Sohn, H.-R., Bae, J.-...
T36991	Monascuspiloin
	Monascuspiloin is a fungal metabolite that has been found inM. pilosusM93-fermented rice.1It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 μM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 ...
T36668	Geranylgeranoic Acid
	Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also...
T37632	TFM
	TFM is a piscicide.1It is toxic to sea lamprey (P. marinus) with LC50values ranging from 1.97 to 2.11 and 2.05 to 2.21 mg/L for sac and swim-up fry, respectively, 1.6 to 2.45 mg/L for juveniles, and 1.6 to 1.63 mg/L for adults. It is also toxic to juvenile lake sturgeon (A. fulvescens) less than 100 mm in size but not to a variety of other fish species. TFM (50 μM) uncouples oxidative phosphorylation by 22 and 28% in isolated sea lamprey and rainbow trout (O. mykiss) liver, respectively.2Formula...
T12925	Sitravatinib malate MGCD516 malate,MG-516 malate	TAM Receptor	Tyrosine Kinase/Adaptors
	Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively.) , shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

化合物

Cat.No: T3502

Target: TLR

Cat.No: T11539

Target: HCV Protease

BnOH-NH-bis-(C2-S)-propane-O-isoprene ester

Cat.No: T18622

Synonym: PROTAC Linker 29

Target: Others

Cat.No: T17206

Target: Others, Glutaminase

Cat.No: T6318

Target: Apoptosis, Raf

MGCD-265 analog

Cat.No: T6351

Synonym: MGCD-265,Glesatinib

Target: Apoptosis, VEGFR, c-Met/HGFR

Cat.No: T4426

Synonym: CEP 40783,RXDX-106

Target: c-Met/HGFR, TAM Receptor

Cat.No: T11540

Target: Others

Cat.No: T63590

Scheffursoside C

Cat.No: T125696

β-Amyloid (29-40)

Cat.No: TP1231

Synonym: Amyloid beta-protein(29-40),β-Amyloid 29-40

Cat.No: T79715

Target: c-Met/HGFR

Cat.No: T36913

SMAP 29 (ovine) TFA

Cat.No: T83738

Synonym: Sheep Myeloid Antimicrobial Peptide 29

7(Z),11(Z)-Pentacosadiene

Cat.No: T37922

Pal-KTTKS (acetate)

Cat.No: T36929

7,10-dihydroxy-8(E)-Octadecenoic Acid

Cat.No: T36431

Cat.No: T36991

Geranylgeranoic Acid

Cat.No: T36668

Cat.No: T37632

Sitravatinib malate

Cat.No: T12925

Synonym: MGCD516 malate,MG-516 malate

Target: TAM Receptor

Cat. No.	Product Name	Target	Signaling Pathways
TN1993	Norsanguinarine	Antifection	Microbiology/Virology
	Norsanguinarine has antifungal activity, it exhibits 100 % inhibition of A. brassicicola and C. maculans at 1000 ppm whereas. It shows significant cytotoxic activities (ED (50) values < 4 microg/ml) against P-388, KB16, A549, and HT-29 cell lines.
TN3870	Iriflophenone 2-O-Rhamnoside Dimethylmatairesinol	Others	Others
	Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung c

天然产物

Norsanguinarine

Cat.No: TN1993

Target: Antifection

Iriflophenone 2-O-Rhamnoside

Cat.No: TN3870

Synonym: Dimethylmatairesinol

Target: Others

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