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36

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T80226	r8 Bid BH3
	r8 Bid BH3是一种促凋亡的生物活性肽，属于"BCL-2家族"中的“仅具BH3功能域”的亚群，对Bcl-2表达的人类白血病细胞系显示出致死性。作为Bcl-2拮抗剂，它具备治疗癌症的潜力。此外，多聚-D-精氨酸（d-异构体，标记为rrrrrrrr）被融合到Bid BH3肽上，以提高其被细胞摄取的能力。
T80224	Bid BH3 (80-99)
	Bid BH3 (80-99) 是一种具有促凋亡功能的生物活性肽，属于BCL-2蛋白家族中的"BH3仅限"(BOPS)亚群。作为第一个能够结合并激活Bcl-2、Bax和Bak的BOP，Bid扮演引发细胞凋亡的关键角色。它通过从细胞质迁移到线粒体膜来失活Bcl-2或激活Bax。特别地，在N末端位置的谷氨酰胺(Q)或谷氨酸(E)，会自然转化为pGlu形式，其疏水性γ-内酰胺环被认为有助于增强肽针对胃肠道蛋白酶的稳定性。焦谷氨酰肽通常被划分为这类生物活性肽的一个常见子集，并且在HPLC分析中，作为评估肽纯度的重要指标被考虑在内。
T80225	Bid BH3 (80-99), FAM labeled
	Bid BH3 (80-99), FAM标记，是一种被5-FAM标记并具有生物活性的肽。
T5827	BI-6C9	Apoptosis; Others; Mitochondrial Metabolism	Apoptosis; Metabolism; Others
	BI-6C9 是一种高特异性的 BH3 相互作用结构域抑制剂，可阻止线粒体外膜电位和线粒体分裂，并保护细胞免受线粒体凋亡诱导因子释放和不依赖 caspase 的细胞死亡。
T17314	(±)-BI-D	Others	Others
	(±)-BI-D is an effective ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site (IC50: 2.4–2.9 μM).
T2148	Carbidopa monohydrate Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa monohydrate (S(-)-Carbidopa) 是一种外周型脱羧酶抑制剂，可用于帕金森病的研究。它是一种选择性芳香烃受体 (AhR) 调节剂。它抑制胰腺癌细胞和肿瘤生长。
T6863	Isosorbide Mononitrate 单硝酸异山梨酯,Isosorbide-5-mononitrate,5-单硝酸异山梨酯,Imdur,Mononit,Corangin,Monoket,Elantan	Others; Autophagy	Autophagy; Others
	Isosorbide Mononitrate (Corangin) 是一种硝酸盐血管扩张剂，扩张血管从而降低血压，可用于心绞痛。
T23854	Carbidine Carbidine dihydrochloride,Karbidin,Carbidin,Karbidine	Others	Others
	Carbidine (Carbidin) 是γ-carboline 的衍生物，一种非典型的抗精神病药物。它可以在体内和体外降低DA 对伏隔核突触体释放3H-DA 和酪氨酸羟化酶活性的抑制作用。
T25651	Lecimibide DuP128,DuP-128,DuP 128	Acyltransferase	Metabolism
	Lecimibide (DuP 128) 是一种有效且具有选择性的酰辅酶 A 胆固醇酰基转移酶(ACAT)抑制剂，可用于研究由于高脂带来的疾病。
T6551	Isosorbide Devicoran,Isobide,异山梨酯,异山梨醇,Hydronol,Dianhydro-D-glucitol,D-Isosorbide	Others	Others
	Isosorbide (Devicoran) 是一种血管舒张剂，也是一种高渗利尿剂，口服具有活性。可用于研究心力衰竭和心绞痛(胸痛)。
T16581	Progabide SL 76002,Halogabide,Gabren,Gabrene	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Progabide (SL 76002) 是一种 γ-氨基丁酸 (GABA) 受体激动剂。
T1479	Isosorbide dinitrate 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate	Others; NO Synthase	Immunology/Inflammation; Others
	Isosorbide dinitrate (Isordil) 是 NO 供体，可预防心肌梗死 (MI) 引起的左室重构及心功能退化。
T12858	Bidisomide SC40230	Others	Others
	Bidisomide (SC40230) (SC40230) 属于 I 类抗心律失常剂。
T126365	Nimbidiol
	Nimbidiol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126365，CAS号为 113332-25-5。
T15339	Foscarbidopa Carbidopa 4′-monophosphate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Foscarbidopa is a prodrug of Carbidopa. It acts as a dopamine receptor agonist.
T7911	Arbidol
	Umifenovir 是一种有效的口服活性广谱抗病毒药物，对许多包膜病毒和非包膜病毒具有活性。Umifenovir 既能抑制病毒繁殖又能调节炎性细胞因子的表达，可用作抗流感病毒剂 (anti-influenza virus)，并具有抗炎活性。Umifenovir 有效抑制病毒与宿主细胞的融合。 Umifenovir 是体外有效的 SARS-CoV-2的抑制剂。
T16372	Obidoxime dichloride	Others	Others
	Obidoxime dichloride, a selective oxime agent, effectively reactivates sarin-inhibited acetylcholinesterase (AChE) and mitigates the acute toxicity associated with sarin exposure. It is also utilized as an antidote for organophosphate nerve agent poisoning.
TP2465	PHYD protein, Arabidopsis Phyd gene product,Phyd protein
	PHYD protein, Arabidopsis belongs to the phytochrome apoprotein family in Arabidopsis.
T68770	Obidoxime thiocyanate
	Obidoxime thiocyanate is an AChE reactivator.
T130026	Bidwillon A
	Bidwillon A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T130026。
T68937	Carbidopa hydrochloride
	Carbidopa hydrochloride is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism of levodopa. This property is significant in that it allows a greater proportion of peripheral levodopa to cross the blood–brain barrier for central nervous system effect.
T13096	tBID	Others	Others
	tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 µM)
T124654	Methylpheophorbide A
	Methylpheophorbide A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124654。
T124867	Croalbidine
	Croalbidine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124867。
T33771	Obidoxime iodide
	Obidoxime iodide is an agricultural chemical.
T125974	Cannabidiol hydroxyquinone
	Cannabidiol hydroxyquinone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125974。
T33770	Obidoxime sulfate
	Obidoxime sulfate is an agricultural chemical.
T69108	Nebidrazine
	Nebidrazine is an alpha-adrenoceptor agonist.
T32323	Jurubidine
	Jurubidine is a type of cyclised aglycone from Jurubine.
T6396	(R)-(-)-Gossypol acetic acid (-)-Gossypol acetic acid,AT-101 (acetic acid),(R)-Gossypol acetic acid,AT101醋酸,AT101,AT101 acetate	BCL; Autophagy	Apoptosis; Autophagy
	(R)-(-)-Gossypol acetic acid (AT101 acetate) 是天然产物 Gossypol 的左旋异构体，与 Bcl-2、Bcl-xL 和 Mcl-1 结合，Ki 为 0.32 μM、0.48 μM 和 0.18 μM。
T36331	Z-AEVD-FMK Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone
	Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 &#181M, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]
T68653	YC-137
	YC-137 is a BCL-2 inhibitor, which selectively induces apoptosis of Bcl-2-overexpressing cells and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2.
T71267	GNF-8625
	GNE-8525 is a potent and selective pan-TRK inhibitor. GNE-8525 demonstrated potent antiproliferation activity with IC50 = 0.003 μM. In a tumor xenograft model derived from the KM12 cell line, GNE-8525 demonstrated in vivo antitumor efficacy when administered at ascending doses twice daily (bid) for 14 days in rats. Deregulated kinase activities of tropomyosin receptor kinase (TRK) family members have been shown to be associated with tumorigenesis and poor prognosis in a variety of cancer type...
T38269	Purfalcamine
	Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage[1][2]. Purfalcamine has low activity against Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3)[1]. Purfalcamine (225, 450 nM) has no effect on the parasitemia in the first 32 hours. After about 40 hours, paras...
T36296	BIO5192 hydrate
	BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels[1][2]. The combination of BIO5192 hydrate (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization[1].BIO5192 hydrate (30 mg/kg; s.c; bid; during days...
T37585	Ensartinib
	Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. The ability of Ensartinib (X-396) to inhibit the growth of different cancer cell lines harboring ALK fusions or point mutations is tested. Ensartinib is potent in H3122 lung cancer cells harboring EML4-ALK E13;A20 (IC50: 15nM). Ensartinib is also potent in H2228 lung cancer cells harboring EML4-ALK E6a/b; A20 (IC50: 45 nM). Furthermore, X-376 is potent in SUDHL-1 lymphoma cells harboring N...

化合物

Cat.No: T80226

Bid BH3 (80-99)

Cat.No: T80224

Bid BH3 (80-99), FAM labeled

Cat.No: T80225

Cat.No: T5827

Target: Apoptosis, Others, Mitochondrial Metabolism

Cat.No: T17314

Target: Others

Carbidopa monohydrate

Cat.No: T2148

Synonym: Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Isosorbide Mononitrate

Cat.No: T6863

Synonym: 单硝酸异山梨酯,Isosorbide-5-mononitrate,5-单硝酸异山梨酯,Imdur,Mononit,Corangin,Monoket,Elantan

Target: Others, Autophagy

Cat.No: T23854

Synonym: Carbidine dihydrochloride,Karbidin,Carbidin,Karbidine

Target: Others

Cat.No: T25651

Synonym: DuP128,DuP-128,DuP 128

Target: Acyltransferase

Cat.No: T6551

Synonym: Devicoran,Isobide,异山梨酯,异山梨醇,Hydronol,Dianhydro-D-glucitol,D-Isosorbide

Target: Others

Cat.No: T16581

Synonym: SL 76002,Halogabide,Gabren,Gabrene

Target: GABA Receptor

Isosorbide dinitrate

Cat.No: T1479

Synonym: 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate

Target: Others, NO Synthase

Cat.No: T12858

Synonym: SC40230

Target: Others

Cat.No: T126365

Cat.No: T15339

Synonym: Carbidopa 4′-monophosphate

Target: Dopamine Receptor

Cat.No: T7911

Obidoxime dichloride

Cat.No: T16372

Target: Others

PHYD protein, Arabidopsis

Cat.No: TP2465

Synonym: Phyd gene product,Phyd protein

Obidoxime thiocyanate

Cat.No: T68770

Cat.No: T130026

Carbidopa hydrochloride

Cat.No: T68937

Cat.No: T13096

Target: Others

Methylpheophorbide A

Cat.No: T124654

Cat.No: T124867

Obidoxime iodide

Cat.No: T33771

Cannabidiol hydroxyquinone

Cat.No: T125974

Obidoxime sulfate

Cat.No: T33770

Cat.No: T69108

Cat.No: T32323

(R)-(-)-Gossypol acetic acid

Cat.No: T6396

Synonym: (-)-Gossypol acetic acid,AT-101 (acetic acid),(R)-Gossypol acetic acid,AT101醋酸,AT101,AT101 acetate

Target: BCL, Autophagy

Cat.No: T36331

Synonym: Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone

Cat.No: T68653

Cat.No: T71267

Cat.No: T38269

BIO5192 hydrate

Cat.No: T36296

Cat.No: T37585

Cat. No.	Product Name	Target	Signaling Pathways
T6795	Carbidopa 卡比多巴,(S)-(-)-Carbidopa,Lodosyn	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂，是外周型脱羧酶抑制剂，抑制胰腺癌细胞和肿瘤生长，可用于帕金森病的研究。
TN6594	Bidenoside C	Others	Others
	Bidenoside C 是一种存在于 brazilian propolis，是首次从水蛭属草本植物中分离得到的中的黄酮类化合物。Bidenoside C 对癌细胞具有抗增殖活性。
T8162	Cannabidivarin Cannabidivarin,GWP-42006,GWP42006,GWP 42006	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Cannabidivarin (GWP42006) 是一种非拟精神病药大麻素。它具有缓解多种神经系统疾病 (包括癫痫和自闭症谱系障碍) 的研究潜力。
T36430	Pheophorbide a
	Pheophorbide a is a product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer. It has been reported to inhibit U87MG cells with an IC50 value of 2.8 μg/ml and demonstrates cytostatic activity specifically against glioblastoma cells without affecting normal cells. It also displays antiproliferative activity against melanoma, breast, and lung cancer cells in vitro at 100 μg/ml.
TN5652	Epicannabidiol hydrate
	Epicannabidiol hydrate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5652，CAS号为 139561-95-8。
T33492	Methyl pyropheophorbide-a MPPa (Methyl pyropheophorbide-a),NSC267052,Pyropheophorbidea,MPPa,NSC-267052,NSC 267052
	Pyropheophorbide-a methyl ester (MPPa) is a PDT photosensitizer, and is also a semisynthetic natural product derived from chlorophyll a. The absorption peak of MPPa in organic solvent and in cells was at 667 and 674 nm, respectively. 3-(4,5-Dimethylthiazo
TN4831	Procumbide
	Procumbide has anti-inflammatory activity.
TN5453	Bidwillol A
	Bidwillol A is a natural product from Erythrina arborescens.
TN4405	Lamalbid	Others	Others
	Lamalbid是一种天然产物，属于唇形科野芝麻属，其产品编号为 TN4405，CAS号为 52212-87-0。Lamalbid可用作对照参考。
T81812	Methyl pheophorbide a
	Methyl pheophorbide a，一种天然产物，源自叶绿素 a 的衍生物。
TN3994	Erythbidin A	Others	Others
	Erythbidin A is a natural product from Erythrina x bidwillii.
T82977	Arabidopyl alcohol
	Arabidopyl alcohol为一种从Betula pendula树皮中提取的天然化合物。
T81877	Mahanimbidine
	Mahanimbidine为一种萜类生物碱，可从Murraya koenigii Spreng的叶与茎皮中提取分离。
T19535	Pyropheophorbide-a Ppa,焦脱镁叶绿酸-ALPHA	Others	Others
	Pyropheophorbide-a (Ppa) 是一种可用于肿瘤光动力疗法 (PDT) 的光敏剂。
T82055	Ipalbidine
	Ipalbidine为自ipomoea Hardwickii Hemsl中提炼的生物碱，显示出剂量依赖性镇痛效果。
T2730	Gossypol (acetic acid) (±)-Gossypol-acetic acid,Pogosin,AT101,醋酸棉酚,乙酸棉子酚,Gossypol acetic acid	BCL	Apoptosis
	Gossypol acetic acid (AT101) 是一种从棉籽中分离出来的多酚天然产物，分别与 Bcl-xL 蛋白和 Bcl-2蛋白结合，Ki 值分别为 0.5-0.6 μM 和 0.2-0.3 mM。
T66078	Cardamonin
	Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 values were 16.22 μM(CNE-1), 14.34 μM (CNE-2), 16.50 μM (HONE-1), and 68.12 μM (SUNE-1). Moreover, the expression level of the proapoptotic effector protein Bax and Bid was also markedly increased after treatment with cardamonin（15μM） in CNE-2 cells.In vivo, cardamonin (25 mg/kg ...

天然产物

Cat.No: T6795

Synonym: 卡比多巴,(S)-(-)-Carbidopa,Lodosyn

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Cat.No: TN6594

Target: Others

Cat.No: T8162

Synonym: Cannabidivarin,GWP-42006,GWP42006,GWP 42006

Target: GABA Receptor

Cat.No: T36430

Epicannabidiol hydrate

Cat.No: TN5652

Methyl pyropheophorbide-a

Cat.No: T33492

Synonym: MPPa (Methyl pyropheophorbide-a),NSC267052,Pyropheophorbidea,MPPa,NSC-267052,NSC 267052

Cat.No: TN4831

Cat.No: TN5453

Cat.No: TN4405

Target: Others

Methyl pheophorbide a

Cat.No: T81812

Cat.No: TN3994

Target: Others

Arabidopyl alcohol

Cat.No: T82977

Cat.No: T81877

Pyropheophorbide-a

Cat.No: T19535

Synonym: Ppa,焦脱镁叶绿酸-ALPHA

Target: Others

Cat.No: T82055

Gossypol (acetic acid)

Cat.No: T2730

Synonym: (±)-Gossypol-acetic acid,Pogosin,AT101,醋酸棉酚,乙酸棉子酚,Gossypol acetic acid

Target: BCL

Cat.No: T66078

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