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Search Results for " alr "

Targets Recommended: Reductase

20

抑制剂 & 化合物

2

天然产物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T77523	ALR2-IN-1	Reductase	Endocrinology/Hormones; Metabolism
	ALR2-IN-1 是一种有效的且具有选择性的 ALR2 抑制剂，IC50值为1.42 μM。ALR2-IN-1 具有抗糖和抗氧化活性，可用于研究糖尿病并发症。
T2013	Ponalrestat	Reductase	Endocrinology/Hormones; Metabolism
	Ponalrestat 是一种口服有效的，选择性的和非竞争性的醛糖还原酶抑制剂，对 ALR2选择性选择性较高，Ki 为 7.7 nM，对 ALR1 的选择性较弱，Ki 为 60 μM。Ponalrestat 抑制葡萄糖向山梨糖醇的转化。
T73305	ALR2-IN-3
	ALR2-IN-2 是一种有效的醛糖还原酶 (ALR2) 抑制剂，抑制大鼠 ALR2和 ALR1的 IC50值分别为为 22 nM 和 116 nM。ALR2-IN-2 可用于研究糖尿病并发症。
T73304	ALR2-IN-2
	ALR2-IN-2, 作为一种高效的醛糖还原酶 (ALR2) 抑制剂，对大鼠ALR2的IC50值为27 nM，对ALR1的IC50值为228 nM。此化合物适用于糖尿病并发症的研究。
T62456	ALR1/2-IN-1
	ALR1/2-IN-1 (Compound 6e) 是一种醛还原酶 (ALR1) (IC50: 3.26 μM) 和醛糖还原酶 (ALR2) (IC50: 3.06 μM) 抑制剂，具有抗癌作用。
T5195	Alrestatin 阿瑞司他丁,AY-22284	Reductase	Endocrinology/Hormones; Metabolism
	Alrestatin (AY-22284) 是醛糖还原酶的特异性抑制剂，能够在体外减弱大鼠血管平滑肌中葡萄糖诱导的血管紧张素 II 的产生。
T7604	Valrubicin Valstar,AD-32,戊柔比星	Antibiotic; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology
	Valrubicin (AD-32) 是一种具有抗炎和抗肿瘤作用的化疗剂，能够抑制 TPA 和 PDBu 诱导的 PKC 活化，IC50值分别为 0.85 和 1.25 μM。
T3562	Valrocemide TV1901,N-丙戊酰基甘氨酰胺,N-Valproylglycinamide,丙戊塞胺	Others	Others
	Valrocemide (TV1901) 是有前景的抗癫痫候选药物，具有广泛的抗惊厥特性。
T33389	Minalrestat ARI509,WAY-121509,WAY121509,WAYARI-509,ARI-509,WAY-ARI-509	Reductase	Endocrinology/Hormones; Metabolism
	Minalrestat(ARI-509) 是一种具有口服活性和有效性的醛糖还原酶 (aldose reductase) 抑制剂，可用于研究糖尿病患者微血管反应性受损。
T14303	Alrizomadlin APG-115,AA-115	Mdm2	Apoptosis
	Alrizomadlin (APG-115) 是一种具有口服活性的 MDM2 抑制剂，IC50 为 3.8 nM，Ki 分别为 1 nM[1]。 Alrizomadlin 阻断 MDM2 和 p53 的相互作用，并以 p53 依赖性方式诱导细胞周期停滞和细胞凋亡。
T1832	Walrycin B	Antibacterial; Antibiotic	Microbiology/Virology
	Walrycin B 是一种能特异地靶向WalR 应答调节子的新型抗菌素。
T1458	Epalrestat ONO2235,依帕斯他,依帕司他	Reductase	Endocrinology/Hormones; Metabolism
	Epalrestat (ONO2235) 是醛糖还原酶抑制剂，在长期治疗中具有良好的耐受性。它可以有效改善糖尿病神经病变的相关症状并延缓疾病的进展，特别是在微血管病变有限且血糖控制良好的患者中。
T26601	ALRT 1550 LG-1550,LGD-1550,ALRT-1550,LG1550,ALRT-550,ALRT1550
	ALRT 1550, a retinoic acid agent (RAR) agonist, is used potentially for the treatment of cervical carcinoma.
T83135	Alrefimotide hTERT (660–689)
	Alrefimotide为一种衍生自hTERT的免疫肽，其序列为ALFSVLNYERARRPGLLGASVLGLDDIHRA，主要应用于癌症免疫治痗研究。
T5195L	Alrestatin Sodium AY 22284A,AY-22284A,Alrestatine sodium,AY22284A
	Alrestatin is a specific inhibitor of the aldose reductase enzyme.
T76252L	WLSEAGPVVTVRALRGTGSW TFA
	WLSEAGPVVTVTVRALGTGSW TFA 为心肌细胞特异性肽。该化合物通过表达外泌体，提高心肌细胞的特定摄取能力，降低心肌细胞凋亡率，并在体内心肌内注射后提升心脏潴留能力。
T70610	ALRN-6924
	ALRN-6924 is a novel dual MDM4 and MDM2 inhibitor.
T3572	NSC 15364 1,3-Bis(4-aminophenyl)urea,NSC15364	Apoptosis; Others; VDAC	Apoptosis; Membrane transporter/Ion channel; Others
	NSC 15364 (1,3-Bis(4-aminophenyl)urea) 是一种 VDAC1寡聚化和细胞凋亡抑制剂。
T60186	(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	MitoBloCK-6 是一种有效的 Erv1/ALR 抑制剂，IC50 分别为 900 nM 和 700 nM。MitoBloCK-6 还抑制 Erv2 (IC50=1.4 μM)。MitoBloCK-6 可通过细胞色素 c 的释放诱导 hESCs 细胞凋亡。
T60143	MitoBloCK-6	Apoptosis	Apoptosis
	MitoBloCK-6 是一种有效的Erv1/ALR 抑制剂，IC50分别为 900 nM 和 700 nM。MitoBloCK-6 还抑制Erv2，IC50值为1.4 μM。MitoBloCK-6 可通过释放细胞色素 c 诱导 hESCs 细胞凋亡。

化合物

Cat.No: T77523

Target: Reductase

Cat.No: T2013

Target: Reductase

Cat.No: T73305

Cat.No: T73304

Cat.No: T62456

Cat.No: T5195

Synonym: 阿瑞司他丁,AY-22284

Target: Reductase

Cat.No: T7604

Synonym: Valstar,AD-32,戊柔比星

Target: Antibiotic, PKC

Cat.No: T3562

Synonym: TV1901,N-丙戊酰基甘氨酰胺,N-Valproylglycinamide,丙戊塞胺

Target: Others

Cat.No: T33389

Synonym: ARI509,WAY-121509,WAY121509,WAYARI-509,ARI-509,WAY-ARI-509

Target: Reductase

Cat.No: T14303

Synonym: APG-115,AA-115

Target: Mdm2

Cat.No: T1832

Target: Antibacterial, Antibiotic

Cat.No: T1458

Synonym: ONO2235,依帕斯他,依帕司他

Target: Reductase

Cat.No: T26601

Synonym: LG-1550,LGD-1550,ALRT-1550,LG1550,ALRT-550,ALRT1550

Cat.No: T83135

Synonym: hTERT (660–689)

Alrestatin Sodium

Cat.No: T5195L

Synonym: AY 22284A,AY-22284A,Alrestatine sodium,AY22284A

WLSEAGPVVTVRALRGTGSW TFA

Cat.No: T76252L

Cat.No: T70610

Cat.No: T3572

Synonym: 1,3-Bis(4-aminophenyl)urea,NSC15364

Target: Apoptosis, Others, VDAC

(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

Cat.No: T60186

Target: Discoidin Domain Receptor (DDR)

Cat.No: T60143

Target: Apoptosis

Cat. No.	Product Name	Target	Signaling Pathways
TN2271	Thalrugosaminine	Antifection	Microbiology/Virology
	Thalrugosaminine shows promising antibacterial activity with MIC values of 64-128ug/ml and Staphylococcus species is the most sensitive strains. Thalrugosaminine possesses hypotensive activity in rabbits and is active against Mycobacterium smegmatis.
TN5140	Thalrugosidine	Others	Others
	Thalrugosidine is a natural product from Thalictrum foliolosum DC.

天然产物

Thalrugosaminine

Cat.No: TN2271

Target: Antifection

Cat.No: TN5140

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00368	ALR Protein, Human, Recombinant (His) HPO,ERV1,HERV1,ALR,HSS,HPO2,growth factor, augmente...	Human	HEK293 Cells
	Alterations in GFER gene have been associated with progressive mitochondrial myopathy, congenital cataracts, hearing loss, developmental delay, lactic acidosis and respiratory chain deficiency in 3 siblings born to consanguineous Moroccan parents by homozygosity mapping and candidate gene approach. Using homozygosity mapping, we discovered that a mutation in the GFER gene causes an infantile mitochondrial disorder.
TMPJ-01020	GFER Protein, Human, Recombinant (His) Augmenter of liver regeneration,FAD-linked sulfhydryl oxidas...	Human	E. coli
	GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ER...
TMPY-02461	AKR1A1 Protein, Human, Recombinant (His) DD3,ALDR1,HEL-S-6,aldo-keto reductase family 1, member A1 (a...	Human	E. coli
	Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase. Aldehyde reductase has wide substrate specificities for carbonyl compounds. These enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Aldehyde reductase possess a structure with a beta-alpha-beta fo...
TMPY-02438	AKR1B1 Protein, Human, Recombinant (His) ALDR1,AR,ADR,aldo-keto reductase family 1, member B1 (aldose...	Human	E. coli
	Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the c...
TMPH-03065	Alr2278 Protein, Nostoc sp., Recombinant (His & MBP)	Nostoc	Baculovirus Insect Cells
	Alr2278 Protein, Nostoc sp., Recombinant (His & MBP) is expressed in Baculovirus.
TMPH-03105	Calreticulin Protein, Pig, Recombinant (His) Endoplasmic reticulum resident protein 60,CRP55,CRT,Calr...	Sus scrofa (Pig)	P. pastoris (Yeast)
	Calreticulin Protein, Pig, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is P28491.
TMPY-06327	Calreticulin Protein, Human, Recombinant HEL-S-99n,calreticulin,cC1qR,CRT,RO,SSA	Human	HEK293 Cells
	Calreticulin Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.99 kDa and the accession number is P27797.
TMPH-02558	Calreticulin Protein, Mouse, Recombinant (His) ERp60,CRP55,CRT,CALR,Calregulin,Calr	Mouse	P. pastoris (Yeast)
	Calreticulin Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 48.3 kDa and the accession number is P14211.
TMPH-00436	Calreticulin Protein, Cricetulus griseus, Recombinant (His) ERp60,Calreticulin,Calregulin,CRT,CRP55,HA...	Chinese hamster	P. pastoris (Yeast)
	Calreticulin Protein, Cricetulus griseus, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 48.1 kDa and the accession number is Q8K3H7.
TMPH-02559	Calreticulin Protein, Mouse, Recombinant (GST) ERp60,Calreticulin,Endoplasmic reticulum resident p...	Mouse	E. coli
	Calreticulin Protein, Mouse, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 73.3 kDa and the accession number is P14211.
TMPY-03258	Calreticulin Protein, Human, Recombinant (hFc) RO,cC1qR,HEL-S-99n,CRT,calreticulin,SSA	Human	HEK293 Cells
	Calreticulin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73 kDa and the accession number is P27797.
TMPY-03259	Calreticulin Protein, Human, Recombinant (His) HEL-S-99n,cC1qR,SSA,CRT,RO,calreticulin	Human	HEK293 Cells
	Calreticulin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.4 kDa and the accession number is P27797.

重组蛋白

ALR Protein, Human, Recombinant (His)

Cat.No: TMPY-00368

Species: Human

Expression System: HEK293 Cells

GFER Protein, Human, Recombinant (His)

Cat.No: TMPJ-01020

Species: Human

Expression System: E. coli

AKR1A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02461

Species: Human

Expression System: E. coli

AKR1B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02438

Species: Human

Expression System: E. coli

Alr2278 Protein, Nostoc sp., Recombinant (His & MBP)

Cat.No: TMPH-03065

Species: Nostoc

Expression System: Baculovirus Insect Cells

Calreticulin Protein, Pig, Recombinant (His)

Cat.No: TMPH-03105

Species: Sus scrofa (Pig)

Expression System: P. pastoris (Yeast)

Calreticulin Protein, Human, Recombinant

Cat.No: TMPY-06327

Species: Human

Expression System: HEK293 Cells

Calreticulin Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02558

Species: Mouse

Expression System: P. pastoris (Yeast)

Calreticulin Protein, Cricetulus griseus, Recombinant (His)

Cat.No: TMPH-00436

Species: Chinese hamster

Expression System: P. pastoris (Yeast)

Calreticulin Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02559

Species: Mouse

Expression System: E. coli

Calreticulin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03258

Species: Human

Expression System: HEK293 Cells

Calreticulin Protein, Human, Recombinant (His)

Cat.No: TMPY-03259

Species: Human

Expression System: HEK293 Cells

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