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Cat. No. | Product Name | Target | Signaling Pathways |
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T26728 |
Aziridyl benzoquinone
A-139,A139,NSC-17262 |
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Aziridyl benzoquinone, an antineoplastic agent, has been studied as a mutagen and as a carcinogenic agent. | |||
TP1312L |
[SER140]-PLP(139-151) acetate
[SER140]-PLP(139-151) acetate (122018-58-0 Free base) |
Others | Others |
[SER140]-PLP(139-151) acetate 是来自髓鞘蛋白脂蛋白 (PLP) 的肽片段。 | |||
T27252 |
ELB-139
ELB139 |
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ELB-139 is a GABA A receptor agonist. ELB139 increases 5-HT in the striatum and prefrontal cortex of rats. | |||
T2299 |
BMS-833923
XL-139 |
Apoptosis; Hedgehog/Smoothened; Smo | Apoptosis; GPCR/G Protein; Stem Cells |
BMS-833923 (XL-139) 是一种口服生物可利用的 Smoothened 拮抗剂,以剂量依赖性方式抑制 BODIPY cyclopamine 与 SMO 的结合,IC50为21 nM。 | |||
T6291 |
WZ4003
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AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
WZ4003 是一种高度特异性 NUAK 激酶的有效抑制剂,能够抑制 NUAK1 和 NUAK2 的活性,IC50值分别为 20 和 100 nM。 | |||
T64674 | Plp(139-151) trifluoroacetate | ||
Plp(139-151) trifluoroacetate 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64674。 | |||
TP1402 |
[SER140]-PLP(139-151) TFA (122018-58-0 free base)
[SER140]-PLP(139-151) TFA |
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[SER140]-PLP(139-151) (TFA) is a polypeptide fragment of the myelin lipid protein. | |||
T76649 |
Osteostatin (human)
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Osteostatin (human),一种甲状旁腺激素相关蛋白(PTHrP) 107-139片段,可在骨缺损动物模型中促进骨修复并在炎症性关节炎中防止骨侵蚀。 | |||
T76934 |
Brazikumab
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Brazikumab (AMG 139) 是一种人IgG2单克隆抗体,可选择性结合IL-23的 p19 亚基,对人IL-23的KD 值为 0.138 nM 的。Brazikumab 可用于克罗恩病的研究。 | |||
TP1312 |
[SER140]-PLP(139-151)
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[SER140]-PLP(139-151) is a polypeptide fragment of the lipid protein of myelin. | |||
T72543 |
BOLD-100 free base
NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base |
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BOLD-100 (NKP-1339; IT-139) free base 是一款钌基抗癌药物。作为GRP78应激诱导上调的抑制剂,它破坏内质网(ER)的稳态,从而诱发ER应激和未折叠蛋白反应(UPR)。此外,BOLD-100 free base 干预了内质网应激反应、溶酶体动力学以及细胞自噬(autophagy)间的复杂交互作用。 | |||
T83690 |
[Leu144, Arg147]-PLP (139-151) TFA
[Leu144, Arg147] Proteolipid Peptide (139-151),H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH |
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[Leu144,Arg147]-PLP (139-151)是髓鞘脂蛋白(PLP)的一种突变肽段,包含位于144和147位置的色氨酸到亮氨酸以及组氨酸到精氨酸的替换。使用[Leu144, Arg147]-PLP (139-151)(50 µg)乳化于完全弗氏佐剂(CFA)免疫后,能增加小鼠脾脏中的IL-4水平。它在体外抑制Th1细胞激活,但在体内不抑制,其中它诱导调节性T细胞的产生。用[Leu144, Arg147]-PLP (139-151)预免疫可以延迟由脑炎肽PLP (178-191)、髓磷脂少突细胞蛋白(MOG) (92-106)或髓鞘基础蛋白(MBP)在小鼠中诱导的实验性自身免疫性脑炎(EAE)的发病。 | |||
T36634 |
ZQ 16
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Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro. Liu et al (2016) Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 7 579 PMID:27326330 |Zhang et al (2016) Discovery and characte... | |||
T82313 |
GK718
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HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
GK718为一HDAC1/3特异性抑制剂,IC50值分别为259 nM和139 nM。该化合物能提升细胞内乙酰化组蛋白H3含量,并能够抑制Bleomycin所诱导的小鼠肺纤维化现象。 | |||
T81439 |
PLP (178-191)
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PLP (178-191) 是具有生物活性的肽段,为蛋白脂质蛋白(PLP)中的一部分,范围涵盖氨基酸178至191。在SJL小鼠中,PLP作为免疫显性致脑炎表位,是两个主要致脑炎表位之一。与另一致脑炎肽段PLP(139-151)相比,PLP (178-191)可导致更早的疾病发作时间,尽管在发病率、疾病严重性和组织学特征方面与之不具区分性。 | |||
T78780 |
Anticancer agent 139
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Anticanceragent 139(Compound 6h)展现了针对多种癌细胞株的抗癌效能。该化合物能够与Tubulin的Lys352残基发生π-阳离子相互作用。在对SNB-19、OVCAR-8和NCI-H460细胞株的测试中,Anticanceragent 139展现出较高的生长抑制率(PGI),数值分别为86.61、85.26和75.99。同时,该化合物对于HOP-62、SNB-75、ACHN、NCI/ADR-RES、786-O、A549/ATCC、HCT-116以及MDA-MB-231细胞株亦表现出中等的生长抑制作用,其PGI值分别为67.55、65.46、59.09、59.02、57.88、56.88、56.53和56.4、51.88。 | |||
TMIH-0523 |
Sodium cyclamate-d4
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Sodium cyclamate-d4 是 Sodium cyclamate 的氘代化合物。Sodium cyclamate 的 CAS 号为 139-05-9。Cyclamic acid sodium是一种碳酸酐酶抑制剂,是食品和药品中使用最广泛的人工甜味剂之一。Cyclamic acid sodium在最大电休克惊厥发作模型显示出中等的抗惊厥活性。Cyclamic acid sodium可用于研究癌症。 | |||
T36662 |
Imidafenacin Metabolite M4
Imidafenacin Metabolite M4 |
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Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. 1.Kanayama, N., Kanari, C., Masuda, Y., et al.Drug-drug interactions in the metabolism of imidafenacin: Role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymesXenobiotica37(2)139-154(2007) | |||
T36176 |
AMK (hydrochloride)
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AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T83245 |
7-Desmethylmicrocystin-LR
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7-Desmethylmicrocystin-LR为有毒七肽类化合物,可自无菌铜绿微囊藻菌株(K-139)中提取。 |