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DC-SIGN Protein, Human, Recombinant (hFc)

产品编号 TMPY-00772

别名: DC-SIGN, CD209 molecule, CDSIGN, CLEC4L, CD209, MGC129965, DC-SIGN1

DC-SIGN Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.8 kDa and the accession number is Q9NNX6-1.

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DC-SIGN Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,130		现货
200 μg	￥ 5,540		5日内发货
500 μg	￥ 11,720		5日内发货

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生物活性	Testing in progress
产品描述	DC-SIGN Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.8 kDa and the accession number is Q9NNX6-1.

种属	Human
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	Q9NNX6-1
别名	DC-SIGN, CD209 molecule, CDSIGN, CLEC4L, CD209, MGC129965, DC-SIGN1
蛋白构建	The N-terminally truncated extracellular domain (Lys 62-Ala 404) of Human DC-SIGN (NP_066978.1) was expressed with the fused Fc region of Human IgG1 at the N-terminus.
蛋白纯度	> 97 % as determined by SDS-PAGE
分子量	65.8 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has an important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates the capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Geijtenbeek TB, et al. (2002) DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukoc Biol. 71(6): 921-31. 2. Masso M. (2003) DC-SIGN points the way to a novel mechanism for HIV-1 transmission. MedGenMed. 5(2): 2. 3. Zhou T, et al. (2006) DC-SIGN and immunoregulation. Cell Mol Immunol. 3(4): 279-83.

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Keywords

DC-SIGN Protein, Human, Recombinant (hFc) CD 209 DC-SIGN CD209 molecule CDSIGN CLEC4L CD209 MGC129965 CD-209 DC-SIGN1 MGC 129965 MGC-129965 recombinant recombinant-proteins proteins protein

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