4
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19613 |
(3β,20E)-24-Norchola-5,20(22)-diene-3,23-diol
|
Others | Others |
(3β,20E)-24-Norchola-5,20(22)-diene-3,23-diol is a steroid-based allylic alcohol. | |||
T7358 |
YK11
(17ALPHA,20E)-17,20-[(1-甲氧基乙亚基)二(氧基)]-3-氧代-19-去甲孕甾-4,20-二烯-21-羧酸甲酯 |
Androgen Receptor | Endocrinology/Hormones |
YK11 是雄激素受体部分激动剂,当使用浓度为 0.1 μM 时,可激活过表达雄激素受体的 HEK293 细胞中的雄激素受体转录活性,具有成骨活性。 | |||
T36397 |
TAN 420E
|
||
TAN 420E is a bacterial metabolite originally isolated from Streptomyces. It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 1.3 μM) and reduces thiobarbituric acid reactive substances (TBARS) in rat liver microsomes by 72% when used at a concentration of 100 μg/ml. TAN 420E is active against B. brevis, B. cereus, M. flavus, and S. aureus (MICs = 50-100 μg/ml). It is cytotoxic to P388 and KB lymphocytic leukemia cells (EC50s = 0.022 and 0.3 μg/ml, respectively). | |||
T61339 | LDHA/PDKs-IN-1 | ||
LDHA/PDKs-IN-1 (compound 20e) is a highly effective dual inhibitor of PDKs and LDHA, displaying IC50 values of 0.8 μM and 0.15 μM, respectively. It significantly suppresses A549 cell proliferation (EC50 = 13.2 μM), reduces lactate formation, and enhances oxygen consumption. This compound holds great promise for cancer research [1]. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN3910 |
Ecdysone
|
Apoptosis; ATPase; Glucocorticoid Receptor; Potassium Channel; Sodium Channel; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; Membrane transporter/Ion channel; Metabolism |
Ecdysone 是存在于昆虫和草药中的主要类固醇激素,可以激活盐皮质激素受体并诱导细胞凋亡。Ecdysone 的活性代谢物 20-羟基蜕皮激素在协调发育过渡和体内稳态睡眠调节中起重要作用。 | |||
T2881 |
Crustecdysone
Commisterone,B-ecdysone,Commisterone,20-Hydroxyecdysone,Ecdysterone,B-ecdysone,β-蜕皮甾酮,Hydroxyecdysone,羟基蜕皮激素 |
Others; Caspase; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Metabolism; Others; Proteases/Proteasome |
Crustecdysone (Hydroxyecdysone) 是来源于露水草的一种蜕皮激素,可调节昆虫的蜕皮或蜕皮过程。它是 Ecdysone 的活性代谢物,通过 20E 核受体复合物 EcR-USP 抑制半胱天冬酶活性并诱导自噬,在心血管系统中具有调节或保护作用。 | |||
TN2114 |
Pseudoginsenoside Rh2
拟人参皂苷RH2,拟人参皂苷 Rh2 |
ERK; Raf; p53 | Apoptosis; MAPK |
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathway. (20Z) -Pseudoginsenoside Rh2 and (20E)-Pseudoginsenoside Rh2 have antioxidative activity. |