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Search Results for " 2'-deoxyuridine "

35

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T17341	5-Ethynyl-2'-deoxyuridine	Others; PROTAC Linker	Others; PROTAC
	5-Ethynyl-2'-deoxyuridine 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 的合成分子。它是一种胸腺嘧啶核苷类似物，在细胞增殖时能够插入正在复制的 DNA 分子中， EdU 与染料的共轭反应可以进行高效快速的细胞增殖检测分析。
T19151	5-Chloro-2'-deoxyuridine 5-Chlorodeoxyuridine,5-氯-2-脱氧尿嘧啶核苷,CldU	Others	Others
	5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) 是胸腺嘧啶的类似物，可用于次氯酸对 DNA 和 DNA 前体的破坏作用的研究。
T67291	2′,2′-Difluorodeoxyuridine dFdU,2',2'-Difluoro-2'-deoxyuridine	Drug Metabolite	Metabolism
	2′,2′-Difluorodeoxyuridine (dFdU) 是 Gemcitabine 的主要代谢产物。2′,2′-Difluorodeoxyuridine 具有抗癌和抗肿瘤活性，在低氧条件下的显示出放射增敏作用，可用于研究胰腺癌。
T19152	5-OHdU 5-羟基-2'-脱氧尿苷	Nucleoside Antimetabolite/Analog; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	5-OHdU (5-OHdU) 是 2'-Deoxycytidine 的主要氧化产物，可在体外掺入 DNA。
T10068	2'-Azido-2'-deoxyuridine N3dUrd	Others	Others
	2'-Azido-2'-deoxyuridine (N3dUrd) is a ribonucleotide reductase inhibitor with anti-cancer activity.
T39912	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine 5'-O-DMT-dU,保护-2'-脱氧尿苷	Others	Others
	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) 是大肠杆菌 dUTP 核苷酸水解酶的竞争性抑制剂，Ki 高于 1000 μM。它通过合成核苷亚磷酰胺嵌段用于机器辅助的 DNA 合成。
T0863	Idoxuridine IDU,碘苷,SKF 14287,5-Iodo-2′-deoxyuridine,NSC 39661,5-IUdR,Dendrid	Antifection; HSV	Microbiology/Virology
	Idoxuridine (Dendrid) 是一种抑制病毒 DNA 合成的脱氧尿苷类似物，用作抗病毒剂。
T6794	5-BrdU 溴脲苷,BUdR,5-溴脱氧尿嘧啶核苷,Broxuridine,5-bromo-2'-deoxyuridine,Bromodeoxyuridine,BRDU	Nucleoside Antimetabolite/Analog; Others	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	5-BrdU (Broxuridine) 是一种核苷类似物，用于检测增殖细胞并与胸苷竞争掺入 DNA。
TNU1568	2-Deoxyuridine
	Nucleoside Derivatives - 2-Deoxy uridines
T41104	dUTP sodium 2'-Deoxyuridine-5'-triphosphate sodium salt
	dUTP sodium is used for PCR.
TNU0073	2’-Chloro-2’-deoxyuridine
	Halo-nucleoside
TNU0742	2’-Bromo-2’-deoxyuridine
	Nucleoside Derivatives - 2’-Modified nucleoside; Halo-nucleoside
TNU1564	2-Deoxy-2’-deoxyuridine
	Nucleoside Derivatives - 2-Deoxy uridines
T19149	5-BrdUTP sodium salt 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt	Others	Others
	5-BrdUTP sodium salt is a TdT substrate that can be used to label the DNA double-strand breaks.
TNU1280	5-(2-Hyroxyethyl)-2’-deoxyuridine
	Nucleoside Derivatives - 5-Modified pyrimidine nucleosides
TNU1188	N3-Methyl-2’-deoxyuridine
	Nucleoside Derivatives - N-Methylated nucleosides
TNU1518	5’-O-Triphenylmethyl-2’-deoxyuridine
	Nucleoside Derivatives - Protected nucleosides with NH2/OH open
TNU0621	5-Bromo-2’-fluoro-2’-deoxyuridine
	Nucleoside, fluoro-modified nucleoside, halo-nucleoside
TNU1634	3’-O-Acetyl-2’-deoxyuridine
	3’-O-Acetyl-2’-deoxyuridine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TNU1634，CAS号为 23197-88-8。
TNU1243	5-Amino-2’-deoxyuridine hydrochloride
	Nucleoside Derivatives - 5-Modified pyrimidine nucleosides; Amino nucleosides
TNU0647	5’-O-DMTr-5-Iodo-2’-deoxyuridine
	Halo-nucleoside
T75199	5-(2-Hydroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine
	5-(2-Hydroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物，主要通过抑制 DNA 合成和诱导细胞凋亡 (apoptosis) 机制，靶向治疗惰性淋巴系统恶性肿瘤。
TNU1279	5-(2-Hyroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine
	Nucleoside Derivatives - 5-Modified pyrimidine nucleosides; Scaffolds and Templates
TNU1514	5’-O-DMTr-3’-deoxyuridine 2’-CED phosphoramidite
	Nucleoside Derivatives –3’-Deoxy nucleosides；Nucleoside Phosphoramidites
TNU1111	α-Azidothymidine
	Nucleoside Derivatives - Azido-nucleosides, 5-Modified pyrimidine nucleosides
T83833	Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) sodium Rp-dUTP-α-S
	Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) (Rp-dUTP-α-S) 是含硫核苷酸 dUTP-α-S 的同分异构体，也是嘌呤P2Y2受体的激动剂。在表达P2Y2受体的1321N1星形胶质瘤细胞中，该化合物特异性诱导肌醇磷酸积累（EC50 = 12.5 µM），相较于表达P2Y4的1321N1细胞，在10 µM浓度下效果更显著。
TNU1186	2’,3’-Bis(O-t-butyldimethylsilyl)-4’,5’-Didehydro-5’-deoxyuridine
	Nucleoside Derivatives - 5’-Modified nucleosides, Didehydro-nucleosides
TNU0932	2’-O-Acetyl-3’-azido-5’-O-(p-Toluoyl))-3’-deoxyuridine
	Nucleoside Derivatives - 3’-Modified nucleoside, Azido-nucleosides
T2169	Zebularine NSC309132,4-Deoxyuridine	DNA Methyltransferase; Autophagy	Autophagy; Chromatin/Epigenetic
	Zebularine (4-Deoxyuridine) 是一种 DNA 甲基化抑制剂，还抑制胞苷脱氨酶。它通过以共价水合物的形式与活性大小结合，充当胞苷脱氨酶的过渡态类似物抑制剂。
T16785	Ropidoxuridine IPdR	Others	Others
	Ropidoxuridine (IPdR) 是一种新型的、可口服的卤化胸苷类似物，有望成为人类肿瘤的增敏剂。Ropidoxuridine 是一种可口服且具有生物可利用的IUdR(5-碘-2'-脱氧尿苷)前药。
T1408	Capecitabine Xeloda,卡培他滨,Capecitibine,Capiibine,RO 09-1978	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Capecitabine (Capecitibine) 是一种可口服的前药，可由胸苷磷酸化酶催化转变为其活性代谢物 Fluorouracil。
T24881	Thymectacin NB 1011,NB-1011,NB1011
	Thymectacin is a small molecule phosphoramidite derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine with potential antineoplastic activity.
T61492	Idoxuridine hydrate
	Idoxuridine hydrate (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is a competitive inhibitor of phosphorylases. As an iodinated thymidine analogue, it effectively inhibits DNA polymerase and hinders viral replication, making it useful in the treatment of viral eye infections such as herpes simplex keratitis. Against feline herpesvirus, Idoxuridine has been found to have an IC50 value of 4.3 μM [1].
T75341	Biotin-16-dUTP trisodium
	Biotin-16-dUTP trisodium（Biotin-16-deoxyuridine-5'-triphosphate trisodium）可以通过酶促方式掺入DNA/cDNA中，作为其天然对应物dTTP的替代品。这种化合物主要用于生产用于多种检测应用的生物素化DNA探针。储存条件需避光。
T35439	(E)-5-(2-Bromovinyl)uracil
	(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

化合物

5-Ethynyl-2'-deoxyuridine

Cat.No: T17341

Target: Others, PROTAC Linker

5-Chloro-2'-deoxyuridine

Cat.No: T19151

Synonym: 5-Chlorodeoxyuridine,5-氯-2-脱氧尿嘧啶核苷,CldU

Target: Others

2′,2′-Difluorodeoxyuridine

Cat.No: T67291

Synonym: dFdU,2',2'-Difluoro-2'-deoxyuridine

Target: Drug Metabolite

Cat.No: T19152

Synonym: 5-羟基-2'-脱氧尿苷

Target: Nucleoside Antimetabolite/Analog, Endogenous Metabolite

2'-Azido-2'-deoxyuridine

Cat.No: T10068

Synonym: N3dUrd

Target: Others

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

Cat.No: T39912

Synonym: 5'-O-DMT-dU,保护-2'-脱氧尿苷

Target: Others

Cat.No: T0863

Synonym: IDU,碘苷,SKF 14287,5-Iodo-2′-deoxyuridine,NSC 39661,5-IUdR,Dendrid

Target: Antifection, HSV

Cat.No: T6794

Synonym: 溴脲苷,BUdR,5-溴脱氧尿嘧啶核苷,Broxuridine,5-bromo-2'-deoxyuridine,Bromodeoxyuridine,BRDU

Target: Nucleoside Antimetabolite/Analog, Others

2-Deoxyuridine

Cat.No: TNU1568

Cat.No: T41104

Synonym: 2'-Deoxyuridine-5'-triphosphate sodium salt

2’-Chloro-2’-deoxyuridine

Cat.No: TNU0073

2’-Bromo-2’-deoxyuridine

Cat.No: TNU0742

2-Deoxy-2’-deoxyuridine

Cat.No: TNU1564

5-BrdUTP sodium salt

Cat.No: T19149

Synonym: 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt

Target: Others

5-(2-Hyroxyethyl)-2’-deoxyuridine

Cat.No: TNU1280

N3-Methyl-2’-deoxyuridine

Cat.No: TNU1188

5’-O-Triphenylmethyl-2’-deoxyuridine

Cat.No: TNU1518

5-Bromo-2’-fluoro-2’-deoxyuridine

Cat.No: TNU0621

3’-O-Acetyl-2’-deoxyuridine

Cat.No: TNU1634

5-Amino-2’-deoxyuridine hydrochloride

Cat.No: TNU1243

5’-O-DMTr-5-Iodo-2’-deoxyuridine

Cat.No: TNU0647

5-(2-Hydroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine

Cat.No: T75199

5-(2-Hyroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine

Cat.No: TNU1279

5’-O-DMTr-3’-deoxyuridine 2’-CED phosphoramidite

Cat.No: TNU1514

α-Azidothymidine

Cat.No: TNU1111

Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83833

Synonym: Rp-dUTP-α-S

2’,3’-Bis(O-t-butyldimethylsilyl)-4’,5’-Didehydro-5’-deoxyuridine

Cat.No: TNU1186

2’-O-Acetyl-3’-azido-5’-O-(p-Toluoyl))-3’-deoxyuridine

Cat.No: TNU0932

Cat.No: T2169

Synonym: NSC309132,4-Deoxyuridine

Target: DNA Methyltransferase, Autophagy

Cat.No: T16785

Synonym: IPdR

Target: Others

Cat.No: T1408

Synonym: Xeloda,卡培他滨,Capecitibine,Capiibine,RO 09-1978

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T24881

Synonym: NB 1011,NB-1011,NB1011

Idoxuridine hydrate

Cat.No: T61492

Biotin-16-dUTP trisodium

Cat.No: T75341

(E)-5-(2-Bromovinyl)uracil

Cat.No: T35439

Cat. No.	Product Name	Target	Signaling Pathways
T1721	2'-Deoxyuridine Uracil deoxyriboside,2-deoxyuridine,2'-dU,2'-脱氧尿苷	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	2'-Deoxyuridine (2-deoxyuridine) 可以促使染色体断裂，从而抑制 thymidylate 的合成活性，它也是合成 Edoxudine 的前体。
T38427	dUTP trisodium 2'-Deoxyuridine-5'-triphosphate trisodium salt,Deoxyuridine triphosphate	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	dUTP trisodium (Deoxyuridine triphosphate) 是在 5'-位具有三磷酸基团的脱氧尿苷磷酸盐，可用于 PCR。
T4735	2'-Deoxyuridine 5'-monophosphate disodium 2'-脱氧尿苷-5'-单磷酸二钠,2'-dUMP⋅2Na,2-脱氧尿嘧啶核苷-5'-单磷酸二钠盐,2'-Deoxyuridine 5'-monophosphate disodium salt	Others; Endogenous Metabolite	Metabolism; Others
	2'-Deoxyuridine 5'-monophosphate disodium (2'-dUMP⋅2Na) salt 能够被双底物酶胸苷酸合酶(TS) 还原甲基化为 dTMP (2'-deoxythymidine 5'-monophosphate)。其中 dTMP 是 DNA 合成所需的核苷酸。

天然产物

2'-Deoxyuridine

Cat.No: T1721

Synonym: Uracil deoxyriboside,2-deoxyuridine,2'-dU,2'-脱氧尿苷

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T38427

Synonym: 2'-Deoxyuridine-5'-triphosphate trisodium salt,Deoxyuridine triphosphate

Target: DNA/RNA Synthesis

2'-Deoxyuridine 5'-monophosphate disodium

Cat.No: T4735

Synonym: 2'-脱氧尿苷-5'-单磷酸二钠,2'-dUMP⋅2Na,2-脱氧尿嘧啶核苷-5'-单磷酸二钠盐,2'-Deoxyuridine 5'-monophosphate disodium salt

Target: Others, Endogenous Metabolite

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