首页工具

登录

搜索结果

Search Results for " αvβ3 "

36

抑制剂 & 化合物

3

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
TP1474	LXW7	Integrin	Cytoskeletal Signaling
	LXW7 是一种整合素αvβ3抑制剂，是含 Arg-Gly-Asp (RGD) 的环状肽，对αvβ3整联蛋白具有很高的结合亲和力，IC50为 0.68 μM。它可增强 VEGFR-2 磷酸化和 ERK1/2 活化，具有抗炎活性。
T6812L	Cyclo(-RGDfK) TFA	Integrin	Cytoskeletal Signaling
	Cyclo(-RGDfK) TFA 是一种选择性整合素αvβ3的有效抑制剂，其IC50值为 0.94 nM。它通过与细胞表面的 αvβ3 整合素结合，特异性靶向肿瘤微血管和癌细胞。
T6812	Cyclo(-RGDfK) Cyclo (-RGDfK)	Integrin	Cytoskeletal Signaling
	Cyclo(-RGDfK) (Cyclo (-RGDfK)) 是一种选择性整合素αvβ3的有效抑制剂，IC50值为 0.94 nM。它通过与细胞表面的 αvβ3 整合素结合，特异性靶向肿瘤微血管和癌细胞。
T83034	Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6)
	Anti-Mouse TCR V gamma 2 Antibody是一种针对小鼠TCR V gamma 2的IgG类型的抗体抑制剂，其宿主为Armenian Hamster。
TP1879L1	P11 acetate	Integrin	Cytoskeletal Signaling
	P11 acetate 是一种整合素 αvβ3-玻连蛋白相互作用拮抗剂 (IC50 = 2.74 nM)。
T6813	Cyclo(RGDyK) trifluoroacetate Cyclo(RGDyK)	Integrin	Cytoskeletal Signaling
	Cyclo(RGDyK) trifluoroacetate 是一种选择性αVβ3整联蛋白抑制剂，IC50为 20 nM。
T2494	Cilengitide 西仑吉肽,EMD 121974	Integrin; Autophagy	Autophagy; Cytoskeletal Signaling
	Cilengitide (EMD 121974) 是一种有效的 αvβ3/5 受体整合素抑制剂，可抑制 ανβ3和 ανβ5与玻连蛋白结合，IC50值分别为 4 和 79 nM。
T6657	SB273005	Integrin	Cytoskeletal Signaling
	SB273005 是一种有效的整合素抑制剂，对 αvβ3 受体和 αvβ5 受体的 Ki 分别为 1.2 nM 和 0.3 nM。
TQ0250	CWHM-12	Integrin	Cytoskeletal Signaling
	CWHM-12 是 αV 整合素的有效抑制剂，抑制αvβ8、αvβ3、αvβ6和αvβ1，IC50 为 0.2、0.8、1.5 和 1.8 nM。
T16085	MK-0429 L-000845704	Others	Others
	MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).
TP2148	LXW7 TFA (1313004-77-1 free base) LXW7 TFA	Integrin	Cytoskeletal Signaling
	LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3 integrin (IC50: 0.68 μM). It increases the phosphorylation of VEGFR-2 and activation of ERK1/2.
T6806	Cilengitide TFA	Integrin; Autophagy	Autophagy; Cytoskeletal Signaling
	Cilengitide TFA 是一种选择性的 αvβ3和 αvβ5受体整合素抑制剂，IC50分别为 4 nM 和 79 nM。对 GP IIb/IIIa 的选择性约为 10 倍。
TP1459L	Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)	Integrin	Cytoskeletal Signaling
	Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base) 是一种源自纤连蛋白的细胞结合区域的细胞结合蛋白结构域。
TP1879	HSDVHK-NH2 P11
	Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
T16851	SB-267268	Others	Others
	SB-267268 inhibits human and mouse αvβ3 (IC50s: 0.68 and 0.29 nM, respectively). SB-267268 is a selective and nonpeptidic alpha(v)beta3 and alpha(v)beta5 integrins antagonist (Kis: 0.9, 0.5 and 0.7 nM for human αvβ3, monkey αvβ3 and human αvβ5, respective
TP2390	Maraciclatide NC-100692,NC 100692,NC100692
	Maraciclatide is a radiopharmaceutical targeting αvβ3 integrin.
T11663	Integrin-IN-2	Others	Others
	Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively.
T8726	Cyclo(RGDyK)	Integrin	Cytoskeletal Signaling
	Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
T15584	Integrin Antagonists 27	Others	Others
	Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.
T69460	TSRI265
	TSRI265 is a novel αvβ3 ligand, disrupting the integrin-MMP2 interaction and showing antiangiogenic activit, inhibiting angiogenesis and tumor growth in vivo.
T82516	E(c(RGDfK))₂
	E(c(RGDfK))是一种针对αvβ3整联蛋白的特异性结合片段，表现出对肿瘤的靶向作用。在人卵巢癌OVCAR-3异种移植肿瘤模型中，该化合物的摄取有所提升，适用于癌症研究领域。
T68462	D-Ornithine lactam
	D-Ornithine lactam is a building block. It has been used in the synthesis of hepatitis C virus non-structural protein 5B inhibitors, as well as αVβ3 integrin receptor antagonists.
T75990	Cyclo(Arg-Gly-Asp-D-Phe-Val)
	Cyclo(Arg-Gly-Asp-D-Phe-Val) 为一种整合素αvβ3抑制剂，具有抗肿瘤活性，并可用于急性髓系白血病的研究。
T76068	Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA
	Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA 是一种环状RGD多肽，对αvβ3有高亲和性，能干扰细胞整合素之间的相互作用。此化合物能抑制胚胎干细胞(ESC)的多潜能性基因表达，并可在体内减少mESC的致瘤潜力，因此适用于肿瘤研究领域。
T76807	Etaracizumab
	Etaracizumab (LM 609)，一种αvβ3整合素IgG1单克隆抗体，具有抑制血管生成和黑色素瘤生长的作用，可用于抗癌研究。
T75835	HSDVHK-NH2 TFA
	HSDVHK-NH2 TFA 作为一种整合素 αvβ3-玻璃体结合蛋白的互作拮抗剂，其IC50值达到1.74 pg/mL (2.414 pM)。
T10920	Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA	Others	Others
	Arg-Gly-Asp-D-Phe-Val (TFA) has anti-tumor activity and is an inhibitor of integrin αvβ3.
T75724	LXW7 TFA
	LXW7 TFA, 包含 Arg-Gly-Asp (RGD) 的环状肽，作为整合素αvβ3抑制剂，展示出对αvβ3整联蛋白高度的结合亲和力，其IC50值为0.68 μM。此外，LXW7 TFA 能够促进 VEGFR-2 磷酸化和 ERK1/2 激活，显示出抗炎活性。
T74400	TC113
	TC113是一种与c(RGDyK)偶联的Gemcitabine。它通过整合素αvβ3可被A549细胞内化。此外，TC113对WM266.4和A549细胞表现出显著的抗增殖效果。
TP1974	Obtustatin
	Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitum
T78064	Synstatin (92-119) SSTN92-119	Integrin	Cytoskeletal Signaling
	Synstatin (92-119)为一种抗肿瘤化合物，它能够抑制血管生成与癌细胞侵袭，通过下调整合素αvβ3，降低VEGF与FGF-2的活化。
T83736	RTDLDSLRTYTL TFA
	RTDLDSLRTYTL是一种αVβ6整合素配体。它选择性地抑制纤维连接蛋白与αVβ6整合素的结合，相比之下，对于纤维连接蛋白与αVβ3或αVβ5以及纤维蛋白原与αIIβ3的结合则几乎不产生影响（IC50分别为0.02, >50, >50, 和 >50 µM）。此外，RTDLDSLRTYTL还能以浓度依赖的方式抑制HT-29结肠癌细胞与纤维连接蛋白的结合。
T75761	Gly-Arg-Gly-Asp-Ser TFA GRGDS TFA
	Gly-Arg-Gly-Asp-Ser (TFA) 是一种与糖蛋白和骨桥蛋白在细胞结合域中起作用的五肽。该化合物能够与整合素整联蛋白受体αvβ3和αvβ5结合，其IC50值分别约为5 μM和6.5 μM。
TP2098	Echistatin Echistatin, α1 isoform
	Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3)
T70368	SF0166
	SF0166 是一种有效的选择性 αvβ3拮抗剂，对于 αvβ3，αvβ6，和 αvβ8的IC50值分别为 0.6 nM, 8 nM 和 13 nM。SF0166 抑制人、大鼠、兔和狗细胞系中玻连蛋白的细胞粘附，IC50值为 7.6 pM 至 76 nM。SF0166 在氧诱导视网膜病变小鼠模型中减少新生血管。
TP1343	RGD Trifluoroacetate
	RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.RGD Trifluoroacetate is the most effective and most often employed pept

化合物

Cat.No: TP1474

Target: Integrin

Cyclo(-RGDfK) TFA

Cat.No: T6812L

Target: Integrin

Cat.No: T6812

Synonym: Cyclo (-RGDfK)

Target: Integrin

Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6)

Cat.No: T83034

Cat.No: TP1879L1

Target: Integrin

Cyclo(RGDyK) trifluoroacetate

Cat.No: T6813

Synonym: Cyclo(RGDyK)

Target: Integrin

Cat.No: T2494

Synonym: 西仑吉肽,EMD 121974

Target: Integrin, Autophagy

Cat.No: T6657

Target: Integrin

Cat.No: TQ0250

Target: Integrin

Cat.No: T16085

Synonym: L-000845704

Target: Others

LXW7 TFA (1313004-77-1 free base)

Cat.No: TP2148

Synonym: LXW7 TFA

Target: Integrin

Cilengitide TFA

Cat.No: T6806

Target: Integrin, Autophagy

Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)

Cat.No: TP1459L

Target: Integrin

Cat.No: TP1879

Synonym: P11

Cat.No: T16851

Target: Others

Cat.No: TP2390

Synonym: NC-100692,NC 100692,NC100692

Cat.No: T11663

Target: Others

Cat.No: T8726

Target: Integrin

Integrin Antagonists 27

Cat.No: T15584

Target: Others

Cat.No: T69460

Cat.No: T82516

D-Ornithine lactam

Cat.No: T68462

Cyclo(Arg-Gly-Asp-D-Phe-Val)

Cat.No: T75990

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA

Cat.No: T76068

Cat.No: T76807

Cat.No: T75835

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA

Cat.No: T10920

Target: Others

Cat.No: T75724

Cat.No: T74400

Cat.No: TP1974

Synstatin (92-119)

Cat.No: T78064

Synonym: SSTN92-119

Target: Integrin

RTDLDSLRTYTL TFA

Cat.No: T83736

Gly-Arg-Gly-Asp-Ser TFA

Cat.No: T75761

Synonym: GRGDS TFA

Cat.No: TP2098

Synonym: Echistatin, α1 isoform

Cat.No: T70368

RGD Trifluoroacetate

Cat.No: TP1343

Cat. No.	Product Name	Target	Signaling Pathways
T36715	Tetrac Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tetrac (Tetraiodothyroacetic acid)是L-甲状腺素(T4)的衍生物，是一种甲状腺整合素受体拮抗剂。Tetrac通过阻断EGFR介导的结直肠癌细胞信号传导来诱导抗增殖。Tetrac 可阻断 T4 和 3,5,3'-triiodo-L-thyronine (T3)在细胞表面甲状腺素整合素 αvβ3 受体上的作用。Tetra 具有抗血管生成、抗肿瘤活性和促凋亡活性。
TN5221	(-)-Variabilin
	Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro a...
T36295	Echistatin TFA
	Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ...

天然产物

Cat.No: T36715

Synonym: Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid

Target: Apoptosis, EGFR

Cat.No: TN5221

Cat.No: T36295

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼