Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WNK-IN-11 (Allosteric WNK Kinase Inhibitor) 是(WNK)激酶的变构抑制剂,能够抑制 WNK1 (IC50:4 nM) 。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 762 | 现货 | ||
5 mg | ¥ 1,830 | 现货 | ||
10 mg | ¥ 3,130 | 现货 | ||
25 mg | ¥ 5,170 | 现货 | ||
50 mg | ¥ 7,320 | 现货 | ||
100 mg | ¥ 9,870 | 现货 | ||
500 mg | ¥ 19,700 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,930 | 现货 |
产品描述 | WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM) |
靶点活性 | WNK1:4 nM |
体外活性 | WNK-IN-11 (compound 11) shows IC50<2 μM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility, albeit with still rather high microsomal clearance. WNK-IN-11 shows ATP noncompetitive inhibition. When tested against a panel of 440 human kinases at 10 μM concentration, 2500-fold above enzyme IC50 value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket. |
别名 | Allosteric WNK Kinase Inhibitor |
分子量 | 462.4 |
分子式 | C21H21Cl2N5OS |
CAS No. | 2123489-30-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 150 mg/mL (324.39 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1626 mL | 10.8131 mL | 21.6263 mL | 54.0657 mL |
5 mM | 0.4325 mL | 2.1626 mL | 4.3253 mL | 10.8131 mL | |
10 mM | 0.2163 mL | 1.0813 mL | 2.1626 mL | 5.4066 mL | |
20 mM | 0.1081 mL | 0.5407 mL | 1.0813 mL | 2.7033 mL | |
50 mM | 0.0433 mL | 0.2163 mL | 0.4325 mL | 1.0813 mL | |
100 mM | 0.0216 mL | 0.1081 mL | 0.2163 mL | 0.5407 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
WNK-IN-11 2123489-30-3 Cell Cycle/Checkpoint Metabolism Serine/threonin kinase Threonine proteases inhibit WNKIN11 Serine proteases Serine endopeptidases Inhibitor Allosteric WNK Kinase Inhibitor Ser/Thr Protease WNK IN 11 inhibitor