Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LDN-212320 (OSU-0212320) 是兴奋性氨基酸转运体 2(EAAT2)/谷氨酸转运体(GLT-1)的激活剂。它通过上调海马和 ACC 星形胶质细胞 GLT-1 的水平来预防伤害性疼痛。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 248 | 现货 | ||
2 mg | ¥ 355 | 现货 | ||
5 mg | ¥ 578 | 现货 | ||
10 mg | ¥ 847 | 现货 | ||
25 mg | ¥ 1,590 | 现货 | ||
50 mg | ¥ 3,160 | 现货 | ||
100 mg | ¥ 4,650 | 现货 | ||
500 mg | ¥ 9,870 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 638 | 现货 |
产品描述 | LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h. |
体外活性 | LDN/OSU-0212320 enhanced EAAT2 protein levels and glutamate uptake function but did not affect EAAT1 or EAAT3 protein levels and it also increased EAAT2 protein levels in a dose-dependent (EC50: 1.83 ± 0.27 μM) and time-dependent manner. LDN/OSU-0212320 treatment markedly prevented neuronal loss and degeneration, as assessed by MAP2 immunostaining [2]. |
体内活性 | After LDN/OSU-0212320(a single i.p.; 40-mg/kg) treatment, EAAT2 protein levels and associated glutamate uptake increased by approximately 1.5- to 2-fold at 2 hours and by approximately 2- to 3-fold between 8 and 24 hours after injection. Even 72 hours after injection, an approximately 1.5-fold increase in EAAT2 protein levels could still be detected (data not shown). LDN/OSU-0212320–induced EAAT2 protein levels and glutamate uptake was dose-dependent [2]. |
别名 | LDN-0212320, LDN/OSU-0212320, OSU-0212320 |
分子量 | 293.39 |
分子式 | C17H15N3S |
CAS No. | 894002-50-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (56.81 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4084 mL | 17.0422 mL | 34.0843 mL | 85.2108 mL |
5 mM | 0.6817 mL | 3.4084 mL | 6.8169 mL | 17.0422 mL | |
10 mM | 0.3408 mL | 1.7042 mL | 3.4084 mL | 8.5211 mL | |
20 mM | 0.1704 mL | 0.8521 mL | 1.7042 mL | 4.2605 mL | |
50 mM | 0.0682 mL | 0.3408 mL | 0.6817 mL | 1.7042 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LDN-212320 894002-50-7 Metabolism transporter Glutamate transporter 1 inhibit EAAT2 LDN/OSU 0212320 LDN/OSU0212320 LDN 0212320 Inhibitor LDN-0212320 LDN 212320 OSU 0212320 OSU0212320 LDN0212320 GLT-1 Excitatory amino acid transporter 2 LDN212320 LDN/OSU-0212320 OSU-0212320 inhibitor