Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cysteamine hydrochloride (Thioethanolamine Hydrochloride) 是一种可口服的,用于肾病型胱胺酸症的小分子药物,也可作为抗氧化剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 333 | 现货 | ||
5 g | ¥ 418 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 418 | 现货 |
产品描述 | Cysteamine hydrochloride (Thioethanolamine Hydrochloride) is an agent for the treatment of nephropathic cystinosis and an antioxidant. |
体外活性 | Cysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with Water2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death. [1] Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes. [2] |
体内活性 | Cysteamine is introduced as a treatment for cystinosis by depleting lysosomal cystine. Cystamine can inhibit transglutaminase activity by binding to the cysteine in its active center. Cysteamine increases brain levels of brain-derived neurotrophic factor (BDNF), which is caused by the increased expression of the heat shock DNAJ-containing protein 1 (HSJ1). Cysteamine inhibits the formation of gastric and mammary tumors that are induced chemically or after irradiation, respectively. The administration of Cysteamine is also able to inhibit the metastasis of pancreatic cancer in a mouse model by decreasing the expression and activity of metalloproteinases. [1] |
别名 | 2-Mercaptoethylamine Hydrochloride, β-Mercaptoethylamine Hydrochloride, 半胱胺盐酸盐, Thioethanolamine Hydrochloride, 2-Aminoethanethiol Hydrochloride, Cysteamine HCl, Bekaptan |
分子量 | 113.61 |
分子式 | C2H7NS·HCl |
CAS No. | 156-57-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 22 mg/mL (193.6 mM)
H2O: 21 mg/mL (184.8 mM)
DMSO: 22 mg/mL (193.6 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / H2O / DMSO | 1 mM | 8.802 mL | 44.0102 mL | 88.0204 mL | 220.0511 mL |
5 mM | 1.7604 mL | 8.802 mL | 17.6041 mL | 44.0102 mL | |
10 mM | 0.8802 mL | 4.401 mL | 8.802 mL | 22.0051 mL | |
20 mM | 0.4401 mL | 2.2005 mL | 4.401 mL | 11.0026 mL | |
50 mM | 0.176 mL | 0.8802 mL | 1.7604 mL | 4.401 mL | |
100 mM | 0.088 mL | 0.4401 mL | 0.8802 mL | 2.2005 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cysteamine hydrochloride 156-57-0 Apoptosis Autophagy Immunology/Inflammation Metabolism NF-Κb Others Reactive Oxygen Species Endogenous Metabolite cystinosis b-Mercaptoethylamine Hydrochloride antioxidant 2-Aminoethanethiol nephropathic 2-Mercaptoethylamine Hydrochloride Inhibitor Cysteamine β-Mercaptoethylamine Hydrochloride 半胱胺盐酸盐 Thioethanolamine Hydrochloride 2-Aminoethanethiol Hydrochloride inhibit Cysteamine Hydrochloride beta-Mercaptoethylamine Hydrochloride orally 2-Mercaptoethylamine Cysteamine HCl Bekaptan inhibitor