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Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.

Cat. No.	Product Name	CAS No.	Purity
T1444	Lomefloxacin 洛美沙星	98079-51-7	98%
T1444	Lomefloxacin (SC47111A) 是一种广谱喹诺酮类抗生素，具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。
T5820	Amsacrine hydrochloride 盐酸胺苯吖啶	54301-15-4	98%
T5820	Amsacrine hydrochloride (acridinyl anisidide hydrochloride) 是一种拓扑异构酶 II 抑制剂，用于治疗急性髓细胞性白血病。
T1123	Camptothecin 喜树碱	7689-03-4	98%
T1123	Camptothecin (CPT) 属于生物碱类天然产物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂 (IC50=679 nM)，具有特异性。Camptothecin 具有抗肿瘤活性，可以诱导细胞凋亡。
TQ0134	Podocarpusflavone A 竹柏双黄酮 A	22136-74-9	98%
TQ0134	Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
T6467	Cardioxane 右雷佐生盐酸盐	149003-01-0	98%
T6467	Cardioxane (ADR-529) 是一种心脏保护剂。