Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.

Cat. No.	Product Name	CAS No.	Purity
T82935	AuM1Gly 化合物 AuM1Gly		98%
T82935	AuM1Gly 是拓扑异构酶 I (topoisomerase I) 的抑制剂，对 MDA-MB-231 乳腺癌细胞的增殖产生影响，表现出低纳摩尔范围的 IC50 值。
TQ0049	MC-DOXHZN hydrochloride MC-DOXHZN盐酸盐	480998-12-7	98%
TQ0049	MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
TN4172	Guajadial B 化合物 TN4172	1414455-03-0	98%
TN4172	Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines,...
T15200	Edotecarin 化合物 T15200	174402-32-5	98%
T15200	Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
TN2464	Eleutherin 红葱醌	478-36-4	98%
TN2464	Eleutherin is a natural product from Eleutherine americana
TN4173	Guajadial C 化合物 TN4173	1529775-02-7	98%
TN4173	Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
TN1889	Lupalbigenin 化合物Lupalbigenin	76754-24-0	98%
TN1889	Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN5190	Tryprostatin A 化合物 TN5190	171864-80-5	98%
TN5190	Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
T72153	Topoisomerase IV inhibitor 1 化合物 Topoisomerase IV inhibitor 1	2883403-42-5	98%
T72153	TopoisomeraseIV inhibitor 2 (compound 7d) 作为DNA拓扑异构酶IV（TOPO IV）抑制剂，展现出高效的活性，其对TOPO IV的IC50值为0.23 μM，而对DNA促旋酶的IC50为0.43 μM。此外，该化合物在抗菌领域同样表现出较强的能力，对金黄色葡萄球菌Nerman菌株...
T72154	Topoisomerase IV inhibitor 2 化合物 Topoisomerase IV inhibitor 2	2883403-36-7	98%
T72154	TopoisomeraseIV inhibitor 2 (compound 5d) 是一种 DNA 拓扑异构酶 IV 抑制剂，其对 TOPO IV 和 DNA 促旋酶的 IC50 值分别为 0.35 μM 和 0.55 μM。此化合物显示出针对 Staphylococcus aureus Newman 菌株和 Esche...
T73421	CPT-Se3 化合物 CPT-Se3	2968315-02-6	98%
T73421	CPT-Se3为含硒的喜树碱前体活性分子，其杀癌和抗肿瘤效力显著。它通过降低GSH/GSSG比率及总硫醇水平，增加Hep G2细胞中ROS含量，触发癌细胞凋亡。CPT-Se3对HeLa、Hep G2、A549及SMMC-7721细胞线具备显着细胞毒性，IC50值介于2.19-4.7 μM。
T73422	CPT-Se4 化合物 CPT-Se4	2968315-03-7	98%
T73422	CPT-Se4为含硒前体活性分子的喜树碱(CPT)衍生物，对癌细胞具有较高杀伤力和抑制肿瘤生长效果。在降低GSH/GSSG比率和总硫醇的同时，CPT-Se4能够增加Hep G2细胞中的ROS水平，触发癌细胞凋亡。此化合物对HeLa、Hep G2、A549和SMMC-7721细胞系显示出显著的细胞毒性，IC50值范围为2....
T74364	SDOX 化合物 SDOX	2921601-78-5	98%
T74364	SDOX为Doxorubicin的前体药物，通过脂质体递送至肿瘤细胞内，在GSH过量释放条件下，触发DOX释放。该机制在不损害抗癌效果的同时，极大地降低了对正常组织的毒副作用。
TN1734	Heveaflavone 橡胶树双黄酮	23132-13-0	98%
TN1734	Heveaflavone 抑制拓扑异构酶 I 并清除 DPPH 自由基，具有抗增殖和抗氧化作用。
T14703	Karenitecin 化合物 T14703	203923-89-1	98%
T14703	Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
T14953	Chloroquinoxaline sulfonamide 化合物 T14953	97919-22-7	98%
T14953	Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
T15054	Daun02 化合物 T15054	290304-24-4	98%
T15054	Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
T1456	Doxorubicin 阿霉素	23214-92-8	98%
T1456	Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素，具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II，IC50分别为0.8 μM 和2.67 μM，从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬。
TN5133	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone 化合物 TN5133	125537-92-0	98%
TN5133	5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
TN2953	3-Hydroxysarpagine 化合物 TN2953	857297-90-6	98%
TN2953	3-Hydroxysarpagine是一种天然产物，属于夹竹桃科萝芙木属，其产品编号为 TN2953，CAS号为 857297-90-6。3-Hydroxysarpagine可用作对照参考。