17
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4502 |
BISMUTH SUBGALLATE
次没食子酸铋,Dermatol Puder,Bismuth Gallate |
Others | Others |
Bismuth subgallate (Dermatol Puder) 是一种止血剂,可作用于凝血因子 XII ,促使凝血级联的激活,改善纤维蛋白凝块的早期形成。 | |||
T35343 |
MTI-31
MTI-31,LXI-15029 |
mTOR | PI3K/Akt/mTOR signaling |
MTI-31 (LXI-15029) 是口服有效的,高度选择性的mTORC1和mTORC2抑制剂,对 mTOR 的Kd 为 0.20 nM,IC50为 39 nM。MTI-31可用于乳腺癌的研究。 | |||
T77372 |
Tisotumab
1E10,1.00E+10 |
Others | Others |
Tisotumab (Anti-Human F3 Recombinant Antibody) 是一种针对组织因子 (TF) 的人 IgG1 单克隆抗体。Tisotumab 参与抗体偶联药物,可用于研究癌症。 | |||
T76761 |
Olaratumab
LY3012207,IMC-3G3 |
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Olaratumab(IMC-3G3) 是一种人源抗血小板衍生生长因子受体α (PDGFRα)单克隆 IgG1 抗体,具有抗肿瘤作用,可用于研究晚期软组织肉瘤。 | |||
T15577 |
Indobufen
Ibustrin,吲哚布芬 |
COX | Immunology/Inflammation; Neuroscience |
Indobufen (Ibustrin) 是一种血小板聚集抑制剂,是下调单核细胞中的组织因子,可逆抑制血小板环氧合酶 (Cox) 的活性和血栓素 A2 (TxA2) 的合成。 | |||
T21632 |
Myoseverin
|
Others; Microtubule Associated | Cytoskeletal Signaling; Others |
Myoseverina 是多核肌管可逆分裂成单核片段的诱导剂,影响多种生长因子、免疫调节、细胞外基质重塑和应激反应基因的表达,与伤口愈合和组织再生相关通路的激活一致。 | |||
T3469 |
PCI-27483
PCI27483 |
Others | Others |
PCI-27483 是一种FVIIa/tissue factor 抑制剂,具有抗肿瘤的作用。 | |||
T28222 |
5-Hydroxy-1-methylhydantoin
HD-003,HD003,5-羟基-1-甲基咪唑啉-2,4-二酮,NZ419,NZ-419,HD 003,NZ 419 |
Bradykinin Receptor | GPCR/G Protein |
5-Hydroxy-1-methylhydantoin (HD-003) 是一种可能用于治疗肾衰竭的抗氧化剂。它是肌酐代谢物,是一种羟基自由基清除剂,此前已显示通过抑制大鼠慢性肾病的进展来提供肾脏保护。 它是一种新型抗氧化药物,可完全抑制 B2-激肽受体(B2KR) 对 VSMC 中高葡萄糖 (25 mM) 刺激的反应,并且还显示可减弱 BK 对 VSMC 重塑的影响。它抑制 BK 诱导的 MAPK 磷酸化增加并减弱 VSMC 中结缔组织生长因子 (CTGF) 蛋白水平的增加。这些研究结果表明,它可能通过其抗氧化特性赋予血管保护免受高葡萄糖浓度和 BK 刺激以改善血管损伤和重塑。 | |||
T29501 |
A 68828
A68828,A-68828 |
||
A 68828 is an analog of the atrial natrium factor. It improves kidney function and reduces tissue damage. | |||
T69456 | Melagatran monohydrate | ||
Melagatran monohydrate is a thrombin inhibitor. Melagatran prevents tissue factor expression in human platelet-monocyte heterotypic complexes. Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in apolipoprotein E-deficient mice. | |||
T81854 |
Marstacimab
PF-06741086 |
||
Marstacimab (PF-06741086),一种针对组织因子通路抑制剂(TFPI)的单克隆抗体,适用于血友病研究。 | |||
T76921 | Befovacimab | ||
Befovacimab (BAY 1093884),一种全人源单克隆IgG2抗体,特异性结合于组织因子通路抑制剂(TFPI),适用于血友病A/B的研究。 | |||
T77881 |
Tisotumab vedotin
|
||
Tisotumab vedotin是一种针对组织因子(tissue factor, TF)的抗体-药物偶联物(ADC),由全人源单克隆抗体(TF-011)与Monomethyl Auristatin E (MMAE)耦合而成,具有显著抗肿瘤活性,适用于晚期或转移性实体瘤的治疗研究。 | |||
T75152 | ARC19499 | ||
ARC19499 是一种核酸适配体, 与组织因子通路抑制剂(TFPI)特异性结合,阻断 TFPI 对factor Xa 和 TF/factor VIIa 复合物的抑制作用。ARC19499 纠正血友病A 和B 血浆中的凝血酶生成,并恢复凝血。 | |||
T76804 |
FG-3019
|
||
FG-3019 (Pamrevlumab)为重组人源化抗体,特异性结合于结缔组织生长因子(CTGF)。适用于特发性肺纤维化(IPF)研究领域。 | |||
T68302 |
KD3010 tosylate
|
||
KD-3010 is a peroxisome proliferator-activated receptor delta agonist potentially for the treatment of diabetes and obesity. KD-3010 dramatically ameliorates liver injury induced by carbon tetrachloride (CCl(4)) injections. Deposition of extracellular matrix proteins was lower in the KD3010-treated group than in the vehicle- or GW501516-treated group. Interestingly, profibrogenic connective tissue growth factor was induced significantly by GW501516, but not by KD-3010, following CCl(4) treatmen... | |||
T37651 |
5(S),6(R)-11-trans DiHETE
|
||
5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. 5(S),6(R)-11-trans DiHETE has been found in rat kidney homogenates and is potentially formed by the epoxide hydrolase pathway in this tissue. The isomerase activity responsible for the conversion of leukotriene B4 (LTB4) to 6-trans LTB4 in rat kidney homogenates has also been implicated in its formation. 5(S),6(R)-11-trans DiHETE... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2S0504 |
Ilexoside D
|
Others | Others |
Ilexoside D has ant-allergic, and anti-coagulant activities, it shows anti-tissue factor activity as well as the antithrombotic activity. | |||
T2S2264 |
Linalool
Linalol,(±)-Linalool,Phantol,沉香醇 |
Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA 受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 | |||
T41139 |
Echinocystic acid 28-O-β-D-glucoside
|
||
Echinocystic acid 28-O-β-D-glucoside is a metabolite resulting from the microbial oxidation and glucosidation of Echinocystic acid. It exhibits inhibitory activity towards the tissue factor pathway, with an IC50 value measured at 10.61 nM. |