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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T67805	Oxepinac
	oxepinac 是一种治疗疼痛性骨关节炎的有效且耐受性良好的化合物。oxepinac 在动物实验中对小鼠和家兔胎儿无致畸作用。
T41362	EM-12 Phthalimidinoglutarimide,2-(2,6-Dioxopiperidin-3-yl)phthalimidine	Others	Others
	2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12 (2-(2,6-Dioxopiperidin-3-yl)phthalimidine)) 是一种致畸 Thalidomide 类似物，比 Thalidomide 活性更高，水解更稳定。2-(2,6-Dioxopiperidin-3-yl)phthalimidine 增强 1,2-dimethylhydrazine 诱导大鼠结肠癌的作用。
T0213	Thalidomide Thalomid,沙利度胺,Sedoval	Apoptosis; TNF; Autophagy; Ligand for E3 Ligase; Molecular Glues	Apoptosis; Autophagy; PROTAC
	Thalidomide (Thalomid) 能够抑制 cereblon，即 cullin-4 E3 泛素连接酶复合物 CUL4-RBX1-DDB1 的一部分，Kd 值约为 250 nM，具有免疫调节、抗炎、抗肿瘤作用。它可以作为分子胶来增强底物。
T78522	SRI 6409-94	Others	Others
	SRI 6409-94为一种口服活性的Ro 13-6298类似物，具备致畸性。该化合物可作分子工具研究视黄醇三维构型与致畸作用间的关联。
T29979L	Amidantel free base BAYd 8815,BAY d8815,BAYd-8815,Amidantel,BAY d-8815,BAY d 8815
	Amidantel free base is a new aminophenylamidine with an interesting anthelminthic spectrum. In rodents the compound is active against nematodes, filariae and cestodes. Of special interest is the high efficacy in dogs against hookworms and large roundworms
T29979	Amidantel hydrochloride BAY-d 8815,BAY d 8815
	Amidantel hydrochloride is a new aminophenylamidine with an interesting anthelminthic spectrum. In rodents the compound is active against nematodes, filariae and cestodes. Of special interest is the high efficacy in dogs against hookworms and large roundw

化合物

Synonym: Phthalimidinoglutarimide,2-(2,6-Dioxopiperidin-3-yl)phthalimidine

Target: Others

Thalidomide

Cat.No: T0213

Synonym: Thalomid,沙利度胺,Sedoval

Target: Apoptosis, TNF, Autophagy, Ligand for E3 Ligase, Molecular Glues

Synonym: BAYd 8815,BAY d8815,BAYd-8815,Amidantel,BAY d-8815,BAY d 8815

Target:

Amidantel hydrochloride

Cat.No: T29979

Synonym: BAY-d 8815,BAY d 8815

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T19412	Macrozamin 甲基氧化偶氮甲醇樱草糖苷,大泽明素	Others	Others
	Macrozamin 是苏铁的一种主要成分，表现出致癌，致畸，诱变和神经毒性作用。
T3363	Jervine 蒜黎芦碱,Iervin,11-Ketocyclopamine,Jerwiny	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	Jervine (Jerwiny) 是一种有效的刺猬 (Hh) 抑制剂(IC50:500-700 nM)。它是一种天然致畸性甾体生物碱，来自于 Veratrumalbum 的根茎，具有抗炎和抗氧化作用。
T8100	Azetidine-2-carboxylic acid	Others	Others
	Azetidine-2-carboxylic acid 是脯氨酸的非蛋白原氨基酸同系物，可以在常见的甜菜中获得。在许多物种中，它能够错误地掺入蛋白质中代替脯氨酸，是一种致毒和致畸剂。
T39854	Cycloposine
	Cycloposine, a steroidal alkaloid present in the roots and rhizomes of Veratrum californicum, is known to possess teratogenic properties.
TN3409	Anagyrine	Antifection	Microbiology/Virology
	Anagyrine, is the responsible teratogen from teratogenic lupins, can produce congenital deformities in calves typical of crooked calf disease; it also can induce red cell aplasia, vascular anomaly, and skeletal dysplasia.(-)-Anagyrine and (-)--Methylcytisine have nematicidal activities against Pine Wood Nematodes.
TN4346	Jaconine	Others	Others
	Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.