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Search Results for " rectifier "

23

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22408	Proflavine 吡啶-3,6-二胺,3,6-Diaminoacridine	Antibacterial	Microbiology/Virology
	Proflavine (3,6-Diaminoacridine) 是吖啶染料，可用作抗菌剂。它是 DNA 嵌入剂，能够阻滞Kir3.2孔。它用作与 Kir3.2 相关的神经系统疾病的研究。
T0438	Proflavine Hemisulfate 3,6-Diaminoacridine hemisulfate,Proflavin hemisulfate,硫酸原黄素	Others; Potassium Channel; DNA; Thrombin; Antibacterial; Autophagy	Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Others; Proteases/Proteasome
	Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) 是一种 DNA 嵌入剂，也是一种吖啶染料。它是抗菌剂，也可作为 Kir3.2孔阻滞剂，可研究与 Kir3.2 相关的神经系统疾病。
T22745	DPO-1	Potassium Channel	Membrane transporter/Ion channel
	DPO-1 可以高效抑制电压门控钾离子通道Kv1.5，也可以阻断超快速延迟整流钾电流。它能够预防房性心律失常。
T5585	AM-92016 hydrochloride	Potassium Channel	Membrane transporter/Ion channel
	AM-92016 hydrochloride 是一种整流钾电流的特异性阻断剂。它能够延迟整流钾通道，使膜复极化，限制神经冲动的持续时间。
T27205	DPI 201-106 DPI-201-106	Sodium Channel	Membrane transporter/Ion channel
	DPI 201-106对电压门控钠通道的有心脏选择性调节活性，从而产生正性肌力作用。DPI 201-106 具有协同肌膜和细胞内作用机制。
T7505	Azimilide Dihydrochloride NE-10064 Dihydrochloride,盐酸阿齐利特	Potassium Channel	Membrane transporter/Ion channel
	Azimilide Dihydrochloride (NE-10064 Dihydrochloride) 是 I(Ks) 和 I(Kr) 抑制剂，具有抗心律失常活性。
T3574	Sematilide hydrochloride 司美利特,CK-1752A,CK-1752,Sematilide HCl	Potassium Channel	Membrane transporter/Ion channel
	Sematilide hydrochloride (CK-1752) 是一种选择性的 IKr 通道阻滞剂。Sematilide 以浓度依赖性抑制延迟整流钾通道 (K+current)，IC50为 25 μM。Sematilide 是一种 III 类抗心律不齐剂。
T6476	Dofetilide UK 68789,UK-68798,Tikosyn,多非利特	Potassium Channel	Membrane transporter/Ion channel
	Dofetilide (UK 68789) 是一种具有口服活性、有效的且特异性的IKr 阻滞剂，作为 III 类抗心律失常药物。Dofetilide 可用于心血管疾病研究。
T15555	IK1 inhibitor PA-6	Potassium Channel	Membrane transporter/Ion channel
	IK1 inhibitor PA-6 是一种喷他脒类似物，是选择性的 IK1(KIR2.x 离子通道携带向内整流电流) 抑制剂，对人和老鼠中 KIR2.x 电流的 IC50值为 12-15 nM。它可上调 KIR2.1 的蛋白表达，诱导细胞内 KIR2.1 的蛋白的积累。它在房颤和心律失常的研究中具有潜力。
T31011	Coralyne chloride	Topoisomerase	DNA Damage/DNA Repair
	Coralyne chloride 是一种具有强抗癌活性的原小檗碱。它可用于制备 Coralyne 衍生物，是一种基于荧光 DNA 的分子整流剂，通过位点特异性插入构建成 DNA 双链体。它可作为一种拓扑异构酶 I 毒性分子，诱导拓扑异构酶 I 介导 DNA 裂解。
T24948	VU625 VU007625,VU 625,VU 007625,VU-625,VU-007625
	VU625 is an effective inhibitor of Aedes aegypti inward rectifier potassium channels.
T22662	Chromanol 293B	Others	Others
	slow delayed rectifier K+ current (IKs) blocker
T70194	AM92016
	AM92016 is a specific blocker of the time dependent delayed rectifier potassium current. AM92016 does not show any β-adrenoceptor blocking activity.
T14189	Almokalant H 234/09	Potassium Channel	Membrane transporter/Ion channel
	Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker. And it inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.
T15460	Halofantrine hydrochloride WR-171669,SKF-102886	Others	Others
	Halofantrine hydrochloride is a blocker of delayed rectifier potassium current. Halofantrine hydrochloride also via the inhibition of the human-ether-a-go-go-related gene (HERG) channel and a potent antimalarial agent.
T5336L	Zacopride Racemic zacopride
	Zacopride is a selective agonist of inward rectifier potassium current (I K1) channel, inhibiting ventricular arrhythmias without affecting atrial arrhythmias.
T80510	Tertiapin-RQ	Potassium Channel	Membrane transporter/Ion channel
	Tertiapin-RQ为抗抑郁特性的内向整流K+通道阻滞剂肽。
T61685	Ibutilide
	Ibutilide (U70226E free base) is a potent antiarrhythmic compound that extends the action potential duration. It effectively blocks the rapidly activating delayed rectifier potassium current (I Kr ) in AT-1 cells [1].
T17240	VU041	Others	Others
	VU041 is an inhibitor of Anopheles gambiae and Aedes aegypti inward rectifier potassium 1 channels (IC50: 2.5 μM and 1.7 μM, respectively). VU041 inhibits appreciably is mammalian Kir2.1 (IC50: 12.7 μM) and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1.
TP2114	Tertiapin-Q
	A high affinity blocker for inward-rectifier K+ channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and
T36740	Guanosine 5’-diphosphate (sodium salt hydrate)
	Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR2B) linked to the inward-rectifier potassium channel 6.1 (Kir6.1) in HEK293T cells in a patch-clamp assay.3 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002) 2.Vetter, I.R., and Wittinghofer, A.The guanine nucleotide-binding switch in three dimensionsScience294(5545)...
T80426	Jingzhaotoxin-IX	Sodium Channel	Membrane transporter/Ion channel
	Jingzhaotoxin-IX是由35个氨基酸残基组成的C端酰胺化神经毒素。该化合物既抑制电压门控钠通道（包括河豚毒素抗性和河豚毒素敏感亚型）又抑制Kv2.1通道，但对延迟整流钾通道Kv1.1、1.2和1.3无效。
T83749	Tertiapin LQ TFA TPNLQ
	Tertiapin LQ是源自蜜蜂毒素肽tertiapin的肽衍生物，同时也是向内整流钾(Kir)通道的抑制剂。它能够抑制由G蛋白激活的向内整流钾通道1（GIRK1）和GIRK4（即Kir3.1和Kir3.4）组成的异源多聚钾通道，以及向内整流钾通道1（Kir1.1）。在活体内，tertiapin LQ抑制在雪貂中对条件刺激的Purkinje细胞暂停响应。

化合物

Cat.No: T22408

Synonym: 吡啶-3,6-二胺,3,6-Diaminoacridine

Target: Antibacterial

Proflavine Hemisulfate

Cat.No: T0438

Synonym: 3,6-Diaminoacridine hemisulfate,Proflavin hemisulfate,硫酸原黄素

Target: Others, Potassium Channel, DNA, Thrombin, Antibacterial, Autophagy

Cat.No: T22745

Target: Potassium Channel

AM-92016 hydrochloride

Cat.No: T5585

Target: Potassium Channel

Cat.No: T27205

Synonym: DPI-201-106

Target: Sodium Channel

Azimilide Dihydrochloride

Cat.No: T7505

Synonym: NE-10064 Dihydrochloride,盐酸阿齐利特

Target: Potassium Channel

Sematilide hydrochloride

Cat.No: T3574

Synonym: 司美利特,CK-1752A,CK-1752,Sematilide HCl

Target: Potassium Channel

Cat.No: T6476

Synonym: UK 68789,UK-68798,Tikosyn,多非利特

Target: Potassium Channel

IK1 inhibitor PA-6

Cat.No: T15555

Target: Potassium Channel

Coralyne chloride

Cat.No: T31011

Target: Topoisomerase

Cat.No: T24948

Synonym: VU007625,VU 625,VU 007625,VU-625,VU-007625

Cat.No: T22662

Target: Others

Cat.No: T70194

Cat.No: T14189

Synonym: H 234/09

Target: Potassium Channel

Halofantrine hydrochloride

Cat.No: T15460

Synonym: WR-171669,SKF-102886

Target: Others

Cat.No: T5336L

Synonym: Racemic zacopride

Cat.No: T80510

Target: Potassium Channel

Cat.No: T61685

Cat.No: T17240

Target: Others

Cat.No: TP2114

Guanosine 5’-diphosphate (sodium salt hydrate)

Cat.No: T36740

Jingzhaotoxin-IX

Cat.No: T80426

Target: Sodium Channel

Tertiapin LQ TFA

Cat.No: T83749

Synonym: TPNLQ

Cat. No.	Product Name	Target	Signaling Pathways
T8040	Cholesterol myristate 胆甾烯基豆蔻酸酯,Cholesteryl myristate,胆固醇肉豆蔻酸,Cholesteryl tetradecanoate	Others; Potassium Channel; GABA Receptor; Endogenous Metabolite; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	Cholesterol myristate (Cholesteryl myristate) 是粗吻海龙中的一种类固醇，可与多种离子通道结合，例如nAChR、GABAA 受体和内向整流钾离子通道。
T4A2458	Resibufogenin 酯蟾毒配基,Bufogenin,Recibufogenin,酯蟾毒配基，蟾力苏	Others	Others
	Resibufogenin (Bufogenin) 是华蟾素的成分之一，表现出抑制氧化应激及肿瘤再生的活性。
TN3636	Chlorahololide C	Potassium Channel	Membrane transporter/Ion channel
	Chlorahololide C is a potent and selective potassium channel blocker, it exerts potent and selective inhibition on the delayed rectifier (I(K)) K(+) current with the IC(50) value of 3.6 +/- 10.1 mu M.

天然产物

Cholesterol myristate

Cat.No: T8040

Synonym: 胆甾烯基豆蔻酸酯,Cholesteryl myristate,胆固醇肉豆蔻酸,Cholesteryl tetradecanoate

Target: Others, Potassium Channel, GABA Receptor, Endogenous Metabolite, AChR

Cat.No: T4A2458

Synonym: 酯蟾毒配基,Bufogenin,Recibufogenin,酯蟾毒配基，蟾力苏

Target: Others

Chlorahololide C

Cat.No: TN3636

Target: Potassium Channel

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